Meilan He Email & Phone Number

San Diego, Ca, Us

San Diego, Ca, Us

Collaborate with cross-functional teams to generate, analyze, and communicate clinical biomarker data for Allo Car T cell therapy trials.

Greater San Diego Area

Develop, validate and execute biomarker and diagnostic strategies to inform decision making for various therapeutic modalities in collaborating with diverse stakeholders. • Led the development and validation of patient stratification biomarker and diagnostic strategies in close collaboration with preclinical and clinical teams. Produced comprehensive biomarker reports that facilitated analysis from preclinical to clinical samples, including establishment of threshold lines. Provided support for publication efforts. • Executed clinical biomarker sample analysis from data generation to comprehensive analysis (targeted NGS and Olink NGS) within a GCLP-compliant lab, effectively communicated data with study teams to inform potential resistance mechanisms and biomarker strategies, supported study-level clinical documents.• Evaluated the clinical utility of diverse technologies, such as spatial technologies, single immune cell secretion, cell-free DNA assessment, strategically aligned them with targeted biomarker inquiries. • Assessed contract labs and managed multiple biomarker assays, ensuring the timely delivery of high-quality data. Demonstrated a solid understanding of quality control procedures and troubleshooting skills.• Exhibited robust analytical skills in biomarker data analysis, interpretation and presentations, reinforced by a 2-year secondment within the bioinformatics teams.

Greater Los Angeles Area

Developed and transferred companion diagnostic assays and ensured high-quality data and efficient operation for CROs service.• Successfully implemented customized NGS, PCR and sanger sequencing assays, addressing companion diagnostic intricacies and optimizing the delivery of high-quality data and diagnostic report.• Developed companion diagnostic assays, creating Standard Operating Procedures (SOPs) and validation reports, and facilitated the transfer of the diagnostic assay for clinical implementation. • Managed key customer’s CRO service for FFPE samples to ensure the delivery of high-quality data. established and nurtured strong customer relationships through effective project management, clear scientific and technical communication, and timely delivery of services.• Developed and implemented thorough QC criteria covering DNA/RNA QC, library QC, and sequencing QC, driving enhanced data quality and business growth. Contributed to streamlining detail QC data recording and sharing to improve operation performance. • Supported computer science team to integrate diverse datatype into Laboratory Information Management System (LIMS) to enhance the operation efficiency.

Los Angeles

Led diverse translational projects with a focus on target discovery and mechanism of action (MOA) studies. • Established innovative operational platforms in the laboratory, including the development of an animal efficacy monitoring system for drug evaluation, and the integration of NGS and genetic engineering, significantly enhancing research capabilities.• Identified epigenetic drivers for cancer therapy through analyzing, integrating and leveraging ChIPseq, RNAseq and CRISPR functional genomic screening data in collaboration with bioinformatic experts.• Investigated the MOA involved in targeting epigenetic drivers from in vitro to in vivo studies. Conducted various molecular and cellular assays, including flow cytometry, immunoprecipitation, immunohistochemistry, and immunofluorescence-based assays.• Mentored and coached junior staff, fostering collaboration and enhancing team development.

Postgraduate Degree, Cancer Biology And Immunology

Ph.D, Molecular Biology

Bachelor'S Degree, Clinical Medicine