Michael Poss Email & Phone Number

Trenton, Nj, Us

Lawrence Township, Nj, Us

- Managed a chemistry group across two sites focused on the progression of linear and macrocyclic peptides as therapeutics, drug conjugates, and imaging agents.- Advanced three compounds into clinical development, two therapeutics and one PET agent.- Coordinated the development of new software to efficiently generate peptide sequences and structures, evaluate SAR, and propose new sequences combining productive mutations.- Led the adoption of new organizational processes to streamline the synthesis and purification of peptidic analogs for SAR optimization.- Directed the development of novel solid phase and solution phase chemistry to prepare and functionalize amino acids and advanced peptide intermediates.- Drove the implementation of new methodology and instrumentation to enable the large-scale synthesis of peptides and peptide intermediates.- Advanced the study of nanoparticles to improve peptide dissolution, cell permeability and oral bioavailability.- Managed several academic collaborations exploring topics such as peptide grafting, cell targeting, and the flash nanoprecipitation of peptides.- Managed numerous biotech collaborations exploring topics such as selection strategies to provide orally bioavailable peptides, and novel formulations to enhance peptide bioavailability.

Lawrence Township, Nj, Us

- Managed a Hits to Leads chemistry group focused on the progression of immunology and oncology early phase programs.- In total, many different early phase efforts were progressed to full phase programs that subsequently delivered clinical assets such as beclabuvir (HCV NS5B), deucravacitinib (TYK2), afimetoran (TLR7/8 antagonist), and BMS-986158 (BRD4 inhibitor).- Established novel hardware and software for large scale library synthesis (1K to 5K compounds).- Directed the synthesis, purification, and characterization of 45,000 millamolecular analogs over the period of one year.- Managed an external academic collaboration exploring the in-situ cell-based biosynthesis and testing of genetically engineered peptide analogs.- Chaired the committee that prioritized the allocation of macromolecular resources (CADD, Protein Sciences, NMR, and X-ray) across all programs at the BMS Lawrenceville site.- Chaired the committee that coordinated HTS screens and resources for immunology and oncology programs at the BMS Lawrenceville site.

Lawrence Township, Nj, Us

- Managed three Hits to Leads chemistry groups totaling ~40 chemists across different sites that concurrently prosecuted ~10 different early phase programs.- Co-chaired the exploratory and early phase operating committee at the Lawrenceville site providing review and prioritization of immunology and oncology programs.- Chaired the committee that prioritized the allocation of macromolecular resources (CADD, Protein Sciences, NMR, and X-ray) across all programs at the BMS Lawrenceville site.- Advanced hit identification, validation, and optimization processes. Coordinated the establishment of significantly improved screening triage processes.- Advanced the definition of Program Readiness Criteria. Authored a corporate Program Readiness document that provided guidelines for programs to move from exploratory to early and full phases.

Lawrence Township, Nj, Us

- Managed three Hits to Leads chemistry groups totaling ~25 chemists that concurrently collaborated with ~10 ongoing early phase and full phase medicinal chemistry teams to prepare program analogs using a variety of automated solid phase, solution phase, or mixed solution/solid phase methodologies.- Directed a group of three computational chemists dedicated to developing database and computational methodology to support array synthesis and combinatorial chemistry. Oversaw the development of proprietary computational tools to triage hits from high throughput screening.- Served as the Chemistry Project Manager for the BMS/3DP ThermoFluor collaboration. Directed the screening and chemistry efforts of ~20 FTEs that prepared novel analogs for newly identified genomics targets.- Directed a biotransformation group of three scientists that prepared synthesis intermediates and metabolites using enzymatic processes.- Established the Fast Analog Synthesis Team (FAST), a group of synthetic chemists dedicated to the synthesis of arrays of focused program analogs.

