Mehrdad (Mike) Shadmehr Email and Phone Number
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I am an organic chemist with extensive experience with design, synthesis, purification (including different types of chromatography), and characterization (including different types of instrumental analysis) of small molecules and fluorescent probes for chemical biology, drug delivery, and medicinal chemistry purposes. I also have experience with bioconjugation of small molecules for fluorescent labeling of peptides and proteins.
Thermo Fisher Scientific
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Supervisor Of Formulation And ManufacturingThermo Fisher Scientific Sep 2023 - PresentWaltham, Ma, Us•Lead and manage a team of fifteen senior and junior chemists in production and process development of fluorescent dyes, quenchers, nucleotides, and linkers for multiple projects in the genetic science division of Thermo Fisher Scientific and external customers. -
Technology ConsultantTheracea Pharma Dec 2022 - PresentOro Valley, Arizona, Us -
Editorial Board MemberInternational Journal Of Nanomedicine Jun 2020 - Present
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Member Of Review PanelAsian Journal Of Nanosciences And Materials Jun 2018 - Present
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Research Scientist (Bioconjugation Chemistry)Proteogenomics Research Institute For Systems Medicine (Prism) Apr 2023 - Sep 2023La Jolla , Us•Design and synthesis of novel linker for Antibody-drug conjugates (ADCs).•Synthesis, purification, and characterization of ADCs via Dialysis, SEC-UV, MALDI, etc. -
Scientist IiiThermo Fisher Scientific Nov 2021 - Dec 2022Waltham, Ma, Us•Design and synthesis of small molecules fluorophores and quenchers (multi-step synthesis).•Purification of small molecules applying different types of chromatography methods including TLC, Flash Chromatography, HPLC, UPLC, UPLC-MS.•Characterization of small molecules by different types of instrumental spectroscopy methods including NMR, MS, UV-Vis, Fluorometry. -
Postdoctoral Research AssociateUniversity Of Virginia Aug 2019 - Nov 2021Charlottesville, Va, Us• Design and synthesis of small molecule fluorogenic fluorophores.• Design and synthesis of second window near-infrared fluorophores. -
Member Of The Editorial BoardCient Periodique Medicine (Cpq Medicine) Jul 2018 - Jun 2020
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Postdoctoral Research AssociateUniversity Of Nebraska-Lincoln Jan 2018 - Jul 2019Lincoln, Ne, Us• Design and synthesis of small molecule fluorogenic fluorophores.• Design and synthesis of second window near-infrared fluorophores.• Design and synthesis of photoactivatable fluorogenic prodrug fluorophores as a drug delivery system for small anticancer molecules.• Purification of small molecules applying different types of chromatography methods including TLC, Flash Chromatography, HPLC, LCQ.• Characterization of small molecules by different types of instrumental spectroscopy methods including NMR, MS, UV-Vis, Fluorometry, IR.• Toxicity test of small molecules on different types of cell lines including Hela, Cho, and Raw cells.• Scale-up synthesis of different types of small molecule up to 50 grams.• Applying different types of software for interpretation data and prediction including ChemDraw, Chem3D, Mestrenova, Excel, etc. • Applying scientific search engines for design and discovery of new and economical synthetic routes including SciFinder, Reaxys, PubMed, etc.• Volunteer Judge of undergraduate research symposium. -
Member Of The Editorial BoardHerald Scholarly Open Access Journal Of Medicine Jun 2018 - Jun 2019
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Member Of Review Panel Section C (Chemistry)Journal Of Scientia Iranica Mar 2018 - Mar 2019
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Research And Teaching AssistantThe University Of Arizona Aug 2011 - Dec 2017Tucson, Arizona, Us• Design and synthesis of the Triazabutadiene-based coumarins and its application for fluorescent labeling of Tyrosine residues of proteins.• Design and synthesis of the coumarin-triazabutadiene as a cross-linker and a fluorophore pull-down system for characterization and purification of peptides, proteins, and Nucleic acids.• Design and synthesis of Dual-Functional triazabutadiene for surface modification. • Design and synthesis of cleavable bioorthogonal affinity tag for protein purification.• Design and synthesis of the smallest photoactive cyclooctadiyne.• Design and synthesis of a borane protected phosphine triazabutadiene as a new Staudinger reagent for Tyrosine labeling of proteins.