Extensive background in developing and executing multi-step organic syntheses of small molecule targets. Able to work independently at researching chemistry literature to design potential synthetic routes to desired target molecules. Capable of scaling up final compounds and common intermediates to 10-100gm quantities. Proficient at maintaining detailed lab notebook of all experiments and organized characterization data. Skills: NMR, MS, HPLC, ChemDraw, PowerPoint.

Collaborated with a Ph.D. supervisor in drug discovery to develop new leads and SAR supporting various in-house projects. Researched chemistry literature to design synthetic routes to target compounds. Completed multi-step syntheses of target compounds for biological testing. Characterized isolated compounds via NMR, MS, HLPC, CHN. Maintained detailed lab notebook of all experiments with organized binders of experimental data. Scaled up promising compounds to 10+ gm quantities for efficacy and toxicity studies. Reviewed patent literature to determine possible infringement of proposed synthetic targets. Regularly presented research at project team meetings and department off-site seminars.Specific projects: Contributed to the discovery and development of GDC-0449 (Vismodegib), a Hedgehog signaling pathway inhibitor for the treatment of basal cell carcinoma. Developed SAR around lead compound inhibitors of Factor VIIa for the treatment of deep vein thrombosis.

Completed multi-step syntheses of organic heterocyclic compounds for biological testing researching sorbitol dehydrogenase inhibitors and angiotension II antagonists. Characterized target and intermediate compounds via NRM, MS, CHN. Separated racemic mixtures using lipase enzymes and established enantiomeric purity by NMR of Mosher’s esters. Developed a synthetic route that allowed a large number of analogs to be prepared from a common intermediate which was prepared in 100 gm quantities. Maintained detailed lab notebook of all experiments and spectroscopic data.