Mitchell Lobo Email & Phone Number

Boston, Ma, Us

Advisor: Dr. Iman Zaghloul Thesis Title: Pharmacokinetics and Pharmacodynamics of a Novel Iron Chelator•Developed and validated a method for small molecule iron chelator using LC-MS/MS method using derivatization agent to quantify the drug in biological samples.•Designed and conducted various pharmacokinetics (dose escalation, mass balance, protein binding, bioavailability, bile duct cannulation) and pharmacodynamics experiments to evaluate the in-vivo efficacy and safety profile•Performed compartmental modeling using WinNonlin to understand pharmacokinetic parameters and guide the dosage regimen of a small molecule iron chelator.•Managed and mentored a team of junior graduate students, and provided training and guidance on experimental techniques and data analysis.Course Title: Advanced Pharmacokinetics (PSB.430.B)Role: Assist in teaching PharmD students

South San Francisco, California, United States

• Conducted a comprehensive investigation of the predictive performance of early-stage allometry to estimate human clearance for the entire internal AbbVie dataset and literature compounds, focusing on low-clearance compounds and degradomers.• Assessed the accuracy of human clearance predictions across different species (single and multiple species scaling) and provided insight and guidance on the decision-making regarding species selection to adhere to ethical considerations, refining and reducing animal use.• Delivered oral presentations to key stakeholders within the QTAS organization.• Participated in AbbVie's "Week of Possibilities" as a volunteer, contributing to global community service initiatives, and demonstrating commitment to corporate social responsibility and collaborative team efforts.

Lowell, Massachusetts, United States

•Executed design of experiments (DOE) to prepare various hydrogel formulations of drug/carrier (LuCI), an oral pill for obesity and Type 2 Diabetes (T2D), optimizing crucial parameters such as drug encapsulation efficiency and loading capacity. •Employed analytical skills to quantify drug release using HPLC from hydrogel formulation both in vitro and in vivo, ensuring thorough assessment of stability and efficacy of the formulations. •Collaborated with external consultants and CRO to conduct comprehensive pharmacokinetic analysis.•Managed study data, ensuring compliance, while communicating strategy updates to teams and stakeholders, and delivering scientific presentations in diverse settings.

Boston, Massachusetts, United States

•Executed pharmacokinetic analysis to assess therapeutic efficacy and safety of a small molecule and NCHG (Nanochelator incorporated in hydrogel formulation) in iron overload rodent models, elucidating the kinetics of iron removal and establishing a dose-response relationship for iron chelation. •Managed and characterized sickle cell, thalassemia, and other genetic colonies of rodents exhibiting iron overload and iron deficiency.•Developed and refined work protocols, SOPs, and procedures under the supervision of postdoctoral researchers and senior graduate students, while also providing support to their projects and fostering collaboration with external academic institutions.

Boston, Massachusetts, United States

Course Title: Undergraduate research project (PSB.350.B)Role: Mentored undergraduate students in pre-formulation, analytical studies, method development, and validation using HPLC, UV-Vis spectrophotometer.

Boston, Massachusetts, United States

Advisor: Dr. Iman Zaghloul Collaboration: TUFT'S UniversityThesis Title: Evaluation of age-related effects on the pharmacokinetics of hepatically metabolized drug phenylbutazone•Developed and validated an HPLC-UV and LC-MS/MS method to quantify phenylbutazone and its metabolite (oxyphenbutazone) in horse plasma.•Performed pharmacokinetic data analysis, non-compartmental modeling, and simulations for drug and metabolite profiling using WinNonlin to predict a treatment regimen in two age groups.

Doctor Of Philosophy - Phd, Pharmaceutics

Master Of Science - Ms, Pharmaceutics

Diploma, Forensic Science And Criminal Law

Bachelor Of Pharmacy (B.Pharm.)