Melanie Doyle-Eisele Email & Phone Number

Albuquerque, Nm, Us

Albuquerque, New Mexico Area

In addition to the tasks below I now oversee the toxicology and B3 technicians, necropsy group, scheduling group, and the Study Directors at our South Campus.

Albuquerque, New Mexico Area

Dr. Doyle-Eisele is involved in various GLP and non-GLP pharmaceutical pre-clinical toxicological studies at LRRI that evaluate the acute toxicity, deposition, pharmacokinetics, and efficacy utilizing a variety of respiratory disease models. Respiratory disease models evaluated include LPS COPD models (mice, rats, ferrets and non-human primates), bleomycin sulfate IPF models (rat and mouse), radiation IPF model (mouse), cigarette smoke COPD models (mice and non-human primate), and acute lung injury (ALI) models (non-human primate). Additional research includes pharmacokinetics and ADME studies evaluating various chemicals/pharmaceuticals (radiolabeled and non-labeled). Dr. Doyle-Eisele’s other efforts have utilized her experience prior to LRRI with environmental chambers and toxicology to develop, characterize, and operate the Lovelace indoor environmental chamber to examine the toxicity of biogenic and anthropogenic air pollutants.Dr. Doyle-Eisele is also working within the Center for Countermeasures Against Radiation to investigate radionuclude dosimetry, radiobiology, and toxicology in mice, rats, dogs, and minipigs. This research includes model validation of wound, inhalation, and intravenous models of contamination that were later utilized for efficacy evaluation. Additional models associated with investigating the acute radiation symndome (hemopoetic and gastrointestinal) associated with total body irradiation (TBI) in mice, non-human primates and mini-pigs were established and have been utilized to evaluate mitigating agents. The TBI minipig model has been combined with a thermal injury model (wound bed) to optimize a dual injury model integrating split thickness sking grafting and wound induction after a full thickness thermal burn in irradiated animals.

Studied 1,3-butadiene, isoprene and methanol, looking at the chemistry, modeling, and human health aspects.Ran experiments to analyze the photochemical transformation products of 1,3-butadiene and isoprene.Developed an in vitro exposure system to evaluate the toxic effects of air pollutants using an air-liquid interface.Analyzed cytotoxicity and cytokine response induced by 1,3-butadiene, isoprene, methanol and their photochemical degradation products using cultured human respiratory epithelial cells.Established, organized and manage in vitro laboratory at UNC facility.Developed a preconditioning method to model whether repeated ozone exposures modify the responses to hazardous air pollutant mixtures that are commonly present in urban smog, thus examining the response from repetitive pollutant exposures.Investigated if the toxicity induced by in vitro exposures to photochemically reactive mixtures was modified through depletion and supplementation of intracellular glutathione.Updated an explicit model by combining MORPHO reaction schemes with the Master Chemical Mechanism (MCM).Simulated the photochemical transformations of 1,3-butadiene and isoprene.Used this program to study, model, and describe the atmospheric chemistry of ozone and other photochemical oxidants used in the One Atmosphere Health effects research.Prepared official progress reports and updated abstracts for current projects funded through the ACC Long Range Research Initiative and EPA One Atmosphere research program.PM Center proposal for EPA: Attended PM Center Proposal meetings discussing the abilities of the UNC team and proposal development. Formatted the final documentation for this submission.

Assisted in using natural radioisotopes as tracers of geological and oceanographic processes by measuring the decay of uranium and thorium in the environment.Collected groundwater, river water and sea water samples using a manganese fiber filtration system.Measured isotope concentrations using high resolution gamma spectrometer systems and liquid scintillation counters.Ran all day-to-day activities associated with Dr

Phd, Inhalation Toxicology And Atmospheric Chemistry

M.S, Environmental Sciences And Engineering

Ph.D, Environmental Sciences And Engineering

B.S, Science And Mathematics In Chemistry) 2002