Michael Van Gerven Email and Phone Number
Already from a very young age I knew that I wanted to become a scientist. During high school I discovered that I really like chemistry and biology and for that reason I decided that I would like to become a molecular biologist. However, to reach the university to become a scientist I had to climb a long way, because I started at the level of vmbo-tl. I was able to overcome these roadblocks by my great perseverance and motivation to work in a laboratory in the future. During my bachelor I became fascinated by molecular biology and developmental biology, especially the role of epigenetic and genetic mechanisms intrigued me. For that reason I decided to participate in the master programme Cancer, Stem Cells and Developmental Biology. During my masters I have acquired experience in a broad area of topics. I have worked with a plethora of molecular techniques and developed a lot of expertise in cell culture. I worked in a lab at the Hubrecht Institute and at the EMBL Heidelberg, where I had the opportunities to focus on a variety of distinct and interesting projects. Nothing is as fascinating and appealing to me as performing research. I really like the unpredictability of the work that comes with a great variability in the day-to-day tasks and gives room for my great creativity, which I also utilise by writing fantasy books. This creativity has aided me in the past to solve several problems that I stumbled upon in the lab. I really enjoy to work on projects in which the molecular topic of investigation can be related to higher order processes, such as to disease development or evolution. Particularly the role of genetic and epigenetic processes herein intrigues me. Additionally, I became fascinated by mitochondria, ageing, neurodevelopment and neurodevelopmental disorders. currently I am performing research into a specific gene (ATRX) that is frequently mutated in Neuroblastomas and attempt to identify how this gene is involved in cancer development. additionally I try to identify novel therapies for patients with this specific mutations, since currently only standard therapy is available.
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Postdoctoraal OnderzoekerLeiden University Medical Center Feb 2023 - PresentLeiden, Zuid-Holland, Nederland -
Phd CandidatePrinses Máxima Centrum Voor Kinderoncologie May 2018 - Oct 2022Utrecht En Omgeving, Nederland -
Assistant TeacherStudiekring Nov 2017 - Apr 2018Amersfoort
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Assistant TeacherLyceo Jan 2016 - Apr 2018Netherlands -
Research InternEmbl Feb 2017 - Aug 2017Heidelberg, Baden-Württemberg, GermanyThe European Molecular Biology Laboratory (EMBL) is one of the world’s leading research institutions, and Europe’s flagship laboratory for the life sciences. The research here is conducted by 1600 employees at 6 sites across Europe and divided into more then 80 independent research groups. In EMBL-Heidelberg I worked in the group of dr. Kyung-Min Noh, whose main focus is the role of chromatin in typical neurodevelopment and in developmental disorder. Here I worked on a gene that is highly associated with autism spectrum disorder and is indirectly involved in epigenetics through its histone-modifying binding partner. In this project I successfully re-introduced the complete and several patient-specific mutant forms of the gene in a homozygous and heterozygous knock-out (KO) mouse embryonic stem cell line. By qPCR I validated that introduction of the wild-type gene led to restoration of the most significant differentially expressed genes observed for the KO cell lines. Additionally, I determined the molecular aetiology of 6 patient mutations by western blot analysis and showed with immunopreciptation that there is an indication that the mutants might not be able to bind to the histone-modifying binding partner of our gene of interest. Altogether, I had a great time in the EMBL and had the pleasure to work and connect with many dedicated people. -
Research InternHubrecht Institute, Developmental Biology And Stem Cell Research Sep 2015 - Aug 2016UtrechtThe Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW) - situated on the campus of the Utrecht University - and with a focus on developmental and stem cell biology. The research here is conducted by 19 independent research groups that combined consist of a total of 220 employees. Here I worked in the group of prof. dr. Wouter de Laat, whose main focus is the role of the 3D structure of the nucleus on genome function and haplotyping with their own designed technique Targeted-Locus Amplification (TLA). In this group I had two project, one involved haplotyping of patients with beta-thalassemia, while the other consisted of performing optimisations for developing a new technique. For the first project I generated targeted haplotypes for two patients of the HBB locus, which is the region containing the patient mutations. In this manner I validated that haplotypes could be generated for this repetitive DNA region and therefore that the technique non-invasive prenatal diagnostics (NIPD) – developed by Wouter’s group – could potentially also be used for patients with beta-thalassemia. The second project is confidential, however I can tell that we had some promising results and that I learned a lot about bacterial cloning with electroporation. Additionally, I decided to improve the protocol for making electro-competent cells and resulted in a significant reduction of the time needed to create and validate the cells. Furthermore, the improvement I made also led to a higher electroporation efficiency. However, the most important thing that I learned here is that I really like to work in the lab. -
SalesmanJack & Jones Aug 2013 - May 2015Hilversum, Provincie Noord-Holland, NederlandJack&Jones is a franchise store that is part of Bestseller company and exclusively sells men's clothes. I had several responsibilities here, namely:• Helping costumers proactively• Handling transactions• Ensuring goods are well displayed and refilled• Keeping the shop tidy and well organisedI acquired several skills during this job:• Cooperating in a small team• Talking about many different subjects• Being proactive all the time (even though this could be a bit scary sometimes)I had a great time here together with my colleagues, in which we had to closely collaborate to reach the daily sales targets. A part of our collaboration included friendly competitions, in which we all individually tried to sell the most. Very often I won these competitions to my own surprise and even defeated the shop manager several times. Therefore, I learned that competition and cooperation can go hand in hand with each other, but only when collaboration is the main focus. -
MerchandiserHoogvliet Bv Dec 2011 - Jun 2013Hilversum, Provincie Noord-Holland, NederlandHoogvliet is one of the cheapest supermarkets in the Netherlands and has a total of 67 shops distributed across 4 out of the 12 provinces. Here I had several responsibilities, namely:• Re-stocking of shelves• Keeping the shop tidy and well organised• Helping customers• CleaningI acquired several skills during this job, namely:• Working as fast and efficient as possible• Cooperating with many people of different ages• To think commercially Here I had the great pleasure to work with a lot of interesting people, all with other personalities and ambitions. The most important think that I learned here was to minimize the time needed to perform all the work, by planning the work in advance.
Michael Van Gerven Education Details
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Master Of Science (Msc), Biomedical Sciences: Cancer, Stem Cells & Developmental Biolgy -
Biology
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Comenius CollegeAtheneum -
Comenius CollegeHavo
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Savornin LohmanVmbo-Tl
Frequently Asked Questions about Michael Van Gerven
What company does Michael Van Gerven work for?
Michael Van Gerven works for Leiden University Medical Center
What is Michael Van Gerven's role at the current company?
Michael Van Gerven's current role is Postdoctoral researcher at LUMC.
What schools did Michael Van Gerven attend?
Michael Van Gerven attended Utrecht University, Utrecht University, Comenius College, Comenius College, Savornin Lohman.
Who are Michael Van Gerven's colleagues?
Michael Van Gerven's colleagues are Rianne Dolmans, Wisse Van Der Laan, Simone Van De Pas, Ahmed Al Jaff, Martijn Van Putten, Tamara M., Tessa Van Henten, Md.
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Mike Van Gerven
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Michael Van Gerven
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