Matthew L. Email and Phone Number

Biologics Drug Product Development, AbbVie Bay Area • Formulation development for complex biologics (mAbs, ADCs, proteins, etc.)

• Formulation characterization for a novel thin-film dosage form used for buccal or sublingual administration of biologics (Ad5, AAV9).• Quantify residual moisture in a thin film platform using Karl Fischer volumetric titration.• Evaluate the impact of residual moisture, relative humidity (RH), on stability profile of biologics stored within the film matrix, including quantification of percent recovery of infectious virus particles (Ad5, AAV9).• Mammalian cell culture: H1 HeLa, HeLa RC32, HEK 293, K562

• Purification process development for broadly neutralizing antibodies against HIV.• Developed robust antibody purification processes to support Phase I clinical trials; from clone selection stage to tech transfer stage• Planned and performed purification techniques including column chromatography, tangential flow filtration, clarification, viral filtration.

• Investigated how surface stiffness affects cell morphology of Nucleus Pulposus cells isolated from intervertebral discs of rat.• Studied how changes in intervertebral discs can lead to disc degeneration and aging.• Lab Skills: Mammalian Cell Culture, Aseptic technique, Immunofluorescent Staining, Bright Field Microscopy

• Oversaw all weight/fitness areas. Provide general assistance to Weight/Fitness Staff and ensured the health and safety of patrons.• CPR certified and AED trained. • Completed annual supervisory and leadership training.

• Worked with vaccine candidates for respiratory syncytial virus (RSV) and pandemic influenza. • Part of the technical team responsible for development and optimization of RSV-F protein purification process, primarily Ion Exchange and Affinity Chromatography (used GE AKTA Avant 150, UNICORN 6.4) • Gained hands-on execution of development, scale-up, and optimization of purification processes to support cGMP manufacturing.• Learned strategies to optimize process to improve product yield, quality, and purity.• Worked independently to perform analytical assays, interpret data; collaborated with others such as upstream process and analytical development groups. • Prepared summary presentations to team and senior management.

• Studied the therapeutic effects of the cancer drug HPPH and the toxicity of Graphene Oxide. • Conducted in vitro studies on the photodynamic effects of HPPH and Graphene Oxide in glioblastoma cancer cells.• Prepared and presented research results at the FDA 2013 Research Poster Presentation.