Formulation of new products for health and wellness. Overseeing production of new products on production scale.Preparation of lab scale batches of products.Flavoring a variety of products from emulsion based gels to powder drink mixesCreating novel delivery methodsPresenting information on products to co-workers and distributors

Subject matter expert in the area of organic synthesis. Teacher/trainer for military groups in the area of CWA, HME and drug chemistry.Develop synthetic routes to compounds of interest.Develop new course material/training briefs/practical exercises.

Process research and development. Prepare and execute large scale synthetic routes for the manufacture of drug products and API.

Analysis of unknown compounds for the presence of controlled substances or poisons. Crime scene analysis and documentation. Instrument validation, calibration and maintenance. Serology.

Managed outsourcing efforts with CROs in China including managing meetings, designing compounds to be synthesized, designing synthetic pathways, and prioritizing synthetic efforts- Maintained analytical instrumentation (Agilent HPLC, Waters HPLC and LCMS) Extensive use analytical instrumentation to aid in the identification of small molecules.- Successfully designed compounds to optimize ADME and toxicological properties, particularly focused on removing hERG liabilities, improving solubility and metabolic stability while maintaining potency- Designed and synthesized small molecules with high affinity for both kinase and non-kinase targets- Completed small scale process optimization to facilitate synthesis of 1-10 g quantities of API for in house in vivo and efficacy studies.- Optimized salt forms for improved solubility to facilitate formulation of APIs.- Extensive use of molecular modeling to assist in the design of novel inhibitors.

- Designed and synthesized compounds to inhibit novel kinase targets- In the last six months synthesized nearly one hundred compounds, including several multi gram syntheses for MTD and xenographt studies.- Completed process optimization and scale-up for IND enabling studies.- Worked with two separate scaffolds which bind to the hinge region of the enzyme, modifying zone A (sugar binding pocket) and zone C (phosphate binding pocket) to increase potency, infer selectivity, increase solubility, minimize negative attributes such as CYP inhibition, and expand the intellectual property space around our molecules. - Worked towards the discovery of drugs to block various key stages in the HIV lifecycle- Synthesized over four hundred novel compounds for an SAR to increase potency, metabolic stability and solubility towards the goal of developing an IND candidate in Myriad's anti-HIV program- Developed ideas that lead to a greater than 100 fold increase in drug potency for our lead compound- Developed ideas for and synthesized pro-drugs in an attempt to increase oral bioavailability through solubility enhancement.

Was a major contributor towards the process for AG13736 (a potential cancer drug entering phase 3 development) and PF-194223 (a PPAR inhibitor for the treatment of diabetes entering phase 1 development), also worked with the biotransformation team towards a new manufacturing route for atorvastatin (Lipitor) involving novel enzymatic reactions.- Oversaw and supported campaigns; produce drug product in the 20+ Kg range.- Optimized synthetic routes obtained from discovery for cost effectiveness and scalability.- Designed and implemented alternative synthetic routes to drug targets in order to save on overall cost and efficiency- Developed methods of purification that are easily scalable (particularly eliminating column chromatography)- Applied various crystallization techniques to obtain desired polymorphs- Extensive work with Pd catalyzed coupling reactions i.e. Suzuki, Miyaura, Buchwald, Heck etc. and their palladium free alternatives, and various palladium removal techniques - Ran campaigns to synthesize Kg quantities of active pharmaceutical intermediate - Developed reactions for scale-up that were outsourced and used to synthesize multiple Kg of GMP starting material. - Trained extensively for and worked under cGMP conditions

Synthesis of nitrogen containing heterocycles for use as intercalators to study nucleic acid small molecule interactions. - Used techniques such as NMR, HPLC, GC, mass spec., IR, UV-Vis, and Fluorescence spectroscopy. Taught organic chemistry lab and lecture courses to undergraduate students for 5 semesters