Work as a project Manager for the Analytical Technology Transfer activities between Internal or external sites.

LGC Biosearch Technologies, Petaluma April 2018 - PresentCustome oligonucleotide Production Manager• Managed multi-shift oligonucleotide production (purification) team and ensured availability of resources through timely and appropriate advocating • Oversee oligo production process and ensured production objectives are met in a timely manner• Ensure manufacturing priorities are completed by: process monitoring and support of production supervisors• Effectively communicated and coordinated with internal suppliers, production team members and production managers to assure the most efficient use of time and resources• Effectively coordinated with facilities and maintenance staff to ensure production equipments are functional and available for production• Managed training programs and ensured appropriate process and work instructions are in place• Worked with the production teams to identify and implement areas of continuous improvement• Managed and reported Key Performance Indicators (KPI’s)• Implemented and Managed Lean and gross margin initiatives• Manage staffing and instrumentation budgets

• Manage all QC sampling schedules and testing; ensure accurate data and lab reports are being generated from the lab in a timely manner• Schedule and oversee all QC laboratory operations and testing to approve/release all finished products, stability and raw materials tested in the laboratory• Ensure raw material and finished product testing is scheduled efficiently and in support of production scheduling• Assess suitability of new/proposed methods for routine QC application and investigate opportunities for QC improvements (R&D)• Coordinate the stability study program, including sample procurement, testing, protocol/report writing and approval, database management, inventory control, and statistical projections• Review log books and manage data verification process.• Manage specification review process• Write, review, and approve out-of-specification (OOS) and out-of-trend (OOT) investigations & taking corrective action and preventative action (CAPA) • Manage the laboratory equipment calibration and qualification program. Maintain laboratory equipment in proper working order and adhere to maintenance and calibration schedules• Develop and implement laboratory documents (SOPs, Specifications, Protocols, Reports)• Oversee staff training to ensure proper laboratory operations and cGMP compliance• Determine department metrics and monitor lab performance; present information in management review meetings• Ensure laboratory cGMP compliance with FDA and other relevant regulations

• Executes testings of all raw materials and finished food products according to defined procedures• Ensured QC information and documentation is properly archived• Ensuring that all activities are performed according to the SOP's, as well as national and local regulations • Performed qualitative and quantitative analysis of water and fat soluble vitamins using Shimatsu HPLC, • Quantification of proteins using Leco FP-580 Protein/Nitrogen determinator• Maintenance and trouble shooting of Agilent and Shimatsu HPLC system and Leco FP-580 protein analyzer• Performed Identity tests of row materials using Infra red (IR) spectroscopy and other chemical tests• Performed vitamin and protein analysis of finished products (food supplements) for product release• Participates in investigations of laboratory deviations and OOS results• Prepared and evaluated SOPs for various analytical methods • Recording, interpreting and presenting results to senior as well as junior colleagues

• Developed and validated two RP-HPLC methods for spontaneous analysis of 11 Water soluble vitamins• General maintenance and trouble shooting of Shimatsu HPLC system and Leco FP-580 protein analyzer• Authored and reviewed SOPs of various analytical experiments (HPLC, IR, Protein analyzer, IR, PH meter etc.) • leading QC process improvement projects and ensuring lab compliance with FDA and other regulatory standards• Recording, interpreting and presenting results to senior as well as junior colleagues• Performed Identity tests of row materials using Infra red (IR) spectroscopy and other chemical tests

- Manage the planning, execution and completion of projects that involve: synthesis, purification, characterization as well as structural and bio physical studies of synthesized compounds - Performed large scale peptide synthesis using solid phase peptide synthesis technique - Designed and synthesized novel peptidyl-oligonuleotide conjugates (PCN) in large quantities - Purified, isolated and characterized synthesized peptides, oligonucleotides and conjugates using full scope of analytical techniques (HPLC, NMR and UV-visible)- Developed HPLC purification methods for peptides, oligonucleotides and conjugates- Performed qualitative 3D structures analysis of the synthesized conjugates using high-field 1D (1H,13C 31P) and 2D (COSY, TOCSY, NOESY & ROESY) NMR spectroscopy - Performed PCN:RNA binding experiments using UV-Visible and fluorescence based experiments- Maintaining general laboratory safety including preparing and evaluating SOPs - Ordering consumables and other chemicals and follow-up of orders with suppliers- Regular maintenance of laboratory equipments including: Rota-evaporator, HPLC, UV-visible, Fluorescence and other equipments- Provided technical support of the NMR spectrometers (300 MHz & 400 MHz Bruker) including: (i) NMR magnet fill with the liquid nitrogen (weekly) and helium (4 monthly) and (ii) Delivery and handling of cryogenic liquids (certified)- Mentored undergraduates research projects of two 4th year students and supervised their thesis development; - Provided guidance and assistance to 150 first year and 60 second year pharmacy students during their medicinal chemistry practical; - Assessed practical reports submitted by students according to guidelines set by the university- Graded and submitted practical reports to respective lecturers in charge of the practical courses and provided feedback to students

- Assisted Professor Ken Douglas in multi-step synthesis of fluorescent Ca2+ indicators- Impurity identification, isolation, re-crystallization and characterization of synthesized compounds- characterization of intermediates using a full scope of analytical techniques- Communicated results in group meetings- maintained general laboratory safety (including waste management) and prepared SOPs- Ordering consumables and other chemicals for the group and follow-up of orders with suppliers- Regular maintenance of laboratory equipments including Rota-evaporator, HPLC, Freeze drier, fridge’s and freezers etc.

- Worked in small molecule antimalarial drug discovery process (lead discovery and optimization)- Performed parallel synthesis medicinal chemistry to incorporate important antimalarial drug fragments into a privileged natural product scaffold (totarol) with inherent antimalaria activity - Investigated numerous reactions including hydrogenation, nucleophilic aromatic substitutions, C-C, C-N and C-O couplings reactions to incorporate various functionalities- Synthesized libraries of Mannich base, β-amino alcohol and semicarbazone derivatives of totarol- Impurity identification, isolation, re-crystallization and characterization of synthesized compounds- characterization of intermediates using a full scope of analytical techniques- Performed SAR studies of the synthesized compounds using analogue compounds- Prepared and submited final compounds for biological testing - Evaluated antiplasmodial activities of the synthesized compounds against Chlorquine sensitive and resistant strains of the parasite and interpreted their results- Presented research findings at scientific meetings including GORDON REASERCH CONFERENCE, Queens College, Oxford, UK - Provided guidance (demonstrator) to over 90 first year students during their organic chemistry practical - Graded and submitted practical reports to respective lecturers in charge of the practical courses and provided feedback to students

- Examined the phenolic contents (phenolic acids and flavonoids) of Roodeberg and Cathedral cellar wines of South Africa- Performed qualitative and quantitative analysis of the phenolic fractions using RP-HPLC - Prepared wine samples for HPLC purification by solid phase extraction technique using styrene divinyl benzene (SDVB) SPE cartridge- Presented and defended the research project at departmental meeting - Performed HPLC trouble shooting (Agilent model)