Michael Floren, Ph.D. Email & Phone Number

Centennial Colorado

Boulder, Colorado

• Directed research, product development and commercialization strategies for proprietary medical device coatings.• Oversaw business development on customer segment, business modeling, market ecosystem, and competitive landscape.• Negotiated non-disclosure and material transfer agreements with industry partners. • Pursued venture capital for patent licensing, R&D sponsorship, and product commercialization.

Boulder, Co

CU Research-to-Market (R2M) is a customer discovery accelerator program for students, faculty and staff of CU-Boulder and their business ventures. During this program, the cohort was exposed to several business mentors and received coaching on customer segment, business canvas modeling, market ecosystem, competitive landscape and pitching. Dr. Floren was invited along with 15 other teams to participate in the 2019 cohort.

Greater Denver Area

Research Focus:• Vascular Disease and Tissue Remodeling: Investigated the structural, mechanical and compositional changes in pulmonary arteries during onset and progression of pulmonary hypertension.• Animal Models for Vascular Disease: Gained first-hand knowledge of pulmonary vascular disease in both rodent and bovine animal models.• Advanced in vitro models for disease: Developed complex microenvironments that emulate in vivo disease conditions by combining innovations in… Show more Research Focus:• Vascular Disease and Tissue Remodeling: Investigated the structural, mechanical and compositional changes in pulmonary arteries during onset and progression of pulmonary hypertension.• Animal Models for Vascular Disease: Gained first-hand knowledge of pulmonary vascular disease in both rodent and bovine animal models.• Advanced in vitro models for disease: Developed complex microenvironments that emulate in vivo disease conditions by combining innovations in materials science, molecular biology and engineering. Technical Skills:• Combined novelties in photo-clickable polymer chemistry and materials fabrication to design advanced in vitro disease models to study events associated with pulmonary hypertension• Learned dissection, isolation and cell expansion techniques from both human and animal tissues to provide cell and tissue models for characterization and advanced in vitro disease model synthesis. • Gained diverse knowledge of biomarkers for inflammation and fibrosis, flow cytometry for cell sorting, and proteomic evaluation by mass spectroscopy of vascular tissue composition. .• High-throughput cell screening and disease modelingPublications:https://scholar.google.com/citations?user=GDLAZtsAAAAJ&hl=enSupported by: NIH T32 Post-Doctoral Fellowship - 2T32 HL07171-39 Show less

Boulder, Co.

• Devised and patented a technology combining conventional DNA microprinting with engineered, nanofibrous polymers to produce diverse microenvironments to screen cellular activity• Gained proficiency in nanofibrous materials characterization by rheology, mechanical testing (MTA), scanning electron microscopy (SEM) and image analysis. • Refined knowledge of cell culture techniques and sterile practice for ten diverse cell lines including stem, terminally differentiated, cancer or immune… Show more • Devised and patented a technology combining conventional DNA microprinting with engineered, nanofibrous polymers to produce diverse microenvironments to screen cellular activity• Gained proficiency in nanofibrous materials characterization by rheology, mechanical testing (MTA), scanning electron microscopy (SEM) and image analysis. • Refined knowledge of cell culture techniques and sterile practice for ten diverse cell lines including stem, terminally differentiated, cancer or immune cells. Show less

Trento Area, Italy

• Devised a novel production of porous, silk fibroin hydrogels for biomedical applications using high-pressure carbon dioxide.• Helped design and fabricate a high-pressure reactor for production of porous polymeric materials. • Utilized various techniques to characterize porous materials: SEM, Fourier-transform infrared spectroscopy (FTIR), MTA, mercury porosimetry, and differential scanning calorimetry (DSC).

• Contributed to clinical protocols, feasibility studies, site initiation visits and FDA documentation towards a Phase II metastatic breast cancer drug.• Presented findings for three-month long survey of clinical site initiation and satisfaction to company CEO and CSO resulting in adjustments to improve clinical site efficiency.

Helped design and synthesize AB diblock and ABA triblock copolymers using anionic and controlled free radical polymerization techniques for novel stimuli-responsive hydrogel technologies including membrane separations, drug delivery, biomedical adhesives, and tissue engineering scaffolds. Compiled polymerization kinetic data for the RAFT polymerization of poly(dimethylacrilamide) (PDMA) using 1H NMR and size-exclusion chromatography (SEC) to characterize various polymer samples.

Doctor Of Philosophy (Phd), Biomedical/Medical Engineering

Doctor Of Philosophy (Phd), Material Science & Engineering

Masters Of Engineering, Bioengineering And Biomedical Engineering

Bachelor Of Science (B.S.), Chemical Engineering