The fascinating complexity of the bone marrow (BM) niche orchestrates the spatiotemporal maintenance and expansion of hematopoietic stem cells and progenitor cells (HPCs) to ensure healthy haematopoiesis. Deregulation of these interactions is bound to drive bone marrow failure and malignancies causing anaemia or cancer. Nevertheless, the regulatory interactions of the BM niche with HPCs during expansion and differentiation in healthy and malignant haematopoiesis are poorly understood. Moreover anaemia and most myeloid-typed leukemic-derived malignancies are characterised by the marked accumulation of myeloid-committed HPCs, which affects the interplay between the BM niche and healthy HPCs, and accelerates disease formation. Increased understanding of the underlying interactions between the BM niche and HPCs is required to improve treatment options of myeloid-marked BM failure and leukaemia. My research group aims to unravel the mechanisms driving the instructive interactions between the BM nice and myeloid/erythroid-committed HPCs during healthy and malignant haematopoiesis. Currently we have different opportunities to do a master internship in my group:https://www.sanquin.org/binaries/content/assets/en/research/student-projects/uncovering-the-role-of-e-cadherin-in-hematopoietic-progenitors-to-improve-anemia-in-hematopoietic-malignancies.pdfDon't hesitate to contact me if you are interested.
Listed skills include Cell Biology, Molecular Biology, Cell Culture, Immunology, and 29 others.