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Development of ratiometric red/NIR fluorescent hybrid probes to evaluate drug transport, pH and redox changes in the malaria parasite’s food vacuole. ~ Multi-steps synthesis, Retro-synthesis, design of new fluorophores, new methodology development, biology / chemistry interface.

Design of new reagent in organofluorine chemistry and development of new methodologies for the –CF2CF2- incorporation into aliphatic systems ~ Organofluorine chemistry, design of new reagent, methodology development, transfers of selectively fluorinated functional groups, click chemistry.

Synthèse et fonctionnalisation directe catalytique de la liaison C-H d’imidazolones. Nouvel accès aux fluorophores analogues de la GFPEncadrements de 11 stagiaires

Development of a sequential alcohol oxidation-Prins cyclization: direct access to tetrahydropyrans.Prins cyclization, tandem oxidation process, methodological studies, organocatalysis reaction (enantioselective oxa-Michael-aldol sequential), enantiomeric excess quantificationSupervisors: Dr. Fabienne Fache, Pr. Olivier Piva