Michael Leininger Email and Phone Number
Michael Leininger work email
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Michael Leininger personal email
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Highly motivated and innovative cell and molecular biologist, with a track record of success and project impact in areas of Genomics, Investigative toxicology, Inflammation, Biomarkers, and Obesity/Diabetes drug discovery/translational pharmacology.* Advanced the understanding of Leptin in swine by completion of Masters Thesis from Purdue.* Establish molecular foundation for swine genomic research by creating cDNA clone libraries and a resulting EST sequence database from 33 pig tissues at Monsanto.* Developed hepatocyte spheroid three dimensional culture as more translatable model for predictive toxicology at Pharmacia.* Provided mechanistic insight and biomarker discovery to numerous projects at Pfizer through gene expression profiling, flow cytometry, lipid analysis, rad and non-rad immuno assays, primary cell culture and data/text mining.* Drove Pfizer’s most successful diabetes compound from screening to first in human proof of mechanism on a rapid timeline, through innovation, hard work and leadership.Perform very well in new areas of research, quickly gaining an understanding of the background biology and objectives, while easily picking up new techniques, often developing novel assays as well as assays from literature references.Specialties: - Utilization of human/primate cells, tissues, fluids and fecal matter for mechanism of action and biomarker identification- Taqman and Genechip Expression profiling and analyis.- Coordinating internal and external efforts for project design, execution and data delivery.- Developing the technical skills of others in the laboratory.- Text and data mining
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Senior Manager Of Technology DevelopmentOrion Genomics Oct 2011 - PresentSt Louis, Missouri, United StatesLead a team to develop new methodologies and optimize Standard Operating Procedures for implementation in South East Asia and St. Louis. -
Senior Scientist, Cardiovascular Metabolic And Endocrine Diseases, Groton CtPfizer Jun 2007 - Oct 2011- Biology Point Of Contact For Lead Diabetes Project: Established in vitro potency and selectivity of a lead inhibitor compound by developing primary and secondary glucose transport assays as primary point of contact for medicinal chemistry efforts. Submitted IND document sections to FDA as biology point of contact for lead inhibitor into First In Human studies.- Mechanism Of Action Group Lead: Generated testable hypotheses and publications regarding the mechanism of action of lipid modifying compound by coordinating diverse scientific expertise in the integration of genomics, lipomics, and phenotypic data across multiple species.- Senior Bench Scientist: Developed potential peripheral blood biomarker by establishing radioactive triglyceride synthesis assay in neutrophils and monocytes isolated from human blood samples. Ensured selectivity of lead compound against facilitative glucose transport by establishing radioactive glucose uptake assays in human THP-1 macrophages and primary human hepatocytes. Provided evidence of a direct effect of lipid modifying compound on triglyceride loading in ApoB captured VLDL particles secreted in human primary hepatocyte culture. Informed mechanism of action of lipid modifying compound by developing assays to measure various lipids and bacteria in monkey fecal samples. -
Senior Scientist, Discovery Biomarkers Group, Ann Arbor MiPfizer Aug 2005 - May 2007-Senior Scientist Discovery Biomarkers Group: Ensured that projects going forward had target and mechanism biomarkers to reduce attrition in the clinic. Established gene expression mechanism and efficacy biomarkers in human scalp punch biopsies. Cloned and characterized MC5R gene in hamsters to enable animal model for pre-clinical testing. - Thrombosis Project Core Team Member:Delivered translatable biomarker by establishing a novel platelet leukocyte complex flow cytometry assay. Wrote sections of Clinical Plan Document. -
Scientist, Expression Profiling Group, Ann Arbor MiPfizer Aug 2003 - Aug 2005- Scientist Expression Profiling: Enabled new target discovery for osteoarthritis (OA) by conducting Affymetrix Genechip analysis on RNA from human OA cartilage and synovium samples. Supported Inflammation TA for mechanism of action studies and model validation. - Fibromyalgia Working Group Lead: Organized and ran meetings; recorded and distributed minutes, and contributed to the design of expression profiling experiments. Processed tissues, performed experiments, mined data, and gave presentations to the working group. -
Senior ScientistPfizer Global Research & Development 1999 - Oct 2011
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Scientist, Investigative Toxicology, Kalamazoo MiPharmacia/Pfizer May 2002 - Aug 2003Scientist Toxicology: Developed hepatocyte spheroid model with toxicogenomic and metabolic properties of liver tissue enabling better prediction of in vivo toxicity. Used Genechip expression profiling to identify mechanisms and markers of toxicity. Provide expression profiling support to other project teams.
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Molecular BiologistMonsanto Sep 1999 - May 2002Molecular Biologist: Performed RNA extractions, and cDNA cloning in 33 pig tissues in swine for the creation of an EST database for numerous downstream application for the swine Genomics group. Enabled high through put genotyping of Dekalb swine by optimizing protocol for purification of genomic DNA from blood card punches. Made regular presentations to the genomics team. Designed and executed experiment to compare the gene expressions in 7 tissues of a lean vs. fat genetic pig line. -
Research Associate I, Swine Research Unit, Gray Summit MoPurnia Mills Research Center Mar 1999 - Aug 1999Research Associate I: Designed, directed and performed in vitro experiments investigating the hormonal and metabolic regulation of gene expression in porcine adipose tissue explants.
Michael Leininger Skills
Michael Leininger Education Details
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Animal Science -
Biology
Frequently Asked Questions about Michael Leininger
What company does Michael Leininger work for?
Michael Leininger works for Orion Genomics
What is Michael Leininger's role at the current company?
Michael Leininger's current role is Senior Manager of Technology Development.
What is Michael Leininger's email address?
Michael Leininger's email address is ml****@****ics.com
What schools did Michael Leininger attend?
Michael Leininger attended Purdue University, Purdue University.
What are some of Michael Leininger's interests?
Michael Leininger has interest in Kayakingrock Climbing, Kayaking Rock Climbing.
What skills is Michael Leininger known for?
Michael Leininger has skills like Biomarkers, Assay Development, Genomics, Drug Discovery, Cell, In Vitro, Flow Cytometry, Animal Models.
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Michael Leininger
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