I’m now retired from my previous role as Senior Director of Innovation in the NCE Molecular Discovery department in Medicinal Science and Technology. I am a GSK Alumni Senior Fellow and an Adjunct Professor at Imperial College chemistry department. My final role at GSK was as Senior Director acting an internal science consultant promoting and challenging ideas at the interface of chemistry and biology both within GSK and through our external engagement with academia.Recent activities included:Leading GSK’s Cell Concentration project which delivers methodology for determining the total and free cellular concentration of discovery molecules.Helping re-establish and acting as interim leader of GSK’s Chemical Biology and High Throughout Experimentation groups and developing new tools and technologies to explore new targets. Active engagement in projects including gene editing, molecular glues, protein degradation, CETSA, single cell protein quantification, MS imaging, and medicinal chemistryPreviously I was a Director in Chemical Sciences at GSK in the UK responsible for leading departments involved in computational chemistry, protein crystallography, biophysics and protein MS. Since joining Glaxo in 1986, I have been involved in the introduction and development of many key concepts in drug discovery – including Computational Chemistry, Fragment Screening, Automation in Protein Crystallography, MALDI tissue imaging, Molecular Complexity, RECAP analysis, Cell concentration screening, and ligandability assessment. I have been at the forefront of our efforts to reduce attrition in drug discovery through focussing on physicochemical properties of compounds through data analysis.I am a past chair of the Society for Medicines Research SMR and the Molecular Graphics and Modelling Society MGMSI was the 2024 inductee into the RSC BMCS Hall of Fame and delivered a lifetime achievement plenary lecture at the EFMC Rome conference. I am a fellow of the Royal Society of Chemistry, and an honorary member of the MGMS.