Lawrence Township, Nj, Us

- Managed an integrated team consisting of four different groups working on large library synthesis, Hits to Leads chemistry, and computational design- Directed a large library synthesis group of eight chemists that designed and synthesized diverse and drug-like combinatorial libraries to enhance the compound screening collection. In collaboration with the high throughput screening group, advanced multiple successful focused screening campaigns utilizing target class directed combinatorial libraries- Directed two Hits to Leads chemistry groups totaling ~20 chemists that concurrently collaborated with ~10 ongoing full phase and early phase medicinal chemistry programs to advance SAR using a variety of automated solid phase, solution phase, or mixed solution/solid phase methodologies- Directed a group of three computational chemists dedicated to developing databases and computational methodology to support array synthesis and combinatorial chemistry. The team developed a proprietary combinatorial informatics system that was exchanged for genomics technology from Exelixis. Additional projects included the development of computational tools to virtually screen trillions of potential combinatorial compounds, computational tools to design multi-component combinatorial libraries optimized using genetic algorithms, and an interactive program to efficiently display and analyze HTS screening data- Initiated and co-supervised the BMS/IRORI NanoKan collaboration that led to the successful development and implementation of an automated synthesis system capable of the efficient preparation of 10-20K combinatorial libraries- Served as the Chemistry Project Manager for the BMS/3DP ThermoFluor collaboration. Directed the screening and chemistry efforts of ~20 FTEs that prepared novel analogs for newly identified genomics based anti-infective targets- Served as the Kinase Target Team co-chair. Organized focused screening efforts and assemblage of 10K kinase mini decks

Lawrence Township, Nj, Us

Lawrence Township, Nj, Us

- Supervised a combinatorial chemistry synthesis group of 16 chemists which concurrently collaborated with multiple ongoing full phase and early phase programs to prepare new analogs using a variety of automated solid phase, solution phase, or mixed solution/solid phase methodologies.- Identified three development candidates using combinatorial and automated array synthesis methodology, including lomitapide, a novel inhibitor of microsomal triglyceride transfer protein (MTP). Lomitapide was the first BMS clinical candidate to be prepared initially via robotics.- Advanced the development of novel solid phase chemistry methodology and linker technology.- Authored an ISIS based multi-form interface for use by ~1,200 scientists which provided the first integrated enterprise-wide informatics tool at BMS that combined chemical, biological, and high throughput screening data from different corporate Oracle databases.- Authored an ISIS based multi-form interface which integrated commercial reagent data, in-house reagent inventory, combinatorial synthesis reagent data, and combinatorial synthesis product data from commercial ISIS databases and corporate Oracle databases.- Authored an Excel based Synthesis Workbook for data handling during parallel and combinatorial synthesis which electronically integrated chemical synthesis information between corporate databases, local databases, Zymark robots, liquid handlers, mass specs, and HPLCs.- Authored an Excel based Ordering Workbook for automated purchasing of chemical reagents and laboratory supplies which provided a paperless path to secure needed materials.- Authored several Excel based Workbooks for automated data capture, data reduction, and database entry of biological assay results.

Lawrence Township, Nj, Us

- Developed new methodology for the synthesis of phosphonate diester prodrugs.- Developed novel phosphonate pro-drug analogs of squalene synthase inhibitors.

Lawrence Township, Nj, Us

- Developed improved chemical syntheses of lead drug candidates.- Developed an improved production scale synthesis of the anti-thrombotic agent ifetroban which reduced the length of the route from 16 steps to 7 steps.- Developed a novel production scale semi-synthesis of the anticancer agent paclitaxel from 10-desacetylbaccatin III.

Lawrence Township, Nj, Us

- Designed and synthesized angiotensin II receptor antagonists.- Identified and developed four different lead series.- Lead compound approved as a development candidate, advanced to investigational toxicology.- Developed new methodology for the synthesis of tetrazoles.

Lawrence Township, Nj, Us

- Designed and synthesized inhibitors of the aspartyl protease, renin.- Developed a novel sulfonamide protecting group.- Developed new methodology for the synthesis of amidines and guanidines.- Developed new methodology for the preparation of imidazolones.

Rahway, New Jersey, Us

- Modeled biologically active compounds interacting with proteins and enzymes.- Developed software applicable to the solution of medicinal chemistry problems.- Designed and synthesized potential therapeutic agents for the treatment of hypercholesterolemia.

Rochester, New York, Us

- Authored new code to better integrate in house hardware and software.

Doctor Of Philosophy - Phd, Organic Chemistry

Bachelor Of Science - Bs, Chemistry