Highly experienced translational tumour immunologist passionate about bringing transformative medicines to patients with cancer. Currently Director of Disease Biology at Peptone, leading a team of Biologists responsible for executing in vitro studies to support all aspects of preclinical development for novel biologic and small molecule therapeutics. Project Leader for two programmes; an engineered cytokine-mAb fusion in preclinical studies currently executing IND-enabling in vivo studies, and a novel small molecule campaign against a key oncology transcription factor in the early stages of target validation. Leading cross-functional teams, in addition to supporting the wider organisation as an expert drug discovery resource contributing to the mode of action work and building disease rationale for projects across the portfolio. Accountable for making quick and informed decisions, driving programmes forward by contributing to strategy, data review, delivering internal and external international presentations and leading key stakeholder management. Familiarity and enjoyment with working in a fast-growing matrixed international biotech environment, managing relationships and teams at all levels of a company hierarchy.I have a strong academic background in molecular genetics, tumour biology and immunology receiving my PhD at the University of York and completing post-doctoral training at the University Cambridge. Deep technical expertise across all aspects of translational biology, including advanced flow cytometry, in vitro 3D tissue culture systems, advanced microscopy and multiple in vivo pre-clinical model systems. I retain an avid fascination regarding stromal immunology and was the Co-founder and President of the Stromal Immunology Group, an official affinity group of the British Society of Immunology, for more than a decade.
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Vp Of R And DSalvina TherapeuticsUnited Kingdom -
DirectorPeptone Nov 2023 - PresentLondon, England, Gb• Project Lead for engineered cytokine-mAb fusion, an optimised cytokine, and a novel small molecule inhibitor of a key oncogenic transcription factor.• Responsible for shaping new target(s), project strategies and acting as an expert drug discovery resource across the portfolio.• Leading investigational mode of action work whilst building disease rationale and clinical differentiation for more advanced projects.• Leading multi-disciplinary teams to deliver from Hit ID to drug candidate.• Employing translational experience to define and build strategic plans for IND-enabling activities.• Building and leading effective partnerships with CROs and academic partners to ensure optimum productivity, engagement and delivery on timelines. -
DirectorF-Star Therapeutics, Inc. Jul 2022 - Nov 2023Cambridge, Cambridgeshire, GbExecutive Project Leader and Scientific Lead for FS222 (CD137/PD-L1 tetravalent bispecific antibody) responsible for taking this program through First in Human clinical trials.Leader of multidisciplinary cross-functional project teams responsible for preclinical in vitro and in vivo biology, clinical pharmacology, translational medicine and clinical development, CMC, regulatory affairs, and clinical operations.Defined the strategic priorities effectively communicating these to relevant cross-functional, subject matter experts in order to meet tight timelines to deliver on project objectives and corporate goals. -
Senior Principal ScientistF-Star Therapeutics, Inc. Mar 2021 - Jul 2022Cambridge, Cambridgeshire, GbScientific Lead on two of our clinical stage CD137-based bispecific antibodies. Responsible for developing and overseeing scientific aspects within the Preclinical Translational Pharmacology function, leading the definition and implementation of the CD137 research strategy. Associate Project Leader for FS222, F-star's potentially best-in-class CD137/PD-L1 clinical stage bispecific antibody. -
Principal ScientistF-Star Therapeutics, Inc. Mar 2019 - Mar 2021Cambridge, Cambridgeshire, GbExecutive Project Leader responsible for taking a preclinical project from Candidate Selection to First in Human clinical trials. I lead a multidisciplinary cross-functional project team consisting of functional leads from preclinical in vitro and in vivo biology, clinical pharmacology, translational medicine, CMC, regulatory affairs, and clinical operations. I make clear decisions on project direction by gaining input from the functional sub-teams, create an open forum for discussion to identify challenges and promote creative problem solving. An important part of this role is to define the strategic priorities and communicate these effectively to relevant cross-functional, subject matter experts in order to meet tight timelines to deliver on project objectives and corporate goals.Being a member of the Preclinical Translational Pharmacology department, I am also scientific lead on a number of projects and sit on many cross-functional sub-teams. -
Senior ScientistF-Star Therapeutics, Inc. Sep 2017 - Mar 2019Cambridge, Cambridgeshire, GbBiology and Scientific Lead on FS222, a potential best-in-class CD137/PD-L1 bispecific antibody candidate in immune-oncology. I was Project Leader from Discovery phase to Candidate Selection and then transitioned to Biology Lead on the core project team to run the IND-enabling preclinical activities encompassing a multitude in vitro assays and several efficacy and pharmacodynamic syngeneic in vivo models. I have presented this project at several conferences (SITC, Nov 2018; ESMO-IO, Dec 2019; AACR, March 2019; AACR, June 2020) and continue to work on this exciting asset in my role as Scientific Lead. This work has just been published in Clinical Cancer Research: https://clincancerres.aacrjournals.org/content/early/2020/06/12/1078-0432.CCR-19-2958.full-text.pdf -
ScientistF-Star Therapeutics, Inc. May 2015 - Sep 2017Cambridge, Cambridgeshire, GbF-star develops bispecific antibody products to improve the treatment of cancer. F-star is the only biopharmaceutical company creating bispecific antibodies by modifying the constant region of an antibody. Our Modular Antibody Technology offers unprecedented ease in the development and manufacturing of genuine bispecific antibody products. In my role as Scientist I experienced early discovery work on a number of targets, including those against immune checkpoint blockade and key immune cell agonist receptors such as CD137 (4-1BB). I was responsible for initiating a CD137 based therapeutic which is now in late stage preclinical development, with applications to the regulatory authorities to start a first in human phase I clinical trial expected to be submitted this year (2020). -
PresidentBsi Stromal Immunology Group Nov 2010 - Nov 2020With Dr Ben Owens, I co-founded and presided over the Stromal Immunology Group (StIG), an official Affinity Group of the British Society for Immunology.The group aimed to extend the awareness of, and integration between, the fields of immunology and stromal cell biology. We held, sponsored, and were involved in several global conferences with high caliber international speakers.The group coordinated the publication of the first ever textbook in the field ‘Stromal Immunology’, published by SpringerNature in Autumn 2018.
