*Antigen characterization team lead, recruited and mentored multiple PhD and MS scientists in a matrix environment*Scientific focus on cell-based assays and protein analytics to support multiple antigen and antibody optimization screens for in vivo candidate selection for multiple programs across the IDR preclinical portfolio*Designed and delivered a complete integrated “walk-away” automated system for cell and protein assays - capability to characterize entire mRNA pipeline and… Show more *Antigen characterization team lead, recruited and mentored multiple PhD and MS scientists in a matrix environment*Scientific focus on cell-based assays and protein analytics to support multiple antigen and antibody optimization screens for in vivo candidate selection for multiple programs across the IDR preclinical portfolio*Designed and delivered a complete integrated “walk-away” automated system for cell and protein assays - capability to characterize entire mRNA pipeline and expanding DNA pipeline (budget ~$1.5M)*Collaborate with internal digital and research teams and external vendor to design end-to-end database for sequence registration and experimental in vitro and in vivo data*Member of multiple viral and bacterial pre-clinical program teams advising on antigen design and characterization, resource coordination to achieve program goals*Collaborate cross-functionally with biological and mRNA science teams to advise on design and experimental strategy for mRNA platform discovery projects*Collaborate with formulation and technical development teams to provide data to support regulatory filings Show less

*Therapeutic project team scientist focused on autophagy, innate immunity and inflammatory bowel disease (ulcerative colitis and Crohn’s disease)*Established mechanisms of action for multiple protein protective and risk variants*Team lead for multiple high-throughput screens and hit validation activities*Collaborated with academic, industry and CRO partners to achieve and accelerate project goals and timelines*Managed research associates and protein production & characterization… Show more *Therapeutic project team scientist focused on autophagy, innate immunity and inflammatory bowel disease (ulcerative colitis and Crohn’s disease)*Established mechanisms of action for multiple protein protective and risk variants*Team lead for multiple high-throughput screens and hit validation activities*Collaborated with academic, industry and CRO partners to achieve and accelerate project goals and timelines*Managed research associates and protein production & characterization infrastructure (budget ~$0.5M)*Developed critical reagents and assay system to enable protein degrader strategy for key “undruggable” target*NMR fragment screening to determine ligandability of intrinsically disordered protein Show less

*Structural biology (NMR) projects focused on viral mRNA regulation of host transcription and translation mechanisms*Significant contributions to grants, publications, international conference presentations*Assisted faculty with laboratory infrastructure, training graduate and undergraduate students, academic collaborations; served as teaching assistant to freshman chemistry courses*Expert in maintenance and operation of high-field NMR spectrometer and computational… Show more *Structural biology (NMR) projects focused on viral mRNA regulation of host transcription and translation mechanisms*Significant contributions to grants, publications, international conference presentations*Assisted faculty with laboratory infrastructure, training graduate and undergraduate students, academic collaborations; served as teaching assistant to freshman chemistry courses*Expert in maintenance and operation of high-field NMR spectrometer and computational resources*Collaborated to elucidate binding mechanism of evolved mini-proteins to Ras oncoprotein Show less