Michael Katz Email and Phone Number
Innovative structural biologist studying viral infection mechanisms with >5 years of industry experience. My MSc/PhD research (2019-2024) focused on the Lassa virus and elucidating how this lethal pathogenenters and later hijacks human cells. At the Weizmann Institute of Science, I solved the structure of thefull-length Lassa virus spike complex (along with its facilitatory enzyme) and determined the mechanism of receptor recognition (Katz et al., 2022, Nature). Outside of academia, I have worked at 3 biotechnology companies - primarily in Research & Development (R&D) and Chemistry, Manufacturing & Controls (CMC), for the characterization and purification of novel biologics. While living in the US, I developed biofuel production methods for several US government-funded projects. In the Israeli biotech sector, I designed analytical methods for a (now FDA-approved) third-generation Hepatitis B vaccine (PreHevbrio). Additionally, I optimized the downstream purification steps and carried out a stability study for bacteriophage formulations. I am currently looking for new opportunities in companies carrying out drug design and protein analysis. Highly experienced in: • protein purification • cryo-EM • crystallography • antibody design • assay development for eukaryotic cell lines • pseudovirus production • molecular cloning • HPLC • ELISA • cGMP regulations • SOP generation
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Phd Candidate At The Weizmann Institute Of ScienceWeizmann Institute Of Science Apr 2020 - PresentReẖOvot, Central, IsraelMy MSc/PhD research focuses on elucidating the infection mechanisms of pathogenic arenaviruses, such as the Lassa virus.Highly experienced with: single particle analysis cryo-electron microscopy (SPA cryo-EM), protein crystallography, membrane protein purification, pseudovirus generation, FACS, protein-protein interaction analysis (Octet, Biacore), eukaryotic cell culture (HEK293T/F, HAP1), ELISA, TFF buffer exchange, affinity chromatography, HPLC, genetic engineering. -
Msc CandidateWeizmann Institute Of Science Jan 2019 - Mar 2020Rehovot Area, Israel
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ResearcherWeizmann Institute Of Science Aug 2018 - Dec 2018Rehovot Area, Israel
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ScientistBiomx Ltd Aug 2017 - Aug 2018Rehovot Area, Israel- Designed & carried out a downstream processing study for a potential bacteriophage drug substance (DS).- Optimized free-DNA & endotoxin removal process for scaling up the purification of a phage lysate.- Generated hydrogels for a potential phage drug product (DP) formulations and conducted stability studies. -
R&D ResearcherScivac Ltd. Mar 2015 - Aug 2017Rehovot, Israel- Developed and validated analytical techniques, such as ELISA and chromatographic methods, to characterize their vaccine candidate (PreHevBrio) and quantify trace impurities.- Designed analytical methods to characterize biotherapeutics for third party CMC projects. - Carried out cGMP formulation & filling of Phase I-II drug substance (DS) in clean room facilities. -
Biochemical Engineer - InternScivac Ltd. Sep 2014 - Feb 2015Rehovot, Israel- Supported upstream cGMP operation/monitoring of bioreactors to produce vaccine (VLP displaying HBsAg, secreted from CHO cell culture).- Aided research on the development of analytical techniques (primarily HPLC & SDS-PAGE) and a stability & activity study in the R&D division for a potential drug product.
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Chemical EngineerLogos Technologies, Inc. Jun 2012 - Nov 2013Ashburn, Va & Visalia, CaAshburn, VA:- Developed a system for the generation of bacterial glycolipids (rhamnolipids, now marketed as NatSurFact, acquired by Stepan Company); investigated downstream purification methods. - Completed 1 L (and assisted with 30 L) aerobic fermentations for bioproduct generation.- Optimized bacterial growth conditions for a novel bioreactor system to produce biofuel using CO2/H2 from water electrolysis. Project was funded by ARPA-E and was carried out in collaboration with the University of California, Berkeley, Joint BioEnergy Institute.- Completed laboratory work on alkaline pretreatment for Phase II of DARPA BioJet Program to optimize the simultaneous saccharification and delignification of cellulosic material. Data was compiled for Terrabon Inc. for their MixAlco process. -Completed feasibility analyses and market studies for the isolation of co-products during biofuel production. Visalia, CA: - Conducted feedstock detoxification research at Edeniq’s facility (in Visalia, CA) to improve the productivity of their proprietary xylose-consuming yeast strain. - Completed laboratory work to support plant operations (cell counts, HPLC, GC, and lab-scale saccharification).- Assisted with process operations work during the plant's 1,000-hour run. -
Chemical Engineering InternLogos Technologies, Inc. May 2011 - May 2012Ashburn, VaFocused primarily on the process design of Lipid Fermentation Process (LFP) to produce a renewable source of J-8 fuel from switchgrass and wood pulp. Project with sponsored through Phase II of the DARPA BioJet Program. I helped design a process which efficiently grows lipids via fermentation and isolates through solvent extraction. Process was scaled up to production of 8 L and further developments were proposed to increase revenue by use of co-products, such as refining of phosphatidylcholine.Worked on the Mixed Alcohol Process (MAOP) in conjunction with Terrabon Inc. by completing an overall process flow diagram for the system and comparing two possible methods for the upgrading of the ketones to hydrocarbons.
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Summer InternWashington Suburban Sanitary Commission Jun 2010 - Aug 2010Laurel, Md
Michael Katz Education Details
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Structural Biology
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Structural Biology
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Chemical And Biochemical Engineering -
Chemical Engineering, Concentration In Biochemical Engineering & Biotechnology.
Frequently Asked Questions about Michael Katz
What company does Michael Katz work for?
Michael Katz works for Weizmann Institute Of Science
What is Michael Katz's role at the current company?
Michael Katz's current role is Structural Biologist at the Weizmann Institute of Science.
What schools did Michael Katz attend?
Michael Katz attended Weizmann Institute Of Science, Weizmann Institute Of Science, University Of California, Irvine, University Of Virginia.
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Michael Katz
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Michael Katz
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Michael Katz
Coos Bay, Or2hotmail.com, sharp.com -
Michael Katz
New York, Ny5gmail.com, mparticle.com, mparticle.com, interclick.com, intel.com10 +164637XXXXX
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