Michael Peel Email & Phone Number

Philadelphia, Pa, Us

San Diego, California, Us

- Foundational member, bioanalytical/research group lead- Key member in initiating, designing, and overseeing studies, both external and internal- Contributed to FDA INTERACT meeting application with data, writing, and strategy- Trained first wave of scientist hires at Capstan in assays I developed, and especially in how to work with targeted lipid nanoparticles (tLNPs)- For much of the first year of Capstan’s operation, served as the sole scientist, responsible for conceiving and carrying out all hands-on studies, leading to the rapid generation of several crucial proof of concept milestones- Worked within cross-functional groups to develop product pipelines and guide scientific strategy- Responsible for establishing SOPs, external collaborations, and tech transfers to establish a fully functional bioanalysis group at Capstan- Responsible for any research required to better understand the behavior and functionality of tLNPs, entailing the development and validation of necessary assays- Hired, trained, and managed a team of direct report scientists

Wilmington, Delaware, Us

- Design and execute in vivo and in vitro pre-clinical studies- Initiate and manage external collaborations with CROs and academic groups

Wilmington, Delaware, Us

-Coordinated and carried out studies of potential treatments for Graft vs. Host Disease using murine models- Established a combination of in vivo and in vitro models of cytokine release syndrome (CRS) to allow effective study of potential therapeutics in treating CRS.- Co-recipient of Incyte’s 2019 3 R’s award (Replacement, Reduction, Refinement) for being part of a small team that implemented use of transdermal sensors to monitor mouse kidney function in situ, obviating the need for continuous bleeds.

Wilmington, Delaware, Us

- Conducted studies using mouse models of skin inflammation to test potential therapeutics- Profiled a humanized mouse model of graft vs. host disease to determine the set of cell types engrafted- Assayed the effects of CAR-T cells and co-treatments in a mouse lymphoma model study- Performed studies both in mouse and cell culture models to test effects of therapeutics in cytokine release syndrome

Pa, Us

Lab: Stephen A. LiebhaberContinuation of projects investigating the regulation of cell types within the anterior pituitary

Pa, Us

Lab: Stephen A. LiebhaberProjects:-Design, construction, and validation of transgene constructs and expression vectors to generate novel transgenic mouse lines to support studies- Study of the establishment and maintenance of somatotrope and lactotrope cells within the anterior pituitary-RNA-seq and transcriptomic profiling of purified somatotrope and lactotrope cell populations- Identification and validation of novel transcription factors involved in regulation of anterior pituitary hormone genes- Single-cell RNA sequencing (Drop-seq) of whole mouse pituitary, profiling of cell populations

Pa, Us

Lab: Montserrat AngueraProject: Identification of novel isoforms of the long non-coding RNA Jpx in human induced pluripotent cells undergoing X chromosome inactivation

Pa, Us

Lab: Shelley BergerProject: Investigating the role of Brd4 in protamination of chromatin during spermatogenesis

Villanova, Pa, Us

Lab: Dennis D. WykoffProject: Investigating evolutionary/regulatory relationships between pathogenic and non-pathogenic species of yeast in the thiamine biosynthesis pathway.

Villanova, Pa, Us

Lab: Dennis D. WykoffProject: Identification of regulatory elements in the Pho1 promoter in Schizosaccharomyces Pombe involved in the phosphate starvation response

Doctor Of Philosophy - Phd, Genetics And Epigenetics

Bachelor Of Science - Bs, Biology, General