Mchardy Smith Email and Phone Number
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Professor of Pharmacology. Teaching pharmacology and toxicology to graduate students, Pharm D candidates and to BS Pharmacology and Toxicology students. Focus is on communicating technical information by using student's existing frames of reference and active learning. Responsible for curriculum development and course design.Senior Research Scientist in Membrane Biochemistry & Biochemical Pharmacology. Skilled leader with over 20 years industry experience at Merck & Co. Committed to focused drug discovery and development through teamwork and critical thinking with a record of success from discovery to preclinical. Experienced in membrane based mechanisms across most therapeutic areas including animal health and crop protection applications. Major driver of Medicinal Chemistry and HTS campaigns.Relocation is not an issue.Specialties:HTS/uHTS assay development & follow-up for medicinal chemistry programsIndustrial grade statistical tools for assay quality controlDirecting, mentoring and guiding researchProtein purification: 1ary, 2ary, 3ary & 4ary structure determinationG-protein coupled receptorsLigand-gated & Voltage-gated ion channels Enzyme hysteresis, slow binding & irreversible inhibitorsLigand binding, ELISA & enzymatic assays, Immunochemistryhttp://www.ncbi.nlm.nih.gov/myncbi/1jaPhdKxmeiAi/cv/994/
Lecom - Bradenton
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Associate Professor Of PharmacologyLecom - Bradenton Jun 2013 - PresentBradenton, FlTeaching Pharmacology, Pharmacogenomics of Oncology & Drug Discovery and Development.Navigating the software package R in order to finish a paper.
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Visiting Full ProfessorUniversity Of The Sciences Aug 2011 - Jun 2013Greater Philadelphia AreaCourse Coordinator for Pharmacology I and for Biochemical Pharmacology and ToxicologyTeaching Pharmacology and Toxicology.Also taught at Middlesex County College, teaching Human Anatomy and Physiology.Navigating the software package R in order to finish a paper.Mentoring and curriculum development at Students2Science, a science-enrichment program giving middle and high school students real laboratory experiences. -
Sr Research FellowMerck 2000 - 2008Biochemical experimentation leading towards clinical drug discovery. Continued work on Nodulisporic acid receptor in invertebrates. Continued work on peptide toxin blockers of Kv2.1 (GxTx-I) and Nav 1.7 (ProTx-II). Finished up HTS campaign on Nav 1.7 using FLIPR and VIPR using FRET dyes. Started an N-type calcium channel screening campaign including counterscreening using FLIPR 384 and Ca dyes.Scientific lead in developing a basic research data analysis tool adopted company-wide. Major driver in writing "Fluorescent plate readers: Merck Best Practices". -
Research FellowMerck 1994 - 2000Identified the mechanism of action of a novel fungal product (nodulisporic acid) with insecticidal activity - it potentiated the opening of the invertebrate glutamate-gated chloride channel. I also found that the Drosophila melanogaster Glutamate-gated chloride channel co-immunoprecipitated with a subunit of the GABA-gated chloride channel. Ran three HTS campaigns on nodulisporic acid and Ivermectin binding sites in invertebrates.Setup and ran a high-throughput screening (HTS) assay using the human sodium channels Nav 1.7 and 1.8 on a VIPR using FRET dyes. Purified and determined the primary and secondary structure of spider toxins blocking Nav 1.7 and Kv2.1. They are cystine-knot peptides that block by shifting the voltage-dependence of channel activation to a more positive potential.Led program to automate reading of larval death assays. Ended a 6 yr term on Merck Research Laboratories Rahway Site Safety Committee with last yr as Chair of same.
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Senior Research BiochemistMerck Sep 1988 - 1994From spider venom, I identified several activities of interest. I purified to homogeneity an invertebrate-selective sodium channel activator and several calcium channel blockers. Activities were traced by functional assays, electrophysiological assays and by conotoxin binding assays. Proteins were purified by reverse phase and Ion exchange HPLC. Purified peptides and proteins were used as proof-of-concept molecules and as tools for basic science research. Purified proteins were sequenced.The HPLC data was acquired using a program built in LabVIEW. The program monitored and recorded absorbance (up to 4 wavelengths), back pressure and %B, and controlled 2 fraction collectors.
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Postdoctoral FellowWashington University School Of Medicine Jun 1984 - Aug 1988Biosynthesis and Assembly of the subunits of the nicotinic Acetylcholine receptor in the lab of Dr. John Paul Merlie. Also studied phosphorylation of the nicotinic acetylcholine receptor in intact cells in the lab of Dr. John Lawrence.
Mchardy Smith Skills
Mchardy Smith Education Details
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Cell Biology/Biochemistry
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Pharmacology -
Psychology
Frequently Asked Questions about Mchardy Smith
What company does Mchardy Smith work for?
Mchardy Smith works for Lecom - Bradenton
What is Mchardy Smith's role at the current company?
Mchardy Smith's current role is Assoc Professor of Molecular Pharmacology.
What is Mchardy Smith's email address?
Mchardy Smith's email address is mchardysmith@me.com
What is Mchardy Smith's direct phone number?
Mchardy Smith's direct phone number is +173259*****
What schools did Mchardy Smith attend?
Mchardy Smith attended Washington University School Of Medicine In St. Louis, University Of North Carolina At Chapel Hill, University Of Vermont.
What are some of Mchardy Smith's interests?
Mchardy Smith has interest in Education, Children.
What skills is Mchardy Smith known for?
Mchardy Smith has skills like Drug Discovery, Assay Development, Biochemistry, Pharmacology, Protein Chemistry, Cell, Enzyme Assays, Western Blotting, Lifesciences, Protein Purification, Life Sciences, Clinical Development.
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