Matthew Tyson Email and Phone Number
Basel, Baselstadt
Matthew Tyson's Location
Raleigh, North Carolina, United States, United States
Matthew Tyson's Contact Details
Matthew Tyson work email
- Valid
- Valid
- Valid
- Valid
Matthew Tyson personal email
n/a
About Matthew Tyson
Biopharmaceutical professional with a strong background in downstream process development; with experience from pre-clinical, Phase I/II development and commercial process redevelopment.
Matthew Tyson's Current Company Details
Novartis Gene Therapies
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Associate Director at Novartis Gene Therapies
Basel, Baselstadt
- Website:
- novartis.com
- Employees:
- 5
- Company phone:
- +41 61 324 11 11
- Company email:
- eric.althoff@novartis.com
Matthew Tyson Work Experience Details
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Associate Director, Drug Substance Product LeadsNovartis Gene Therapies May 2022 - PresentBasel, Baselstadt, Ch
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Senior ManagerNovartis Gene Therapies Jan 2021 - May 2022Basel, Baselstadt, Ch
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ManagerNovartis Gene Therapies May 2019 - Jan 2021Basel, Baselstadt, Ch
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Downstream LeadThe Duke Human Vaccine Institute Mar 2018 - May 2019Durham, North Carolina, Us -
Scientist -DownstreamThe Duke Human Vaccine Institute Apr 2016 - Mar 2018Durham, North Carolina, Us
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Scientific Associate IiGsk Mar 2015 - Apr 2016Brentford, Middlesex, GbDownstream technical lead for recombinant subunit vaccine candidate produced in CHO. Responsible for planning and execution of experimentation to support downstream development activities, providing downstream support to stakeholders (upstream, analytical, formulation), aligning with other functional leads and project manager to ensure project timelines are met, and ensuring QbD principals were implemented in purification development activities. Acted as TD-DS viral clearance SME, this included authoring a strategic QbD Best Practice document that guides the process of ensuring viral safety of vaccine products, with a focus on viral clearance. Also acted in a support role for RNA vaccine candidate downstream development scale up and consistency runs. -
Scientific Associate IiNovartis Vaccines And Diagnostics May 2013 - Mar 2015Basel, Baselstadt, ChAs a member of the TD-Drug Substance team, developed and optimized purification processes for multiple vaccine candidates produced in CHO and MDCK cell culture, including recombinant secreted protein and split-subunit vaccine. This includes capture and intermediate chromatography resin screening (IEX, HIC, mix-mode, affinity) and development. Worked extensively with UNICORN™ software and ÄKTA purification systems. Performed and optimized tangential flow and normal flow unit operations. Performed process scale up and characterization activities, as well as tech transfer support. Acted as viral clearance SME for downstream group, including executing viral spiking studies at CRO’s, validating viral clearance scaled down models, evaluation of novel viral clearance technologies, and ensuring viral clearance claims align with regulatory considerations. Performed basic analytical techniques: SDS-PAGE, Western Blot, total protein assays, and spectrophotometry; and evaluated RP-HPLC, SEC-HPLC, qPCR, ELISA to support key downstream decisions. Performed all scientific operations/documentation in GDP compliant format and presented on scientific findings to forums of various sizes. Coordinated efforts between development units to ensure that individual efforts aligned with project timelines and goals.
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Development Engineer INovartis Vaccines And Diagnostics Aug 2012 - May 2013Basel, Baselstadt, ChAs a member of the TD-Drug Substance team, developed and optimized purification processes for a recombinant glycoprotein vaccine candidate produced in CHO cells. Screened and characterized multiple resins for both capture and polishing column chromatography steps; these resins include cation exchange, anion exchange, hydrophobic interaction, and mix-mode interaction resins. Led optimization efforts for the column chromatography polishing step; with the following key attributes driving optimization: purity, step yield, process efficiency, and product stability. Worked extensively with UNICORN™ software and ÄKTA purification systems. Performed and optimized ultrafiltration/diafiltration unit operations and performed basic analytical techniques: SDS-PAGE, Western Blot, and spectrophotometry to evaluate key process parameters. Performed all scientific operations/documentation in GMP compliant format and presented on scientific findings to forums of various sizes. Coordinated efforts between development units to ensure that individual efforts aligned with project timelines and goals.
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Manufacturing Science & Technology InternPfizer May 2011 - Aug 2011New York, New York, UsWorked with the purification team to develop purification processes for a recombinant carrier protein produced in bacteria. The main focus was on characterization of the ion exchange column chromatography step and the impurity profile of the column eluate. Worked extensively with UNICORN™ software and the Akta Pilot/Explorer purification systems. Also performed the following unit operations: centrifugation, depth filtration, ultrafiltration, diafiltration, and sterile filtration. Presented scientific findings to internal group meetings and larger departmental meetings. -
Molecular Design InternTargacept, Inc. May 2010 - Aug 2010Winston-Salem, Nc, UsWorked with the Molecular Design team to create quantitative structure-activity relationship(QSAR) models to be used to screen small molecule libraries. These QSAR models have predictive power in determining possible biological indication a compound at the organism level, as well as that compound’s possible mechanism of action at the molecular level. Presented scientific findings to internal group meetings and larger departmental meetings.
Matthew Tyson Skills
Sds Page
Protein Purification
Molecular Biology
Pcr
Cell Culture
Recombinant Dna Technology
Biopharmaceuticals
Column Chromatography
Ultrafiltration
Centrifugation
Rna Isolation
Rnai
Western Blotting
Gel Electrophoresis
Diafiltration
Vaccines
Quality By Design
Viral Clearance
Membrane Separations
Normal Flow Filtration
Tangential Flow Filtration
Ultracentrifugation
Virus Purification
Matthew Tyson Education Details
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North Carolina State UniversityMicrobial Biotechnology -
North Carolina State UniversityZoology
Frequently Asked Questions about Matthew Tyson
What company does Matthew Tyson work for?
Matthew Tyson works for Novartis Gene Therapies
What is Matthew Tyson's role at the current company?
Matthew Tyson's current role is Associate Director at Novartis Gene Therapies.
What is Matthew Tyson's email address?
Matthew Tyson's email address is ma****@****csu.edu
What schools did Matthew Tyson attend?
Matthew Tyson attended North Carolina State University, North Carolina State University.
What skills is Matthew Tyson known for?
Matthew Tyson has skills like Sds Page, Protein Purification, Molecular Biology, Pcr, Cell Culture, Recombinant Dna Technology, Biopharmaceuticals, Column Chromatography, Ultrafiltration, Centrifugation, Rna Isolation, Rnai.
Who are Matthew Tyson's colleagues?
Matthew Tyson's colleagues are Ibneet Kaur, Jessica Massone, Mark Hopkins, María José Vargas Castro, David Ives, Gustavo Zagonel Silva, Aaron Xiong.
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