Michelle Scriver Email & Phone Number

Nelson, New Zealand

Supervise the work of laboratory technicians, interns and junior researchers.Lead and contribute to research and development projects. Design experiments, and supervise their implementation, perform analysis of resultsLead and contribute to scientific publications and reportsLead and contribute to team meetingsContribute to developing proposals and.

Nelson, New Zealand

• Oversee laboratory operations, including sample tracking, site preparation, and supplies management.
• Develop and implement operational laboratory protocols.
• Establish high-throughput sequencing (HTS) protocols for the Illumina MiSeq/NextSeq platform and conduct and supervise HTS analyses.
• Design experiments, supervise implementation, and analyze results.
• Present findings to clients and key stakeholders.
• Contribute to scientific publications and reports.

Nelson, New Zealand

• Pursuing a PhD in molecular ecology focusing on optimizing sampling approaches and designs for eDNA/eRNA based marine biosecurity surveillance. The research will help to answer critical questions regarding eDNA/eRNA.
• Enhance molecular detection methods such as eDNA and eRNA assays, including droplet digital PCR and metabarcoding techniques, for marine biosecurity applications.
• Incorporate innovative technologies to further improve molecular detection methods.
• Contribute to the Marine Biosecurity Toolbox, a national initiative focused on developing tools for pest prevention and detection.
• Design experiments to refine sample collection strategies for effective biodiversity monitoring and marine pest detection.
• Lead scientific article writing to disseminate research findings and insights.

Philadelphia, PA, United States

• Led group organization efforts, overseeing onboarding processes and implementing systems for project management, including centralized databases. Collaborated with leads to establish efficient workflow and enhance team.
• Actively engaged in scientific working groups to advance AAV vector knowledge across disciplines within our team, particularly in genomics.
• Facilitated collaboration and communication between teams, such as automation, to exchange knowledge on technologies supporting our team's objectives.
• Actively involved in designing, researching, and developing assays to contribute to the development of AAV vectors for pre-clinical trials.

Philadelphia, PA

• Collaborated within the Liver Therapeutic Area of the Translational Research Department to optimize gene therapy vector potency and efficacy.
• Supported scientist-led projects to improve gene therapy vector specificity, regulatability, and durability.
• Conducted routine bioanalytical assays across various pipeline programs, including ELISA, cell-based NAb assay, qPCR, and Western Blot.
• Participated in implementing new assays and optimizing/validating bioanalytical assays.
• Managed samples and materials for translational research purposes.
• Maintained meticulous and timely records of work.

Philadelphia, PA, United States

• Team lead for the quality control microbiological team, oversaw the training programs for new personnel on microbiological and biochemical QC SOPs.
• Compiled and interpreted quality control data to identify root causes and recommend Corrective and Preventive Actions (CAPAs).
• Actively contributed to developing innovative techniques to enhance QC biochemical and microbiological assays.
• Spearheaded updates to various SOPs as the lead author, ensuring alignment with evolving cGMP and FDA regulations.
• Performed biochemical and molecular biology assays on various test articles following established Standard Operating Procedures (SOP) and cGMP guidelines.
• Designed, prepared, qualified, stored, and tracked target-specific qPCR reagents for determining AAV concentrations.

Philadelphia, PA

• Provided quality control for clinical grade vector using current Good Manufacturing Practices (cGMP) and GLP
• Participated in internal audits to evaluate for compliance and identify areas for improvement
• Conducted comprehensive analytical testing for cGMP vector products to ensure safety, identity, potency, purity, and stability.
• Implemented microbiological monitoring to maintain GMP clean room environments.
• Provided technical support for QC assay development and optimization, contributing to the writing of reports, SOPs, and change controls for existing procedures and incident management.

Montreal, QC, Canada

• Validated biomarkers of chemoresistance in TNBC using RT-qPCR, RT-PCR, Western blots, siRNA, cytotoxicity assays, and immunofluorescence techniques.
• Conducted in vitro experiments with mammalian cancer cell lines.
• Designed qPCR primers, optimized assays, and employed critical thinking to troubleshoot techniques, contributing to report preparation on findings and methodologies.
• Planned, executed and documented experiments
• Reviewed scientific journal articles and kept up to date with cancer research
• Prepared reports of findings, investigative methods and lab techniques

Montreal, QC, Canada

• Analyzed the mechanisms of chemoresistance in triple negative breast cancer (TNBC)
• Technically validated potential biomarkers for chemoresistance in TNBC with RT-qPCR, and RT-PCR
• Conducted in-vitro experiments using mammalian cancer cell lines
• Designed qPCR primers and optimize qPCR assay
• Prepared reports of findings, investigative methods and lab techniques

Scarborough, ON, Canada

• Calibrated and operated standard laboratory equipment including autoclave, incubators, pH meter and scales
• Produced agar plates and media for inspection of food products for bacteria
• Guaranteed the laboratory was well-stocked and resourced
• Carried out routine tasks accurately and followed strict methodologies protocols and SOPs

Peterborough, ON, Canada

• Investigated and evaluated the use of eDNA for monitoring eleven aquatic invasive plant species, including chloroplast DNA extraction, sequencing, and primer design.
• Collaborated with peers and supervisor to publish findings in a scientific journal article.

Peterborough, ON, Canada

• Collected plant samples from across the country for Ph.D. and Master candidates’ research
• Employed a methodology approach to collecting samples and well documented each location during collection
• Organized, and sorted thousands of plant samples
• Extracted DNA from multiple plant samples for future experiments

Peterborough, ON, Canada

• Used RT-PCR (Reverse Transcription PCR) to assay the gene expression in Giardia lambila.
• Successfully expressed and purified the recombinant polyhistidine-tagged alkaline phosphate

Doctor Of Philosophy - Phd, Molecular Ecology

Activities and Societies: Leader of the Joint Graduate School Post-Graduate Student Consortium

Master Of Science - Ms, Applied Biotechnology

Activities and Societies: BioConnect Executive Committee

Bachelor Of Science (B.Sc.), Forensic Science