-Direct manager of the Miltenyi Biotec UK Clinical team. -Responsible for a group of 3 Clinical Account Managers and key accounts across the UK.-Forecasting monthly to assess current budget progression and setup of budget for subsequent year.-Regular interaction with country manager to report budget progress and any activities to act on deficits and enhance growth areas of the business. -Inter-company relationship building with customers which span multiple countries, and networking with internal/external organisations to facilitate strategic business growth.-Leading strategic meetings to align the entire Miltenyi pipeline with customer processes and procedures at the earliest stage to ensure effective strategic growth over multiple years.-Monitoring group opportunities and leads to ensure these are all followed up and matured with relavant stakeholder involvement from multiple groups within the business. -Supporting team needs and requirements, whilst liaising with company HQ to identify business gaps and improvements at senior levels.-Primary representative for Miltenyi UK at the Bioindustry Association (BIA) CGT Advisory Committee & Network.-Working on business cases for development of product/service gaps to ensure customer demand and requirements are met.-Interaction at senior level to assess market direction with 3-5 year plans of business growth and future product needs for customers. -Lead for legal agreements (NDA/CDA) with customers directly from account managers.

-Management of the clinical reagents/consumables/instruments (CliniMACS Plus and Prodigy) product range for Miltenyi Biotec UK.-Examples of complete clinical workflows are that of:-Graft engineering (Stem cell transplantation and subsequent resolution of viral reactivation issues).-Regenerative medicine (Use of Mesenchymal Stem/Stromal cells for tissue regeneration as a consequence of disease.-Immuno-oncology (Latest CAR T, CAR NK, CAR g/d T-cell therapies with strong focus on viral/non-viral transduction.-Therapeutic apheresis using TheraSorb system for LDL/LP(a) and IgM/A/G treatment pre-post organ transplant.-Working alongside cell and gene therapy customers to provide innovative solutions for the next generation of immune therapies.-Close liaison with research product team for early-stage monitoring of those customers with translational research aims to reach clinical level.-Business development of customers from all levels of size, from those at the very beginning to those already established and looking to expand. -Considerations of automation, scalability, reproducibility, safety and cost savings amongst many others.-Development and maintenance of relationships with customers and key opinion leaders in academia, biotech, CROs/CMOs and pharmaceutical companies across the UK. -Company representative at government-sponsored Advanced Therapy Treatment Centres (ATTC) for both the Northern Alliance, Midlands and Wales, with involvement in iMATCH and the London Advanced Therapies Network.-Regulatory compliance support for customers;-Documentation, support of quality management systems (QMS) -Effective communication/representation of the company, presenting seminars, talks/discussions at conferences/congresses, round table and panel discussions.-Training organisation/development coaching for new clinical team members, offering support and advice for adaptation of new staff to their role.

-Leading customer projects from optimisation to screening stage.-Organisation of work in terms of deadlines, capacity and equipment availability.-Writing of customer reports for technical review.-Group presentations of new data, technical improvements and case studies.-Technical presentations, both face-to-face and electronically.-Validation of Luminex platform for customer work, using clinical mAb analysis as a case study.-Technical lead on validation of Flow cytometry GFP/dsRed analysis in CHO cell lines.-Technical lead on TNFa binding assay on the surface of CD4+ T cells using Flow cytometry.-Involved in MAPPs assay development for peptide presentation on the surface of antigen-presenting cells.-Tier 2 Spill response trained, whereby chemical spillages require respiration for safe containment.-Organisation of the entire cropreserved PBMC bank for use in research and customer projects.