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Career Development FellowUniversity Of Cambridge May 2012 - May 2015Cambridge, England, GbAt the Medical Research Council (MRC) Cancer Unit I worked at the interface of lymphatic biology, the tumour microenvironment (TME) and immunology. Utilising a multidisciplinary approach that integrated molecular biology, tissue-engineered 3D in vitro systems and in vivo models, I worked towards determining how tumour microenvironment (TME) contributed to tumour development. My research specifically focussed on the interaction of cancer-associated fibroblasts (CAFs) with antigen-specific CD8+ T cells in the TME. -
PhdUniversity Of York Apr 2009 - May 2012York, Gb"The role of stroma microenvironments in prostate cancer cell growth, migration and metastasis"I utilised 4-D, 2-photon time-lapse microscopy within a 3D in vitro tumour microenvironment model, in order to observe the effect of different culture conditions, cell types and 3D matrix on the migration of cancer related cells. In particular, I worked on the impact of stromal cells (cancer-associated fibroblasts, CAFs) on cancer cell migration which was amplified under inflammatory conditions. -
Senior Research TechnicianUniversity Of York Aug 2005 - Apr 2009York, GbDuring this time I worked on 5 different projects:“LPS modification in Salmonella biology” with Dr Marjan van der Woude and Dr Mark Davies. Responsibilities included creating a bank of genetic knockouts for LPS modification genes.“Imaging cancer migration utilising multi-photon laser scanning microscopy” with Dr Mark Coles. Named researcher investigating the migration of fibrosarcoma cells within the extracellular matrix in collaboration with AstraZeneca.“Exploiting MP-LSM as an imaging and manipulation tool to study biofilms” with Dr Marjan van der Woude and Dr Peter O’Toole. Named researcher on this 6 month BBSRC funded Tools and Development grant.“UPEC invasion of bladder epithelial cells” with Dr Marjan van der Woude and Professor Jenny Southgate.“Genetic Analysis of bacterial biofilm formation” with Dr Marjan van der Woude.During my time at the Centre for Immunology and Infection, I was involved in multiple projects and developed a wide range of skills: - Microbiology, mammalian tissue culture and both cell and molecular biology - Hardware development of in-house microscopes - Management of own independent lab research project(s) - Trained on instruments including Zeiss 780 Meta NLO Multiphoton microscope -
Bsc UndergraduateUniversity Of Sussex Sep 1999 - Jun 2003Brighton, East Sussex, GbBSc (Hons) Molecular Genetics in Biotechnology [sandwich]With 1 year in industry working at Genetix Ltd, New Milton, Hampshire -
Lab TechnicianGenetix 2001 - 2002New Milton, Hampshire, GbA one year position as part of my 4 year Molecular Genetics BSc, I developed a high throughput PCR clean-up kit. Also responsible for the QC and production of the current kits which would reach in to the thousands each month.
Matt Lakins Skills
Matt Lakins Education Details
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University Of YorkProstate Cancer -
University Of SussexMolecular Biology
Frequently Asked Questions about Matt Lakins
What company does Matt Lakins work for?
Matt Lakins works for Salvina Therapeutics
What is Matt Lakins's role at the current company?
Matt Lakins's current role is VP of R and D.
What schools did Matt Lakins attend?
Matt Lakins attended University Of York, University Of Sussex.
What are some of Matt Lakins's interests?
Matt Lakins has interest in Science And Technology, Health.
What skills is Matt Lakins known for?
Matt Lakins has skills like Imaging, Cell Culture, Molecular Biology, Flow Cytometry, Tissue Culture, Stem Cells, Microbiology, Qpcr, Cell, Microscopy, Digital Imaging, Cell Biology.
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