Senior Manager Of Technology Development
CurrentLead a team to develop new methodologies and optimize Standard Operating Procedures for implementation in South East Asia and St. Louis.
Oct 2011 - Present
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Michael Leininger Email & Phone Number
Senior Manager of Technology Development
at
Orion Genomics
1 work email found
@oriongenomics.com
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Role
Senior Manager of Technology Development
Location
Greater St. Louis, United States, United States
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Who is Michael Leininger? Overview
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Michael Leininger is listed as Senior Manager of Technology Development at Orion Genomics, a company with 15 employees, based in Greater St. Louis, United States, United States. AeroLeads shows a work email signal at oriongenomics.com and a matched LinkedIn profile for Michael Leininger.
Michael Leininger previously worked as Senior Scientist, Cardiovascular Metabolic and Endocrine Diseases, Groton CT at Pfizer and Senior Scientist, Discovery Biomarkers Group, Ann Arbor MI at Pfizer. Michael Leininger holds Master Of Science, Animal Science from Purdue University.
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{first_initial}{last}@oriongenomics.com
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Profile bio
About Michael Leininger
Highly motivated and innovative cell and molecular biologist, with a track record of success and project impact in areas of Genomics, Investigative toxicology, Inflammation, Biomarkers, and Obesity/Diabetes drug discovery/translational pharmacology.* Advanced the understanding of Leptin in swine by completion of Masters Thesis from Purdue.* Establish molecular foundation for swine genomic research by creating cDNA clone libraries and a resulting EST sequence database from 33 pig tissues at Monsanto.* Developed hepatocyte spheroid three dimensional culture as more translatable model for predictive toxicology at Pharmacia.* Provided mechanistic insight and biomarker discovery to numerous projects at Pfizer through gene expression profiling, flow cytometry, lipid analysis, rad and non-rad immuno assays, primary cell culture and data/text mining.* Drove Pfizer’s most successful diabetes compound from screening to first in human proof of mechanism on a rapid timeline, through innovation, hard work and leadership.Perform very well in new areas of research, quickly gaining an understanding of the background biology and objectives, while easily picking up new techniques, often developing novel assays as well as assays from literature references.Specialties: - Utilization of human/primate cells, tissues, fluids and fecal matter for mechanism of action and biomarker identification- Taqman and Genechip Expression profiling and analyis.- Coordinating internal and external efforts for project design, execution and data delivery.- Developing the technical skills of others in the laboratory.- Text and data mining
Listed skills include Biomarkers, Assay Development, Genomics, Drug Discovery, and 4 others.
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8 roles · 27 years
Michael Leininger work experience
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Senior Scientist, Cardiovascular Metabolic And Endocrine Diseases, Groton Ct
- Biology Point Of Contact For Lead Diabetes Project: Established in vitro potency and selectivity of a lead inhibitor compound by developing primary and secondary glucose transport assays as primary point of contact for medicinal chemistry efforts. Submitted IND document sections to FDA as biology point of contact for lead inhibitor into First In Human.
Jun 2007 - Oct 2011
Senior Scientist, Discovery Biomarkers Group, Ann Arbor Mi
-Senior Scientist Discovery Biomarkers Group: Ensured that projects going forward had target and mechanism biomarkers to reduce attrition in the clinic. Established gene expression mechanism and efficacy biomarkers in human scalp punch biopsies. Cloned and characterized MC5R gene in hamsters to enable animal model for pre-clinical testing. - Thrombosis.
Aug 2005 - May 2007
Scientist, Expression Profiling Group, Ann Arbor Mi
- Scientist Expression Profiling: Enabled new target discovery for osteoarthritis (OA) by conducting Affymetrix Genechip analysis on RNA from human OA cartilage and synovium samples. Supported Inflammation TA for mechanism of action studies and model validation. - Fibromyalgia Working Group Lead: Organized and ran meetings; recorded and distributed.
Aug 2003 - Aug 2005
Senior Scientist
Pfizer Global Research & Development
1999 - Oct 2011
Scientist, Investigative Toxicology, Kalamazoo Mi
Pharmacia/Pfizer
Scientist Toxicology: Developed hepatocyte spheroid model with toxicogenomic and metabolic properties of liver tissue enabling better prediction of in vivo toxicity. Used Genechip expression profiling to identify mechanisms and markers of toxicity. Provide expression profiling support to other project teams.
May 2002 - Aug 2003
Molecular Biologist
Molecular Biologist: Performed RNA extractions, and cDNA cloning in 33 pig tissues in swine for the creation of an EST database for numerous downstream application for the swine Genomics group. Enabled high through put genotyping of Dekalb swine by optimizing protocol for purification of genomic DNA from blood card punches. Made regular presentations to.
Sep 1999 - May 2002
Research Associate I, Swine Research Unit, Gray Summit Mo
Purnia Mills Research Center
Research Associate I: Designed, directed and performed in vitro experiments investigating the hormonal and metabolic regulation of gene expression in porcine adipose tissue explants.
Mar 1999 - Aug 1999
2 education records
Michael Leininger education
Master Of Science, Animal Science
Bachelor Of Science Degree, Biology
FAQ
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What company does Michael Leininger work for?
Michael Leininger works for Orion Genomics.
What is Michael Leininger's role at Orion Genomics?
Michael Leininger is listed as Senior Manager of Technology Development at Orion Genomics.
What is Michael Leininger's email address?
AeroLeads has found 1 work email signal at @oriongenomics.com for Michael Leininger at Orion Genomics.
Where is Michael Leininger based?
Michael Leininger is based in Greater St. Louis, United States, United States while working with Orion Genomics.
What companies has Michael Leininger worked for?
Michael Leininger has worked for Orion Genomics, Pfizer, Pfizer Global Research & Development, Pharmacia/Pfizer, and Monsanto.
How can I contact Michael Leininger?
You can use AeroLeads to view verified contact signals for Michael Leininger at Orion Genomics, including work email, phone, and LinkedIn data when available.
What schools did Michael Leininger attend?
Michael Leininger holds Master Of Science, Animal Science from Purdue University.
What skills is Michael Leininger known for?
Michael Leininger is listed with skills including Biomarkers, Assay Development, Genomics, Drug Discovery, Cell, In Vitro, Flow Cytometry, and Animal Models.
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