Mariappan Chelliah Email & Phone Number

• Extensively contributed to the ongoing development of a drug candidate to treat type-2 diabetes.• Planned and coordinated animal efficacy studies with an external CRO.• Designed chemistry experiments and solved problems for chemists working at a CRO firm that Merck was collaborating with.• Co-invented a best-in-class drug candidate to treat patients infected with hepatitis C virus. • Made key innovation to improve the pharmacokinetic profile that resulted in the discovery of a best-in-class HCV clinical candidate.

• Inventor of a pre-clinical drug candidate to treat obesity that works by CB1 receptor antagonism. • Led a technology transfer and played a leadership role collaborating with a CRO and the process group to successfully advance the CB1 program from the lab to pilot scale.• Played a central role in a collaborative program between Schering-Plough and Mochida Pharmaceuticals (Japan) to discover an anticoagulant drug to treat atrial fibrillation.• Inventor of pyrimidine analogs as fIXa inhibitors.• Inventor of cyclic amidine analogs as fIXa inhibitors.

• Recipient of Schering Plough Research Institute’s President Award for innovation and the discovery of Vorapaxar.• Co-inventor of Vorapaxar, a first-in-class PAR-1 antagonist to treat acute coronary syndrome. Vorapaxar was recently approved by the FDA.• Solved key enzyme induction, metabolite accumulation and clearance issues shown by the prior development candidates which ultimately led to the discovery of Vorapaxar. • Inventor of a best-in-class back-up pre-clinical candidate to Vorapaxar. • Inventor of nor-seco himbacine analogs as potent PAR-1 antagonists.• Inventor of hetero-himbacine analogs as potent PAR-1 antagonists.

• Contributed to the successful total synthesis of himgaline, a complex alkaloid natural product at Schering-Plough. Chemistry developed in this total synthesis was subsequently applied to the synthesis of constrained analogs of himbacine as PAR-1 antagonists.

Phd, Organic Chemistry

Msc, Chemistry

Bsc, Chemistry