Department of Cellular and Tissue Genomics

Lab of Stephen Quake, Department of BioengineeringUsing single-cell genomics to elucidate mechanisms of brain aging and memoryPublications:• Chen MB*, Yang A*, Yousef H*, Lee D, Lehallier B, Schaum N, Quake SR+, Wyss-Coray T+, “Brain endothelial cells are exquisite sensors of age-related circulatory cues”, Cell Reports, In Press (2020)• Chen MB*, Jiang X*, Quake SR+, Südhof TC+, “Persistent transcriptional programs are associated with remote memory in diverse cells of the medial prefrontal cortex”, Nature, 2020.• Yousef H, Czupalla C, Lee D, Chen MB, Burke A, Zera KA, Zandstra J, Berber E, Lehallier B, Mathur V, Nair RV, Bonanno L, Yang AC, Peterson T, Buckwalter M, Quake SR, Butcher EC, Wyss-Coray T, “Aged blood activates microglia and reduces neural precursor cell activity through brain endothelial VCAM1 in the mouse hippocampus,” Nature Medicine, 2019.• The Tabula Muris Consortium (Chen MB: Logistical coordination, Organ collection and processing, Computational data analysis groups). “Single-cell transcriptomics of 20 mouse organs creates a Tabula Muris,” Nature, 562 (7727), 367, (2018)

Roger Kamm Lab, Department of Mechanical and Biological EngineeringEngineering on-chip microvascular models for studying circulating tumor cell dynamics and metastasisPublications:• Chen MB, Yu C, Froese J, Whisler J, Shin Y, Kamm RD, “On-chip microvasculature assay for real-time visualization and quantitation of tumor cell extravasation dynamics.” Nature Protocols, 2017. • Chen MB, Hajal C, Benjamin DC, Yu C, Azizgolshani H, Kamm RD, “Inflamed neutrophils sequestered at entrapped tumor cells via chemotactic confinement promote tumor cell extravasation.” Proceedings of the National Academy of Sciences, 2018. • Chen MB, Lamar JM, Hynes RO, Kamm RD, “Elucidation of the roles of tumor integrin beta-1 in the extravasation stage of the metastasis cascade.” Cancer Research, 2016. • Li R*, Chen MB*, Kamm RD, “On-a-chip applications for disease modeling, drug discovery and personalized medicine, Chapter 14: Cancer metastasis-on-a-chip,” CRC Press, 2016. • Chen MB, Whisler J, Jeon JS, Kamm RD, “Mechanisms of tumor cell extravasation in a microvascular network platform.” Integrative Biology, 2013. • Papa, AL, Jiang A, Korin N, Chen MB, Langan E, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto A, Mammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE, “Platelet Decoys inhibit thrombosis and prevent metastatic tumor formation,” Science Translational Medicine, 2019.

Craig Simmons Lab, Department of Mechanical EnginereingDevelopment of a 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell–cell interactionsPublications:Chen MB, Srigunapalan S, Wheeler AR, Simmons CA, “A 3D microfluidic platform incorporating methacrylated gelatin hydrogels to study physiological cardiovascular cell-cell interactions.” Lab Chip, 2013.

Organized and delivered outreach and awareness events to high school students about the study of science and engineering.

Co-founded an annual engineering design competition for high school students in Ontario.