-Basic Immunophenotyping of human whole blood/PBMC samples for specific markers related to studies. (Including NK-related cells (CD56) and more typical T-cell populations)-Specialised immunophenotyping of exhaustion markers (I.e. PD1) and non- T-cell related markers of ADV-expanded PBMCs (Such as B-Cells)-Functionality assays using whole blood and early activation marker CD69 on patient samples under positive/negative control with specific peptides for viral activation.-Analysis of patient samples on adoptive cellular therapy for ADV, CMV, and future EBV work.-Use of MACsQuant 10 analyser for 8-colour, 3-laser analysis.-Analysis of antigen-specific CD3 T-cell populations and various naive, central memory, and effector memory subsets (For CD4 and CD8 subsets of CD3)-Use of Streptamer technology for analysis of antigen-specific CD3 T-cell populations, along with use of HLA-patient specific antibodies for haploidentical donors to distinguish between patient and donor streptamer-positive cells.-Use of ELISpot for additional detection of IFNy secreted from stimulated PBMC against control antigens, whole proteins/peptide fragments and HLA-specific peptides for CMV and ADV.-Use of ICS assay to assess expansion of CD4 and CD8 T-cells ex-vivo, via detection of IFNy both before and after expansion from whole blood.-Optimisation of ELISpot IFNy assay for increased detection and sensitivity.-Validation of 2-colour FluoroSpot assay for comparison to ELISpot protocol (IFNy and Granzyme B/TNFa)-Operation, setup and advanced usage of AID iSpot ELISpot/FluoroSpot analyser.-Data analysis of the above techniques for reporting and organisation.-Support in SOP and controlled form writing/checking to GxP standard.-Monitoring and maintenance of temperature controlled equipment to GLP standard.-IQ/OQ of temperature controlled laboratory equipment to GLP standard.-Initial phase GMP training for entry, gowning and operation inside a Clean room environment.

-Support of assays to assess Immunogenicity of various molecules (Vaccines, peptides, mAbs, etc).-Assays designed to generate data on both wanted/unwanted Immunogenicity.-Preparation, testing, and QC of cryopreserved PBMC supply for related assay work.-Techniques of analysis such as Flow cytometry, ELISpot, including T-cell proliferation assays, cell population percentage (And count), cell viability (And recovery).-Maintaining PBMC bank for study-specific use, such as levels of donor vials, cell population percentages, optimal response to positive controls, etc.-Operation and maintenance of Guava EasyCyte 8HT and FACScanto II Flow cytometry systems and software.-Ligation of DNA to confirm presence of desired sequence on specific agar growth plates.-Amplification of DNA via Transformation into competent cells for growth in culture.-Purification of DNA for extraction.-Low endotoxin work, and reduction from end products..-Stable and transient Transfection work on various mammalian cell lines.-Purification of Transfected culture to obtain sequence-related product.-Molecular Biology techniques to include SDS-PAGE, SE-HPLC, Western blot, ELISA, and IEF (For protein analysis)-Other techniques to include cell culture, aseptic technique, cell line development

-Manufacturing bioconjugates of various different marketed dyes/fluorescent molecules.-Understanding of the patented Lightning-Link technology to provide a wide range of options for customer conjugation of antibodies, and other molecules.-Organisation of stock levels, peripherals, and components for the manufacture of these bioconjugates.-Dealing with stock shortfall of many different lines of product to ensure customer demand is met. -Ability to scale up certain items in accordance with large orders, or increasing stock demands.-Assembly of kits of entire range of products to a high standard, and maintaining stock levels to meet demand from customers.-Training of staff to manufacture stock items.-Updating/writing of old/new MBRs to ensure current procedure is up-to-date, accurate, and to a high standard.-Lead in automation of the manfucturing process of bioconjugates, in order to acheive scale-up for future progression.-Techniques to include freeze-drying, spectrophotometry, various chemical reactions, buffer/reagent preparation, ion-exchange chromatography, etc.-Direct customer support on Flow cytometry issues with bioconjugates.

-Clinical sample analysis via flow cytometry of phases I, II, and III of clinical trials.-All work carried out under strict GLP/GCP regulations and procedures.-Regular updates on changes in GXP regulations to ensure harmonisation.-Various training courses conducted on techniques such as Flow cytometry and ELISpot.-Laboratory duties, including maintenance of Flow cytometers, class II laboratory hoods, incubators, etc.-Many different types of assay worked on frequently, such as Jernes Haemolytic plaque-forming assay, Lung lavage, Immunophenotyping, Local lymph node, etc.-Many different techniques learned and applied, such as Aseptic technique, antibody titrations, etc.-Method development and validation on clinical studies to GLP/GCP.-Data analysis of mulitple studies, assisting report writing and generation.-Regular involvement in scientific judgement on Flow cytometry data generated by other team members.-Operation and maintenance of Beckman-Coulter FC500 and EPICS Flow Cytometers.