Founding Member And Scientific Advisor
Current
Jan 2020 - Present
AeroLeads people directory · profile
Mike Clark Email & Phone Number
Immunologist and Antibody Engineering Consultant
at
mAbsolve
1 work email found
@cam.ac.uk
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4 data sources
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Current company
Role
Immunologist and Antibody Engineering Consultant
Location
Settle, England, United Kingdom
Who is Mike Clark? Overview
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Quick answer
Mike Clark is listed as Immunologist and Antibody Engineering Consultant at mAbsolve, based in Settle, England, United Kingdom. AeroLeads shows a work email signal at cam.ac.uk and a matched LinkedIn profile for Mike Clark.
Mike Clark previously worked as Founding Member and Scientific Advisor at Mabsolve and Co-Owner and Managing Director at Clark Antibodies Ltd. Mike Clark holds Phd, Molecular Immunobiology from University Of Cambridge.
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Email format at mAbsolve
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*@cam.ac.uk
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Profile bio
About Mike Clark
Now retired from academia and semi-retired as a consultant (It takes a lot to persuade me that today's not a good day to go walking, cycling, skiing, birdwatching etc) However I have extensive experience of the development of antibody based therapeutics including recombinant and bispecific antibodies. An inventor of the first fully humanised antibody CAMPATH (alemtuzumab) and several other humanised therapeutic antibodies to antigens such as CD3 (TRX4 otelixizumab) and CD4 (TRX1). Alemtuzumab is used off-label for organ and marrow transplantation and was approved for treatment of B-CLL from 2001. The antibody was later reformulated and repurposed under the tradename Lemtrada for use in the treatment of Multiple Sclerosis. I was also involved in some of the earliest clinical uses of CD3 as a monovalent and also as a bispecific (CD3xCD19) therapeutic agent.My subsequent work concentrated on antibodies with modified Fc properties and some of these modifications found their way into antibodies such as Tolerex / GSK's otelixizumab, and several of Pfizer's antibodies such as tanezumab, ponezumab, RN316 and RN564. The migraine treatment fremanezumab also includes one of these Fc modifications. In collaboration with the UK NHSBT we also investigated the use of a modified antibody to HPA-1a antigen for treatment of feto-maternal allo-immune thrombocytopenia (FMAITP).I've also worked as a consultant or on SABs on many commercial aspects of humanisation, deimmunisation, effector function optimisation and other aspects of antibody engineering for human therapy.I was more heavily involved including as an investor in the commercial early phase startups of Absolute Antibody Ltd and its spinout mAbSolve LtdIn academia I spent the years 1990 until my retirement in 2014 organising, lecturing and examining undergraduate courses in infectious diseases and immunology. In later years I also got involved in university politics serving as an elected member of Cambridge University's Council and also on its Finance Committee. Additionally I've experienced and influenced the evolution of Cambridge University's technology transfer policies over the years 1981-2014 (including UK Government's NRDC becoming the privatised BTG).Specialties: Humanisation and also Fc effector function modification. Functions of IgG isotypes and allotypes.
Listed skills include Molecular Biology, Biotechnology, Immunology, Cell, and 37 others.
Current workplace
Mike Clark's current company
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11 roles · 48 years
Mike Clark work experience
A career timeline built from the work history available for this profile.
Co-Owner And Managing Director
CurrentConsultancy and IP services to Biotech and Biopharma in the field of antibody engineering and antibody therapeutics.
Jan 2009 - Present
Scientific Advisor
Absolute Antibody Ltd is a privately funded startup company developing next generation reagents for the research and diagnostic market.
Apr 2014 - Jan 2021
Trustee
Clark Bradbury Charitable Trust
The Clark Bradbury Charitable Trust was established by Mike Clark and Jane Bradbury and was a charity registered (No 1129841) with the Charity Commissioners in England and Wales. It was a grant awarding charity which gave money to other charitable causes selected as worthy by the Board of Trustees. The Charitable Trust was wound up in 2018.
Feb 2009 - Nov 2018
Reader In Therapeutic And Molecular Immunology
An established post at the University of Cambridge within the Department of Pathology. I retired with a total of 33 years of service with the University of Cambridge on 30th September 2014.
Oct 2007 - Sep 2014
Finance Committee Member Appointed By The University Council
The Finance Committee is a Statutory Standing Committee of the University of Cambridge which reports to the University Council. It is responsible for overseeing the management of the financial affairs and capital assets of the University. A principle duty of the Committee is to prepare the annual statement of accounts for review and approval by the Council.
Jul 2005 - Dec 2012
Elected Member Of Council
Elected to the Council in the capacity as a Reader or Professor within the University. The Council is the executive and policy-making body of the University. The members of Council also perform the role of Trustees regarding the University's charitable status.
May 2009 - Dec 2010
Elected Member Of Council
The Council is the executive and policy-making body of the University. The members of Council also perform the role of Trustees regarding the University's charitable status.
Jan 2005 - Dec 2008
Lecturer In Therapeutic And Molecular Immunology
University Of Cambridge, Department Of Pathology
Research into therapeutic applications of recombinant antibodies. In particular looking at Fc modifications and the roles of antibody allotypes and isotypes.
Jul 1990 - Oct 2007
Postdoctoral Research Scientist
University Of Cambridge, Department Of Pathology
Working in the laboratory of Dr Herman Waldmann on a programme grant from the Medical Research Council to study the immunobiology of bone-marrow transplantation. During this time the research group discovered and invented therapeutic antibodies such as CAMPATH (CD52) and also therapeutic antibodies to CD3, CD4 and CD45.
Oct 1981 - Jul 1990
Research Student In Dr Cesar Milstein'S Laboratory
A research studentship carrying out research using the newly discovered technology of hybridomas and monoclonal antibodies. My PhD thesis was completed in 1982 with the title "Antibodies in Somatic Cell Hybrids"
1978 - 1981
~3 yrs
2 education records
Mike Clark education
Phd, Molecular Immunobiology
B.Sc, Biochemistry
FAQ
Frequently asked questions about Mike Clark
Quick answers generated from the profile data available on this page.
What company does Mike Clark work for?
Mike Clark works for mAbsolve.
What is Mike Clark's role at mAbsolve?
Mike Clark is listed as Immunologist and Antibody Engineering Consultant at mAbsolve.
What is Mike Clark's email address?
AeroLeads has found 1 work email signal at @cam.ac.uk for Mike Clark at mAbsolve.
Where is Mike Clark based?
Mike Clark is based in Settle, England, United Kingdom while working with mAbsolve.
What companies has Mike Clark worked for?
Mike Clark has worked for Mabsolve, Clark Antibodies Ltd, Absolute Antibody, Clark Bradbury Charitable Trust, and University Of Cambridge.
How can I contact Mike Clark?
You can use AeroLeads to view verified contact signals for Mike Clark at mAbsolve, including work email, phone, and LinkedIn data when available.
What schools did Mike Clark attend?
Mike Clark holds Phd, Molecular Immunobiology from University Of Cambridge.
What skills is Mike Clark known for?
Mike Clark is listed with skills including Molecular Biology, Biotechnology, Immunology, Cell, Antibodies, Monoclonal Antibodies, Biochemistry, and Life Sciences.
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