• Design and synthesis of a cleavable fluorogenic system including Cyclooctyne triazabutadiene and azido coumarin for Tyrosine modification of proteins.• Scale-up synthesis of small molecules and fluorophores into gram scale up to 100 grams.• Purification of small organic molecules by different methods including Recrystallization, Flash chromatography, Prep-TLC, GC, HPLC, Lyophilization. • Characterization of organic small molecules by different types of instrumental analysis methods including NMR, 2D NMR, IR, GC, GC-MS, React-IR, MS, LC-MS, UV-Vis• Scale-up synthesis of different types of small molecule up to 50 grams.• Applying different types of software for interpretation data and prediction including ChemDraw, Chem3D, Mestrenova, Excel, etc. • Applying scientific search engines for design and discovery of new and economic synthetic routes including SciFinder, Reaxys, PubMed, etc.• Mentoring and training undergraduate researcher and new graduate students• Research assistant of NMR facility, helping for the maintenance of all of the NMR machines of chemistry and biochemistry department, running samples of undergraduate and graduate level teaching labs.• Teaching undergraduate and graduate level of organic chemistry and organic chemistry labs -
Organic Chemist InternIcagen Jul 2016 - Aug 2016
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Organic Chemist InternSanofi May 2016 - Aug 2016Paris, France, Fr• Synthesis of a library of drug candidate organic small molecules (piperazinone derivatives) for PMP22 inhibition as a therapeutic approach for Charco-Marie-Tooth disease type 1A.• Purification and characterization of organic small molecules applying different instrumental methods including Chromatography, HPLC, LC-MS, NMR.• Applying different types of software for interpretation data and prediction including ChemDraw, Chem3D, Mestrenova, Excel, etc. • Applying scientific search engines for design and discovery of new and economical synthetic routes including SciFinder, Reaxys, PubMed, etc. -
Research And Teaching AssistantSouthern Illinois University Edwardsville Feb 2009 - Jun 2011Edwardsville, Illinois, Us• Design and synthesis of a library of a fluorinated bioactive small heterocyclic molecule (fluoro-isoxalidine and fluoro-pyrrolidine).• Purification of small organic molecules by different methods including Recrystallization, Flash chromatography, Prep-TLC, GC. • Characterization of small organic molecules by different types of instrumental analysis methods including NMR, 2D NMR, IR, GC, MS, UV-Vis.• Applying different types of software for interpretation data and prediction including ChemDraw, Chem3D, Mestrenova, Excel, ACD lab. • Applying scientific search engines for design and discovery of new and economic synthetic routes including SciFinder, Reaxys, PubMed, etc.• Mentoring and training undergraduate researcher and new graduate students.• Teaching undergraduate level of general chemistry and organic chemistry labs. -
Research And Teaching AssistantUniversity Of Tehran Oct 2004 - Aug 2008Tehran, Tehran, IrResearch Assistant Synthesis of Azalactone Via Darzene type reactions Teaching Assistant, Biochemistry lab, undergraduate levelTeaching Assistant Nutrition Chemistry lab, undergraduate level
Mehrdad (Mike) Shadmehr Skills
Mehrdad (Mike) Shadmehr Education Details
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University Of ArizonaOrganic Chemistry -
Southern Illinois University EdwardsvilleFluorine Chemistry -
University Of TehranChemistry
Frequently Asked Questions about Mehrdad (Mike) Shadmehr
What company does Mehrdad (Mike) Shadmehr work for?
Mehrdad (Mike) Shadmehr works for Thermo Fisher Scientific
What is Mehrdad (Mike) Shadmehr's role at the current company?
Mehrdad (Mike) Shadmehr's current role is Supervisor of Formulation and Manufacturing at Thermo Fisher Scientific.
What is Mehrdad (Mike) Shadmehr's email address?
Mehrdad (Mike) Shadmehr's email address is me****@****her.com
What schools did Mehrdad (Mike) Shadmehr attend?
Mehrdad (Mike) Shadmehr attended University Of Arizona, Southern Illinois University Edwardsville, University Of Tehran.
What are some of Mehrdad (Mike) Shadmehr's interests?
Mehrdad (Mike) Shadmehr has interest in Science And Technology, Education, Chemistry.
What skills is Mehrdad (Mike) Shadmehr known for?
Mehrdad (Mike) Shadmehr has skills like Nmr, Organic Chemistry, Uv/vis, Chemistry, Organic Synthesis, Spectroscopy, Analytical Chemistry, Mass Spectrometry, Hplc, Medicinal Chemistry, Chromatography, Biochemistry.
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