Matt Kelker Email and Phone Number
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R&D CAPABILITY PROFILE Biophysicist and protein chemist with direct experience in organizing start-up R&D programs and the application of chemical and physical sciences to biological systems. Successful in achieving project objectives while mentoring junior scientists and maintaining informed key stakeholders. Recognized technical leadership in structural biology, protein expression/purification, downstream processing and formulations. I enjoy building teams, collaborative environments and getting stuff done.Proven excellence in: Eukaryotic and prokaryotic protein expression covering strain development, optimization, expression, and purification from laboratory to pilot scale; implementation of corporate structural biology program to assess structure/function relationship of biotechnology products; design and commissioning of pilot scale protein production facility; junior scientist development, mentoring; Six Sigma Green Belt
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Vice President Of Research And DevelopmentXylogenics, Inc. Oct 2024 - PresentPittsboro, In, Us
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Chief Scientific OfficerHelix Biostructures 2023 - Sep 2024Indianapolis, In, Us -
Vice President Of Research And DevelpomentHelix Biostructures Jan 2022 - Apr 2023Indianapolis, In, Us• Define long term growth strategy of laboratory capabilities and operations.• Establish external collaborations and licensing.• Serve as technical lead for laboratory with two direct reports.
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Director Of Research And DevelopmentHelix Biostructures Apr 2021 - Dec 2022Indianapolis, In, UsExpand laboratory operations to encompass a broad range of expression systems, techniques and service line offerings.Gain new clients by participating in sales calls, writing contracts and customer support during the course of every project.
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Director Of Protein SciencesHelix Biostructures May 2020 - Apr 2021Indianapolis, In, Us• Grew protein production laboratory to profitability in two years.
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Chief Scientific OfficerXylogenics, Inc. 2015 - 2020Pittsboro, In, UsStart-up; yeast based synthetic biology and strain development company• Responsible for growing R&D capability and supporting team (three direct reports) with limited funding and resources.• Find novel applications for our proprietary S. cerevisiae cell factories (e.g. protein or fine chemical production) and identification of new business opportunities therein.• Establish research priorities and budgets. • Test novel strains for fermentation performance and assess metabolic profiles.• Lead Analytical Fermentation Group which models 800,000 gallon fuel ethanol fermenters at bench scale.
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Associate R&D ManagerDow Agrosciences 2009 - 2015Indianapolis, In, UsBioengineering and Bioprocess R&D, Protein Expression Group• • Built pilot scale, protein expression and downstream processing laboratory from conception to new facility buildout. • Created in-house structural biology and protein engineering capability, resulting in 90% cost reduction from previous collaboration costs.• Utilized proprietary Pseudomonas fluorescens expression technology to develop gram level expression strains; optimized fermentation scale up. As needed, Eukaryotic expression strains were developed. • Developed purification strategies (~2g – 85g) for >20 targets to support global Regulatory submissions and environmental safety assessments.• Determined unique protein formulations (cryo-preservatives or excipients) to ensure long term stability (3-10 years) and activity retention in liquid or lyophilized powder form. -
Post Doctoral Research FellowBrown University 2005 - 2009Providence, Rhode Island, UsAdvisor: Dr. Wolfgang PetiDepartment of Molecular Pharmacology, Physiology and BiotechnologyNMR and crystallographic studies of Protein Phosphatase 1 (PP1) and its binding partners• Probed PP1 inhibition mechanism by determining crystal structures of PP1:inhibitor complexes. • Created chaperone based E. coli expression strain to produce soluble PP1.• Calculated NMR structures of proteins implicated in neurological disease to study neuronal signaling and disorders.• Trained graduate and undergraduate students; received NIH post-doctoral fellowship. -
Graduate StudentThe Scripps Research Institute 2000 - 2005La Jolla, California, UsAdvisor: Dr. Ian A. WilsonDepartment of Molecular Biology and the Skaggs Institute for Chemical BiologyX-ray crystallographic studies of proteins involved in innate immunity • Developed expression strains and optimized fermentation protocols of prokaryotic, eukaryotic and mammalian heterologous expression systems.• Established purification protocols for soluble and insoluble proteins for crystallization.• Probed structure-function relationships of extracellular receptors of the innate and adaptive immune systems using biophysical techniques.• Created and delivered lectures on the biology of Chemical and Biological Warfare to high school teachers and students. -
Lab Tech.Purdue University 1999 - 2000West Lafayette, In, UsAdvisor: Dr. Barb GoldenDepartment of BiochemistryX-ray crystallographic studies of catalytic RNA and RNA complexes• Used in vitro translation to produce and purity structural RNAs.• Crystallize RNA and RNA complexes and collect data.• Collaborate with graduate students and lead several independent projects. -
Undergraduate ReseacherPurdue University 1998 - 1999West Lafayette, In, UsAdvisor: Dr. Jeffrey BolinDepartment of Biological SciencesX-ray crystallographic studies of metalloenzymes• Crystallized dioxygenases under anaerobic conditions, collected data and determined crystal structures to understand mode of action against polychlorinated biphenyls.
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Undergraduate Honors Thesis ResearchPurdue University 1996 - 1998West Lafayette, In, UsAdvisor: Dr. D. James MorréDepartment of Medicinal Chemistry and Molecular Pharmacology Thesis: “Heat and protease resistant glyceraldehyde 3-phosphate dehydrogenase from HeLa cells.” • Determined that the tNOX protein has prion-like properties.
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Exchange StudentCardiff University Jun 1998 - Aug 1998Cardiff, Wales, GbAdvisor: Dr. Peter KilleBiosciences DepartmentBioremediation; expression and kinetic binding analysis of mutant metallothioneins • Expressed, purified and assayed metallothionein constructs for increased heavy metal binding affinities.
Matt Kelker Skills
Matt Kelker Education Details
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Scripps ResearchBiophysics/Structural Immunology -
Purdue UniversityMolecular Biology
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Purdue UniversityMolecular Biology
Frequently Asked Questions about Matt Kelker
What company does Matt Kelker work for?
Matt Kelker works for Xylogenics, Inc.
What is Matt Kelker's role at the current company?
Matt Kelker's current role is Vice President of Research and Development at Xylogenics..
What is Matt Kelker's email address?
Matt Kelker's email address is ma****@****met.com
What is Matt Kelker's direct phone number?
Matt Kelker's direct phone number is (989) 633*****
What schools did Matt Kelker attend?
Matt Kelker attended Scripps Research, Purdue University, Purdue University.
What are some of Matt Kelker's interests?
Matt Kelker has interest in Science And Technology, Children.
What skills is Matt Kelker known for?
Matt Kelker has skills like Protein Chemistry, Biochemistry, Protein Purification, Molecular Biology, Purification, Protein Expression, Biotechnology, Dna, Life Sciences, Assay Development, X Ray Crystallography, Cell.
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