Melanie Lam Email and Phone Number

Lead Discovery at Global Health DA | Sept. 2024 - Present° Conduct high-throughput mass spectrometry biochemical assays to identify inhibitors targeting Plasmodium enzymes.° Develop fungicidal assays against Cryptococcus neoformans.Open Innovation at Global Health DA | Sept 2023- Sept 2024° Using HaloTag technology to study host-directed targeted protein degradation against Plasmodium berghei PVM proteins

Open Innovation at Global Health DA° Host-driven targeted degradation of malaria liver stage° Using CLEM methods to characterize the ultrastructural features of malaria liver stages ° Identification of of host pathways involvd in the liver stage of Plasmodium berghei (Pb)

° Co-lead weekly study group sessions for undergraduate students in the Biology Scholars Program (BSP) that are enrolled in the introductory biology lab course (Bio1AL) at UC Berkeley. ° Prepare lecture review material, mock quizzes and practice questions, and host office hours.

Department of Molecular, Cell Biology and Plant & Microbial BiologyProfessor Daniel Portnoy° Project: Regulation of Virulence in Listeria Monocytogenes° Used transposon mutagenesis library in MACK/10403S Listeria backgrounds and screened for mutants on egg containing agar plates. ° Characterization of mutants and mutant analysis.° Investigation of the role of stressosome and its components in Listeria virulence.

° Company is interested in discovering and developing functional antibodies for human GPCR therapeutic targets. ° Their Functional Antibody Selection Technology (FAST) Platform is used to identify functional antibodies that modulate the target GPCR.° Project Goal: False Positive reduction in their FAST platform. ° Determine if alternating between selection and counter selection will reduce the false positive rate being detected,

Department of Molecular & Cell BiologyPrincipal Investigator: Daniel Portnoy ° Prepare liquid media, pour agar plates, operate the autoclave, and handle glassware and biohazard waste.

° Assemble swab kits for the UCB COVID-19 testing sites and partner organizations.° Prepare collection tubes with RNA shield for swab kits in a PCR hood.

° A recovery initiative on the UCB campus that provides free asymptomatic saliva testing for UC Berkeley personnel and members. ° Kiosk position: Prepared & assisted with human specimen collection for further analysis and trained new volunteers & staff members.

University of California, San Francisco Mission Bay Department of Biochemistry & BiophysicsProfessor Joe DeRisi° Conducted metagenomic sequencing research on bat stars for 10 weeks to detect pathogens associated with sea star wasting disease. ° Presented my research during a lab meeting at the end of summer.

UCSC Science Internship Program Department of Molecular, Cell, and Developmental Biology Professor Melissa Jurica and Dr. Tonio Schuetze° Engineered the C2C2 RNA-binding protein as a molecular tool for RNA research ° Expression and Analysis of C2C2 RNA-binding protein.° Presented my research to a crowd of parents, mentors, and summer interns.