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Extensive expertise in the development and interpretation of biophysical assays to quantitate molecular interactions. Developed a nanoparticle-based bioassay for label- and power-free detection of membrane protein-ligand interactions in primary neuronal cells and membrane-anchored species. Built and modified a backscattering interferometry (BSI) instrument for use in the Finn lab, with de-novo engineered, automated, high-throughput capability. Adapted BSI for efficient, specific evaluation of molecular interactions in both simple and complex systems. Coordinated multiple internal and external efforts (CRO) to establish novel methods for small molecule (RNA, protein and and PROTAC) discovery and validation efforts.
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Business Development ManagerOpenbench Aug 2024 - PresentSan Francisco, Ca, Us -
Senior ScientistHexagon Bio Nov 2022 - Oct 2023Menlo Park, California, Us• Responsible for arrangement of biophysics group with both internal and external biophysics capabilities.• Establishment and coordination of CRO efforts worldwide to expand internal bandwidth in both biophysics and protein sciences. Organizations collaborated with include: NovAlix, Wuxi, Biortus, Viva Biotech, Enzymlogic, Pelago, Selvita, and Biognosys. • Enabling orthogonal biophysical validation and discovery efforts for novel fungal metabolite-target pairs; provide critical positive and negative confirmation to enable or terminate programs as needed. -
Senior ScientistWeatherwax Biotechnologies May 2022 - Sep 2022San Francisco, Ca, Ca• Development of internal platform to observe induced-proximity therapeutics.• Mentorship of junior scientists. -
ScientistTakeda Apr 2019 - May 2022Tokyo, Jp• Biophysical investigation of molecular interactions in disease pathogenesis and early hit-finding. Extensive use of novel and established high-throughput biophysical methods (SPR, SEC-ASMS, Native-Mass Spec, Fluorescence, Thermal Shift, Microscale Thermophoresis) • Coordination of international CRO efforts to expand internal bandwidth and develop internal expertise using a variety of techniques. Organizations collaborated with include: NovAlix, Wuxi, Biortus, Evotec, Admera, Specs, Exscientia, Lexogen, BioSpring, Viva Biotech, Enzymlogic, Acrobiosystems, Griffith University, Axcelead, Pelago, Selvita, Charles River, and others. • Responsible for setting up internal and external RNA biophysics efforts.• Assisted in developing methods for PROTAC discovery efforts.• Aided internal education development at Takdea; created the first (now ongoing) intern research presentation conference at Takeda California, and the first virtual session during the COVID-19 pandemic. -
Research ScientistGeorgia Institute Of Technology Jun 2014 - Apr 2019Atlanta, Georgia , Us• Investigation of immunology and disease pathogenesis using novel and established high-throughput assay methods. • Evaluated the molecular basis of Crohn’s disease (gut microbiome carbohydrate motifs), analysis of therapeutic compounds for Cystic Fibrosis (coordinated structural, binding, and functional receptor studies), screening of synthesized parasite (Leishmania) mono- and polymeric carbohydrate antigens, screening of HIV therapeutic small molecules and localized surface plasmon resonance (LSPR) studies for single molecule measurements.• De novo automation and refinement of novel analytical techniques (BSI), creation of new analytical methods involving nanoplasmonic signal enhancement and label-free protein detection in whole-cell systems. • Responsible for managing both internal and external collaborations as well as budgeting and timelines for milestones. • Mentoring and supervision of direct reports/students as well as colleagues. -
Postdoctoral FellowGeorgia Institute Of Technology Feb 2013 - May 2014Atlanta, Georgia , Us• Establishing a program to investigate novel applications of label-free assay technology, primarily focused on integration of BSI with established assay methods. • Responsible for setup of new laboratory infrastructure as well as mentoring/supervision of undergraduate researchers.• Implemented a program of instruction in optical methods and microscopy for the Finn Lab, taught as an informal, graduate level course. -
ConsultantSynamem Corporation Jan 2007 - Jan 2014• Development of HTS membrane-based assay systems.• Key in successfully transferring a membrane-based HTS assay from a technical academic lab to an external business partner.• Responsible for troubleshooting, evaluating and developing milestones, and creation of documentation as well as budget allocation for start-up experiments.
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Postdoctoral ResearcherThe Scripps Research Institute 2008 - 2013La Jolla, California, Us• Application of lipid bilayer membrane technology to biochemical and instrumental systems.• Integration of label-free detection methods with novel protein nanoparticle systems. -
Visiting ScholarVanderbilt University 2008 - 2012Nashville, Tennessee, Us• External development of label-free molecular detection technology (BSI). -
Research Technician IiaBerkeley Lab Jan 2001 - Jan 2003Berkeley, Ca, Us• Conducted independent research in membrane and colloid physics and physical chemistry.• Responsible for all IT-related tasks within parent research laboratory
Michael Baksh Skills
Michael Baksh Education Details
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Santa Clara University Leavey School Of BusinessExecutive Mba -
University Of California, BerkeleyBiophysics -
University Of California, BerkeleyMolecular And Cell Biology; Immunology Emphasis
Frequently Asked Questions about Michael Baksh
What company does Michael Baksh work for?
Michael Baksh works for Openbench
What is Michael Baksh's role at the current company?
Michael Baksh's current role is Biophysics | Success-Driven Drug Discovery | MBA Candidate.
What is Michael Baksh's email address?
Michael Baksh's email address is mm****@****ail.com
What schools did Michael Baksh attend?
Michael Baksh attended Santa Clara University Leavey School Of Business, University Of California, Berkeley, University Of California, Berkeley.
What skills is Michael Baksh known for?
Michael Baksh has skills like Microscopy, Cell Culture, Biophysics, Protein Chemistry, Nanoparticles, Assay Development, Fluorescence Microscopy, Biochemistry, Matlab, Mass Spectrometry, Protein Purification, Labview.
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