Michael Leininger

Michael Leininger Email and Phone Number

Senior Manager of Technology Development @ Orion Genomics
Michael Leininger's Location
Greater St. Louis, United States
Michael Leininger's Contact Details

Michael Leininger work email

Michael Leininger personal email

About Michael Leininger

Highly motivated and innovative cell and molecular biologist, with a track record of success and project impact in areas of Genomics, Investigative toxicology, Inflammation, Biomarkers, and Obesity/Diabetes drug discovery/translational pharmacology.* Advanced the understanding of Leptin in swine by completion of Masters Thesis from Purdue.* Establish molecular foundation for swine genomic research by creating cDNA clone libraries and a resulting EST sequence database from 33 pig tissues at Monsanto.* Developed hepatocyte spheroid three dimensional culture as more translatable model for predictive toxicology at Pharmacia.* Provided mechanistic insight and biomarker discovery to numerous projects at Pfizer through gene expression profiling, flow cytometry, lipid analysis, rad and non-rad immuno assays, primary cell culture and data/text mining.* Drove Pfizer’s most successful diabetes compound from screening to first in human proof of mechanism on a rapid timeline, through innovation, hard work and leadership.Perform very well in new areas of research, quickly gaining an understanding of the background biology and objectives, while easily picking up new techniques, often developing novel assays as well as assays from literature references.Specialties: - Utilization of human/primate cells, tissues, fluids and fecal matter for mechanism of action and biomarker identification- Taqman and Genechip Expression profiling and analyis.- Coordinating internal and external efforts for project design, execution and data delivery.- Developing the technical skills of others in the laboratory.- Text and data mining

Michael Leininger's Current Company Details
Orion Genomics

Orion Genomics

View
Senior Manager of Technology Development
Employees:
15
Michael Leininger Work Experience Details
  • Orion Genomics
    Senior Manager Of Technology Development
    Orion Genomics Oct 2011 - Present
    St Louis, Missouri, United States
    Lead a team to develop new methodologies and optimize Standard Operating Procedures for implementation in South East Asia and St. Louis.
  • Pfizer
    Senior Scientist, Cardiovascular Metabolic And Endocrine Diseases, Groton Ct
    Pfizer Jun 2007 - Oct 2011
    - Biology Point Of Contact For Lead Diabetes Project: Established in vitro potency and selectivity of a lead inhibitor compound by developing primary and secondary glucose transport assays as primary point of contact for medicinal chemistry efforts. Submitted IND document sections to FDA as biology point of contact for lead inhibitor into First In Human studies.- Mechanism Of Action Group Lead: Generated testable hypotheses and publications regarding the mechanism of action of lipid modifying compound by coordinating diverse scientific expertise in the integration of genomics, lipomics, and phenotypic data across multiple species.- Senior Bench Scientist: Developed potential peripheral blood biomarker by establishing radioactive triglyceride synthesis assay in neutrophils and monocytes isolated from human blood samples. Ensured selectivity of lead compound against facilitative glucose transport by establishing radioactive glucose uptake assays in human THP-1 macrophages and primary human hepatocytes. Provided evidence of a direct effect of lipid modifying compound on triglyceride loading in ApoB captured VLDL particles secreted in human primary hepatocyte culture. Informed mechanism of action of lipid modifying compound by developing assays to measure various lipids and bacteria in monkey fecal samples.
  • Pfizer
    Senior Scientist, Discovery Biomarkers Group, Ann Arbor Mi
    Pfizer Aug 2005 - May 2007
    -Senior Scientist Discovery Biomarkers Group: Ensured that projects going forward had target and mechanism biomarkers to reduce attrition in the clinic. Established gene expression mechanism and efficacy biomarkers in human scalp punch biopsies. Cloned and characterized MC5R gene in hamsters to enable animal model for pre-clinical testing. - Thrombosis Project Core Team Member:Delivered translatable biomarker by establishing a novel platelet leukocyte complex flow cytometry assay. Wrote sections of Clinical Plan Document.
  • Pfizer
    Scientist, Expression Profiling Group, Ann Arbor Mi
    Pfizer Aug 2003 - Aug 2005
    - Scientist Expression Profiling: Enabled new target discovery for osteoarthritis (OA) by conducting Affymetrix Genechip analysis on RNA from human OA cartilage and synovium samples. Supported Inflammation TA for mechanism of action studies and model validation. - Fibromyalgia Working Group Lead: Organized and ran meetings; recorded and distributed minutes, and contributed to the design of expression profiling experiments. Processed tissues, performed experiments, mined data, and gave presentations to the working group.
  • Pfizer Global Research & Development
    Senior Scientist
    Pfizer Global Research & Development 1999 - Oct 2011
  • Pharmacia/Pfizer
    Scientist, Investigative Toxicology, Kalamazoo Mi
    Pharmacia/Pfizer May 2002 - Aug 2003
    Scientist Toxicology: Developed hepatocyte spheroid model with toxicogenomic and metabolic properties of liver tissue enabling better prediction of in vivo toxicity. Used Genechip expression profiling to identify mechanisms and markers of toxicity. Provide expression profiling support to other project teams.
  • Monsanto
    Molecular Biologist
    Monsanto Sep 1999 - May 2002
    Molecular Biologist: Performed RNA extractions, and cDNA cloning in 33 pig tissues in swine for the creation of an EST database for numerous downstream application for the swine Genomics group. Enabled high through put genotyping of Dekalb swine by optimizing protocol for purification of genomic DNA from blood card punches. Made regular presentations to the genomics team. Designed and executed experiment to compare the gene expressions in 7 tissues of a lean vs. fat genetic pig line.
  • Purnia Mills Research Center
    Research Associate I, Swine Research Unit, Gray Summit Mo
    Purnia Mills Research Center Mar 1999 - Aug 1999
    Research Associate I: Designed, directed and performed in vitro experiments investigating the hormonal and metabolic regulation of gene expression in porcine adipose tissue explants.

