Michael Pyle Email & Phone Number

Providence, RI, US

ZA

• Completed Tutor Training to understand and leverage online learning resources.
• Host weekly tutoring sessions on Zoom for ELL students to work towards their individual goals, including passing United States Citizenship exam.

Boston, Massachusetts, US

• Scanning and processing samples contributing to PathAI’s NASH Explore product.
• Data scanning on PathAI’s custom built microscope, which provides a unique data advantage.

• Long Term Substitute Teacher for 6th Grade English Language Arts and Social Studies classes of 20+ students; including lesson planning calculating term grades.
• Day-to-Day Substitute Teacher for Grades 4-7

Boston, Massachusetts, US

• Led team in creating, running, and decommissioning CAP/ CLIA Digital Pathology Scanning Lab, including assuming additional role as CLIA Lab General Supervisor.
• Received, processed, and scanned over 20,000 high-quality clinical trial samples as well as translation research samples.
• Collaborated on validation for PathAI’s AISight and AISight Dx, which received FDA 510(k) clearance and CE Mark.
• Executed extensive qualification (IQ/OQ/PQ) of CLIA Lab Scanners.
• Managed and oversaw daily operations of the digital pathology lab and collaborated across a wide range of departments including: Scientific Programs, Business Development, Quality, Regulatory, and Machine Learning.
• Produced high-quality scanning pathology slides for internal and external initiatives and communicated with external vendors to troubleshoot digital imaging equipment.

Boston, Massachusetts, US

• Research Assistant III – De Vivo Lab and Ghobrial Lab
• Created sample processing workflow and maintained database for up to 50,000 patient blood samples as part of the Stand Up to Cancer - PROMISE Blood Collection Project in collaboration with Dana-Farber Cancer Institute.
• Managed Harvard’s IRONMAN Biorepository Project for over 1000 patients and more than 50 participating sites.
• Cross-trained on multiple Genotyping protocols including Telomere assay, RNA-Seq, and various DNA extraction methods as part of the Genotyping Core Facility.
• Oversaw inventory and ordering of lab supplies using Harvard’s internal ordering system (HCOM).

Brookline, MA, US

Boston, MA, US

• Research Assistant III – Heng Lab
• Deployed Definiens analysis software to provide IHC analysis for TMA and Whole Slide Images for 50+ samples.
• Learned R programming to inventory, organize, and analyze database of over 10,000 images.
• Processed over 1000 patient samples as part of PIK3CA project and presented data during meetings.
• Gathered medical records for over 300 patients to establish a database for transgender and gender nonconforming study; became well-versed in breast pathology to annotate over 200 patient images.
• Assumed role as Lab Safety Officer to ensure all SOP’s were followed and attended quarterly lab safety meetings and assisted in hiring and overseeing day-to-day work of Lab Technicians and summer interns.

Boston, MA, US

• Laboratory Technician II – Perrimon Lab
• Worked within Drosophila RNAi Screening Center (DRSC) group and the Perrimon Lab to oversee Drosophila crosses post-injection and screened for mutant lines.
• Discussed, designed, and executed experimental workflows in a team environment.
• Assisted Postdoctoral researchers with various research projects.

• Laboratory Technician I
• Mapped injected DNA plasmids to particular chromosome of transgenic Drosophila melanogaster using genetic mating schemes; Prepared virginator stocks for use in mating schemes by screening for phenotypic traits.
• Performed Drosophila genomic DNA extractions for use in confirming presence of transgene and coordinated shipment of Drosophila samples to ensure timely delivery for customers.

• Analyzed 1000 cells for quantification of protein localization which resulted in Honor’s Thesis titled “The Role of SUMOylation in Dorsal Nuclear Localization.”
• Created DNA constructs for tagging proteins with fluorescent tags to examine the nuclear/cytoplasmic shuttling under different mutant conditions.
• Presented research findings through lab meetings and poster presentations at UMass Boston and Harvard Medical School.

Bachelor Of Science (B.S.), Biology, General

Education record