Michael Sowers Email & Phone Number

San Diego, CA, US

Marlborough, MA, US

- Designed and managed feasibility and validation activities for transfer of chemiluminescent assays to SpectraMax L microplate reader- Conducted investigations on raw and finished materials using FTIR, HPLC, UPLC, Capillary Gel Electrophoresis, and TOF LCMS supporting QC and Manufacturing- Participated in product trend evaluations assessing out-of-trend.

San Diego, California, US

- Established LCMS strategy for high throughput absolute quantitation of high value protein targets as part of Belharra proprietary probe screening- Devised statistical approaches to prioritize selective binding events observed in internal and external screens to be incorporated into Belharra data portals- Operated and maintained Thermo Altis QqQ.

New York, New York, US

- Operated and maintained Thermo Scientific Orbitrap Fusion Lumos and Eclipse LCMS systems- Worked to establish immunoprecipitation and LCMS methods for immunopeptidomic workflows supporting next generation immuno-oncology therapeutics- Performed top-down LCMS characterization of next generation antibodies supporting production and purification development

New York, New York, US

- Managed high-resolution qTOF, Triple Quad, and MALDI MS instruments and applications for Early Bioprocess Development and Cancer Vaccines & Immunotherapeutics- Developed quantitative method for measurement of host cell proteins and enveloped virus characterization supporting downstream purification development using Bruker Impact II qTOF LC-MS/MS.

New York, New York, US

- Identification of recombinant proteins and impurities using peptide mapping- Quantification of viral proteins using QQQ LCMS supporting upstream and downstream whole-virus vaccine development- Developed purity methods for recombinant proteins and supported stability studies using PA800 capillary electrophoresis and PerkinElmer GXII GelChip- Optimization.

Basel, Baselstadt, CH

- Support drug substance, drug product, formulation, pilot scale, and purification release- Perform method and data review for CMO method transfer- Optimize and automated PK method using AB Sciex 5500 Qtrap and Tecan Freedom Evo- Conduct PK studies for better understanding of ADC behavior- Optimize and Qualified Capillary Electrophoresis (CE) methods using.

San Diego, CA, US

- Conduct routine LCMS data analysis in a CLIA regulated environment - Analyze urine and oral fluid samples with Agilent Masshunter software for the presence of small molecule medications and illicit drugs tested on Agilent 1260 LC and Agilent 6410 Triple Quad MS systems

La Jolla, CA, US

- Conduct Fatty Acid Methyl Esterification (FAME) of algae cell culture for GC analysis- Conduct TOC and TN analysis of algae cell culture

Cambridge, MA, US

- Conduct routine testing in a GMP environment using defined SOPs and procedures- Perform high throughput methods using HPLC, DNA extraction and qPCR, 96 well plate ELISA, and capillary electrophoresis lab-chip formats to support development and manufacturing groups- Qualify new products on existing methods and write corresponding reports- Troubleshoot and.

Assay phenotypic growth patterns in Neurospora cressa for analysis of molecular and biochemical pathways under differing light, temperature, and supplement conditionsDesign experiments and document data and conclusions in a notebookWrite quarterly reports summarizing findingsTest cross Neurospora strains and inoculate media using sterile techniquePerform.