Michael Feldkamp Email & Phone Number

Philadelphia, Pa, Us

Raritan, New Jersey, Us

• Serve as a protein biochemist in antigen design group within antibody discovery, a fast-paced R&D environment developing biological therapeutics• Serve as JBio team leader for a CAR-T program targeting multiple myeloma• Leverage protein biochemistry and purification technologies to support early development efforts to efficiently transition lead molecules from research to downstream process development• Manage and provide technical support regarding strategy and implementation of purification initiatives, areas of focus include, but are not limited to, purification and biochemical characterization of monoclonal antibodies and alternative scaffold proteins for research and early development studies• Act as a key scientific liaison between research and development teams• Manage CRO collaborations for outsourcing of cell engineering and protein purification work• Maintain accurate electronic laboratory notebooks and other records. Write technical reports, summaries, protocols, and manuscripts

Nashville, Tennessee, Us

• Engineered RPA70N mutant proteins to enable crystallization and determined over 50 crystal structures of RPA70N in complex with small molecules• Utilized fragment based small molecule screening to discover inhibitors of RPA70N and RPA32C domains of Replication Protein A (RPA) by NMR• Quantified binding affinity of peptides and inhibitors for RPA domains via ITC and NMR• Developed an in situ proteolysis method monitored by 2D NMR for RPA32C construct optimization and determined the first crystal structure of RPA32C

Iowa City, Iowa, Us

• Cloned, expressed, purified CaM mutants and determined their purity via HPLC and Mass Spec• Performed fluorescence based titrations to monitor changes in the Ca2+-binding affinity of the protein Calmodulin (CaM) in the presence of peptides or the drug Stelazine• Determined X-ray crystal structure of the C-domain of Ca2+-saturated CaM in complex with the drug Stelazine and the solution NMR structure of calcium free CaM in complex with a peptide derived from the voltage dependent sodium channel• Performed computational docking studies of Stelazine to CaM

Chicago, Il, Us

• Utilized phage display to identify human growth hormone (hGH) and human growth hormone receptor (hGHR) mutants that displayed increased binding affinity• Expressed and purified hGH and hGHR for binding and crystallization studies• Determined binding affinities of hGH for hGHR mutants via SPR• Responsible for purchasing laboratory chemicals and forecasting future laboratory needs, performed equipment maintenance.

• Monitored bromine level in cooling tower to minimize biofouling• Monitored yeast concentrations at the start of the fermentation process while monitoring daily fermentor pH and sugar concentrations in 12-6200 gallon fermentors.• Inspected packaged product to ensure quality standards• Assisted in pilot run of a new beer

Phd, Biochemistry

Bachelor Of Science (Bs), Biology, Chemistry