Melissa Corso Minderman Email & Phone Number

Indianapolis, Indiana Area

 Developed ELISA and lateral flow assay (LFA) IVDs from feasibility to validation with team role of subject matter expert. Designed, executed, and summarized medical device characterization and stability studies following FDA and ISO 13485 guidance and standards. Led design control activities including verification, validation, tracking and trending.

Indianapolis, Indiana Area

 Performed environmental testing in order to rapidly identify bacterial and viral public health threats. Executed and interpreted multiple real-time PCR (qPCR) assays to detect and characterize potential pathogens and ensure assay quality. Maintained chain of custody and sample integrity from DNA extraction through qPCR using aseptic BSL2 techniques..

Branford, CT

 In a technical lead role, developed DNA sequencing kit for GS Junior, a benchtop next-generation (NGS) DNA sequencer. Supervised four direct reports within R&D department, focusing on reagent formulation, optimization, guardband, stability, vendor, and protocol improvement studies. Created and maintained a record of over 1000 GS Junior sequencing.

New Haven, CT

 Executed protocol for screening of proprietary peptide display library, resulting in the identification of potential anti-tumor peptide sequences. Developed Western and ELISA methods to study peptide mechanisms of action. Investigated over 30 anti-tumor peptides using cell-based assays. Optimized RT-PCR and affinity chromatography methods to.

New Haven, CT

 Performed proprietary Whole Genome Amplification service on customer samples, up to 200 samples per day. Determined sample quantity and quality using real-time PCR and compiled data into customer reports.

New Haven, CT

 Prepared customer DNA samples for high-throughput sequencing and operated ABI 3700 DNA sequencer to process 400 samples per day. Executed quality control on products and maintained database of customer information and results.

New Haven, CT

 Supported process development for purification of lead pharmaceutical candidate using anion, cation, and hydrophobic interaction chromatography. Performed Western analysis of purification products following GLP standards.

Bethesda, MD

 As a member of a prestigious undergraduate study group, performed molecular biology research for the National Institute of Dental Research.