Michael Leininger Skills

Biomarkers Assay Development Genomics Drug Discovery Cell In Vitro Flow Cytometry Animal Models

Michael Leininger Education Details

Frequently Asked Questions about Michael Leininger

What company does Michael Leininger work for?

Michael Leininger works for Orion Genomics

What is Michael Leininger's role at the current company?

Michael Leininger's current role is Senior Manager of Technology Development.

What is Michael Leininger's email address?

Michael Leininger's email address is ml****@****ics.com

What schools did Michael Leininger attend?

Michael Leininger attended Purdue University, Purdue University.

What are some of Michael Leininger's interests?

Michael Leininger has interest in Kayakingrock Climbing, Kayaking Rock Climbing.

What skills is Michael Leininger known for?

Michael Leininger has skills like Biomarkers, Assay Development, Genomics, Drug Discovery, Cell, In Vitro, Flow Cytometry, Animal Models.

Not the Michael Leininger you were looking for?

  • Michael Leininger

    Is Risk And Compliance Associate Manager At Astellas Pharma
    Arlington Heights, Il
    5
    cna.com, wowway.com, us.astellas.com, astellas.com, astellas.us

    4 +184734XXXXX

  • 3
    fuse.net, sksins.com, jenzabar.com
  • Michael Leininger

    Assistant Vice President - Underwriting Manager At The Cincinnati Specialty Underwriters Insurance Company
    Cincinnati Metropolitan Area
    4
    cinfin.com, nationwide.com, nationwide.com, nationwide.com
  • Michael Leininger

    Minneapolis, Mn
    1
    peoplenetonline.com

    2 +195290XXXXX

Free Chrome Extension

Find emails, phones & company data instantly

Find verified emails from LinkedIn profiles
Get direct phone numbers & mobile contacts
Access company data & employee information
Works directly on LinkedIn - no copy/paste needed
Get Chrome Extension - Free

Aero Online

Your AI prospecting assistant

Download 750 million emails and 100 million phone numbers

Access emails and phone numbers of over 750 million business users. Instantly download verified profiles using 20+ filters, including location, job title, company, function, and industry.