Cancer Genomics and Bioinformatics

I focused on Next Generation Sequencing technologies and identified genetic mutations affecting the immune system which may lead to the development of more than one colorectal tumour at the same time (synchronous colorectal cancers). I rebuilt the clonal evolution of 20 synchronous colorectal cancer from whole exome sequencing and genome wide SNP array data.Lecturer for Translational Bioinformatics Workshop 2015, King’s College London, UK. Class on identification of mutations from… Show more I focused on Next Generation Sequencing technologies and identified genetic mutations affecting the immune system which may lead to the development of more than one colorectal tumour at the same time (synchronous colorectal cancers). I rebuilt the clonal evolution of 20 synchronous colorectal cancer from whole exome sequencing and genome wide SNP array data.Lecturer for Translational Bioinformatics Workshop 2015, King’s College London, UK. Class on identification of mutations from next-generation sequencing data and analysis of clonal evolution. Show less

Bioinformatics and Evolutionary Genomics of Cancer.Lecturer for the European School of Molecular Medicine, University of Milan, IT of classes for graduate students: • Cancer Evolution 2013; • Programming (R, C++ and bash) 2012, 2013.

I focused on post-transcriptional regulatory networks and the analysis of RNA binding protein-mRNA interactions, and their role in neurodegenerative diseases. I developed RNAmotifs, a software that evaluates the sequence around differentially regulated alternative exons to identify multivalent RNA binding motifs that regulate mRNA splicing.

I developed a C++ class library to the purpose of making the implementation of sequence analysis algorithms easier and faster when genomic annotations and variations need to be considered.I developed machine learning models (i.e. support vector machines) to predict the effect of genomic alteration on pre-mRNA splicing.I worked on different research projects focusing on evolutionary genomics, the role of transposable elements in shaping the genome, and population… Show more I developed a C++ class library to the purpose of making the implementation of sequence analysis algorithms easier and faster when genomic annotations and variations need to be considered.I developed machine learning models (i.e. support vector machines) to predict the effect of genomic alteration on pre-mRNA splicing.I worked on different research projects focusing on evolutionary genomics, the role of transposable elements in shaping the genome, and population genetics.Lecturer of "Concept of Informatics" for the School of Medicine of University of Milan, IT. Classes for undergraduate students; 2007, 2008 and 2009.Web designer and developer of http://bioinformatics.emedea.it Show less

I focused on the analysis of RNA binding-protein and mRNA interactions. I analysed data from splice junction microarray and iCLIP next generation sequencing (iCLIP-Seq) experiments to determine the RNA targets and position dependent splicing regulation by TDP-43 in neurodegenerative diseases as frontotemporal lobar degeneration and amyotrophic lateral sclerosis.