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-Group Leader - Separations and Compendials Methods, Development Sciences, CMC Biologics, Analytical and Research Development-Analytical Lead of early and late stage biotherapeutic programs-Results-driven and passionate technical development scientist with 20 years of analytical development experience in the biopharmaceutical industry.-Highly skilled in characterizing recombinant proteins using a variety of chromatographic, electrophoretic and mass spectrometric techniques to support process development, research projects, investigations and control systems. -Mass spectrometry SME with extensive experience on the use and maintenance of several LC-MS instrument platforms and software, and applications involving peptide mapping, intact proteins, detection of low-level sequence variants, characterization of product related variants and post-translational modifications (PTMs), and development of multi-attribute methods (MAM) for QC. -Champion for innovation, technical development, efficiency and continuous improvement.
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Principal Research Scientist IiAbbvie Jul 2023 - PresentNorth Chicago, Illinois, Us -
Principal Research Scientist IAbbvie Jul 2019 - Jul 2023North Chicago, Illinois, UsAnalytical lead of early-stage programs in Oncology Early Development (OED) CMC
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Technical Development ScientistGenentech Jan 2008 - Jul 2019South San Francisco, California, Us• Analytical lead for early-stage programs. Authored and reviewed IND sections, technical reports, test methods, validation protocols and reports, and data packages. • Subject matter expert on a diverse set of Mass Spec applications particularly involving peptide and protein analysis. Extensive experience on the operation and maintenance of various mass spectrometers. Managed several instruments, laboratories and training of MS users with different levels of expertise. • Co-led the development of peptide map UHPLC-MS as a multi-attribute method (MAM) and its strategic implementation into QC. • Developed and implemented novel approaches to advance and streamline a complex peptide map LC-MS/MS workflow for sequence variant analysis (SVA). • Provided analytical support and developed analytical methods to aid in the development of numerous early- and late-stage molecules using a variety of chromatographic, electrophoretic and mass spectrometric techniques. • Former member of a cross-functional team focused on developing and implementing several innovations programs in technical development. • Designed and implemented several initiatives to improve and accelerate work processes involving mass spectrometry. -
Development Associate IiPdl Biopharma Feb 2004 - Jan 2008Us-Provided LC-MS support to various groups in research and development -Co-managed a mass spectrometry laboratory which included regular maintenance and general troubleshooting of equipment-Developed and implemented LCMS-based methods for the characterization of MAbs and related degradation products-Developed, optimized, and validated analytical methods -
Undergraduate InternUc Davis, Division Of Rheumatology/Allergies And Clinical Immunology Mar 2003 - Dec 2003
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Summer InternProtein Design Labs Jun 2003 - Sep 2003Developed a HPLC-CEX method to characterize mAb charge heterogeneity and analyzed charge variants using a variety of analytical techniques
Melissa Alvarez Skills
Melissa Alvarez Education Details
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University Of California, DavisBiochemistry And Molecular Biology -
University Of California, DavisBiochemistry And Molecular Biology
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California State University - East BayChemistry
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California State University - East BayChemistry
Frequently Asked Questions about Melissa Alvarez
What company does Melissa Alvarez work for?
Melissa Alvarez works for Abbvie
What is Melissa Alvarez's role at the current company?
Melissa Alvarez's current role is Principal Research Scientist II at AbbVie.
What is Melissa Alvarez's email address?
Melissa Alvarez's email address is al****@****ene.com
What is Melissa Alvarez's direct phone number?
Melissa Alvarez's direct phone number is +165046*****
What schools did Melissa Alvarez attend?
Melissa Alvarez attended University Of California, Davis, University Of California, Davis, California State University - East Bay, California State University - East Bay.
What skills is Melissa Alvarez known for?
Melissa Alvarez has skills like Protein Chemistry, Mass Spectrometry, Chemistry, Hplc, Monoclonal Antibodies, Lc Ms, Biochemistry, Analytical Chemistry, Characterization, Bioanalysis, Laboratory, Biopharmaceuticals.
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