Matthew Tonini Email & Phone Number

Lexington, MA, US

Boston, Massachusetts, United States

Greater Boston Area

• Currently working in a discovery research team setting with specific goals to identify, validate and optimize novel therapeutic targets and molecules to treat lysosomal storage disorders and rare genetic diseases.
• Inflammation - Developed several cell based assays to characterize morphological and biochemical properties within various leukocyte populations. Determined release levels of several cytokines (IL-10, IL-6, IL-23) and.
• Oncology - Created an antibody screening paradigm which identified and characterized several antibody libraries based on EC50 and IC50 receptor binding, NF-kB antagonism, cellular apoptosis/viability and evaluation of.
• Neuronal/Lysosomal Storage/GastroIntestinal - Worked on life cycle management programs to evaluate 2nd generation drug molecules for IND nominations. Developed and implemented assays for multiple projects and assisted.
• Gene Therapy - Identified novel SNPs associated with a mutated allele in disease cells for targeted drug delivery. Developed RT-PCR assays which assessed reduction in disease allele with therapeutic intervention.
• Novel Target Identification - Routinely perform literature searches and attend local conferences to stay current with relevant disease biology. Have introduced target ideas to management for feedback and possible.

Greater Boston Area

Transitioned to Cell Biology group to perform both In-Vitro and In-Vivo experiments for various drug discovery projects and studies. Worked to develop, troubleshoot and perform multiple cell based and biochemical assays. Responsible for characterizing the cellular uptake, activity, localization and efficacy of novel therapeutics. Kept detailed notes and.

Greater Boston Area

Performed various In-Vivo experiments to determine proof of concept for novel drug candidates. Responsible for all aspects of experiments including scheduling, data generation, record keeping, report writing, troubleshooting and data presentation. Contributed to strategic planning of projects and new research by communicating ideas and suggestions at.

Greater Boston Area

Conducted In-Vivo experiments to progress drug studies and clinical trials and became proficient in various In-Vivo techniques, assays, data analysis and lab notebook notation.

Greater Boston Area

Conducted In-Vivo testing under appropriate guidelines (FDA, EPA, GLP, ISO, AALAS).

Bachelors, Biology

Master’S Degree, Biotechnology