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Versatile Analytical Scientist with more than 16 years of research and development experience in biopharmaceutical analytics. Dedicated team member focused on developing and optimizing methods, implementing new technologies, and interpreting complex data sets to support project progression.
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Senior ScientistProteome Sciences PlcSan Diego, Ca, Us
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Scientist IiiHologic, Inc. Dec 2023 - PresentMarlborough, Ma, Us- Designed and managed feasibility and validation activities for transfer of chemiluminescent assays to SpectraMax L microplate reader- Conducted investigations on raw and finished materials using FTIR, HPLC, UPLC, Capillary Gel Electrophoresis, and TOF LCMS supporting QC and Manufacturing- Participated in product trend evaluations assessing out-of-trend results, root causes, and corrective actions -
Scientist 1, ProteomicsBelharra Therapeutics Feb 2022 - Dec 2023San Diego, California, Us- Established LCMS strategy for high throughput absolute quantitation of high value protein targets as part of Belharra proprietary probe screening- Devised statistical approaches to prioritize selective binding events observed in internal and external screens to be incorporated into Belharra data portals- Operated and maintained Thermo Altis QqQ, Eclipse/Lumos Tribrid, and Exploris LC-MS systems -
Senior ScientistPfizer Oct 2021 - Feb 2022New York, New York, Us- Operated and maintained Thermo Scientific Orbitrap Fusion Lumos and Eclipse LCMS systems- Worked to establish immunoprecipitation and LCMS methods for immunopeptidomic workflows supporting next generation immuno-oncology therapeutics- Performed top-down LCMS characterization of next generation antibodies supporting production and purification development -
ScientistPfizer Dec 2019 - Oct 2021New York, New York, Us- Managed high-resolution qTOF, Triple Quad, and MALDI MS instruments and applications for Early Bioprocess Development and Cancer Vaccines & Immunotherapeutics- Developed quantitative method for measurement of host cell proteins and enveloped virus characterization supporting downstream purification development using Bruker Impact II qTOF LC-MS/MS- Implemented nutrient and metabolite screening using Shimadzu 8060 QqQ LC-MS/MS and statistical techniques (ANOVA, ANCOVA, power analysis, etc.) for interpretation of nutrient consumption to guide upstream cell culture and virus production development- Performed tandem mass tag (TMT) and immunoprecipitation workflows with ThermoFisher Orbitrap Fusion Lumos system for targeted and unbiased proteomic support of early stage therapeutic research- Assayed mRNA product purity using Bruker Maxis HD qTOF LC-MS supporting mRNA vaccine production
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Senior Associate ScientistPfizer Apr 2014 - Dec 2019New York, New York, Us- Identification of recombinant proteins and impurities using peptide mapping- Quantification of viral proteins using QQQ LCMS supporting upstream and downstream whole-virus vaccine development- Developed purity methods for recombinant proteins and supported stability studies using PA800 capillary electrophoresis and PerkinElmer GXII GelChip- Optimization of BCA protein quantification method to assess novel antigen binding for broad range of formulation buffer candidates
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Development Scientific Associate IiNovartis Aug 2012 - Feb 2014Basel, Baselstadt, Ch- Support drug substance, drug product, formulation, pilot scale, and purification release- Perform method and data review for CMO method transfer- Optimize and automated PK method using AB Sciex 5500 Qtrap and Tecan Freedom Evo- Conduct PK studies for better understanding of ADC behavior- Optimize and Qualified Capillary Electrophoresis (CE) methods using Beckman Coulter PA800- Optimize SEC using Agilent 1260/1290 Systems- Design assay plans and release worksheets to transition PK method from development to high-throughput method and CRO transfer -
Associate ScientistMillennium Health Apr 2012 - Aug 2012San Diego, Ca, Us- Conduct routine LCMS data analysis in a CLIA regulated environment - Analyze urine and oral fluid samples with Agilent Masshunter software for the presence of small molecule medications and illicit drugs tested on Agilent 1260 LC and Agilent 6410 Triple Quad MS systems -
Research Associate (Temporary)Synthetic Genomics Apr 2011 - Apr 2012La Jolla, Ca, Us- Conduct Fatty Acid Methyl Esterification (FAME) of algae cell culture for GC analysis- Conduct TOC and TN analysis of algae cell culture -
Associate Scientist I (Ppd, Inc. Contractor)Biogen Idec Jul 2008 - Apr 2011Cambridge, Ma, Us- Conduct routine testing in a GMP environment using defined SOPs and procedures- Perform high throughput methods using HPLC, DNA extraction and qPCR, 96 well plate ELISA, and capillary electrophoresis lab-chip formats to support development and manufacturing groups- Qualify new products on existing methods and write corresponding reports- Troubleshoot and modify existing methods and SOPs- Review data submitted by other analysts- Document testing, training, and development work using GMP/GLP standards -
Independent ResearchBrody Lab, Ucsd Apr 2007 - Jun 2008Assay phenotypic growth patterns in Neurospora cressa for analysis of molecular and biochemical pathways under differing light, temperature, and supplement conditionsDesign experiments and document data and conclusions in a notebookWrite quarterly reports summarizing findingsTest cross Neurospora strains and inoculate media using sterile techniquePerform general lab functions including media prep, glass wash, and autoclave
Michael Sowers Skills
Michael Sowers Education Details
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Uc San DiegoBiochemistry & Cell Biology
Frequently Asked Questions about Michael Sowers
What company does Michael Sowers work for?
Michael Sowers works for Proteome Sciences Plc
What is Michael Sowers's role at the current company?
Michael Sowers's current role is Senior Scientist.
What is Michael Sowers's email address?
Michael Sowers's email address is mi****@****zer.com
What is Michael Sowers's direct phone number?
Michael Sowers's direct phone number is +185862*****
What schools did Michael Sowers attend?
Michael Sowers attended Uc San Diego.
What skills is Michael Sowers known for?
Michael Sowers has skills like Hplc, Elisa, Ce, Lc/ms/ms, Iec, Sec, Qpcr, Robotics, Method Qualification, Ich Guidelines, Antibody Drug Conjugates, Cmo Method Transfer.
Who are Michael Sowers's colleagues?
Michael Sowers's colleagues are Emanuela Leoni, Stephanie Ballweg, Peter Schulz-Knappe, Dr. Sebastian-Alexander Tölke, Jihyung Kim, Victoria Birse, Christopher Pearce.
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