Yu Mi Email & Phone Number

Austin, Texas, United States

Lexington, Massachusetts, Us

Seattle, Washington, Us

Chapel Hill, Nc, Us

• Led a project that developed dual immunotherapy nanoparticle (DINP) using antibodies-conjugated polymeric nanoparticles to improve T-cell activation and cancer immunotherapy, leading to a UNC start-up company for clinical translation of the product• Led a project that developed biologically targeted photo-crosslinkable nanopatch (pCNP) to prevent postsurgical peritoneal adhesion, resulting in a more effective and safer barrier than a commercially available adhesion barrier Seprafilm® on a rat parietal peritoneal excision adhesion model• Led a project that developed neoantigen nanovaccines combining in silico and in vivo neoantigen screening and preclinical efficacy study for personalized cancer treatment in collaboration with scientists and clinicians in immunology and nanotechnology• Supervised visiting scholars and graduate students to study the mechanisms of nanotherapeutics’ hepatotoxicity for different hepatotoxic compounds using lipid-coated polymeric nanoparticles on different mouse strains and identified the key factors as drug release kinetics and macrophage uptake

Houston, Texas, Us

• Led a project that developed a porous silicon-based micro/nano composite (MNC) that is capable of simultaneously delivering chemotherapeutic agents and small interfering RNA (siRNA) to the lung, leading to improvement for a product at clinical translation stage• Studied the nano-bio interaction and developed matrix metalloproteinase-2 (MMP2) enzyme-responsive multistage vector for increased intracellular accumulation of agents in cancer cells in a mouse model of melanoma lung metastasis

Singapore, Sg

• Developed vitamin E TPGS-based polymers including TPGS2k, TPGS-Cisplatin, TPGS-siPlk1 and PLA-TPGA for targeted multimodality treatment of cancer, resulting in greater efficacy of chemotherapeutics • Developed herceptin functionalized polyhedral oligomeric silsesquioxane-conjugated oligomers silica/iron oxide nanoparticles for CTC sorting and detection, leading to a multiply engineered structure that can be used for either traditional immunomagnetic methods or microfluidic devices

Doctor Of Philosophy (Ph.D.), Chemical And Biomolecular Engineering

Bachelor'S Degree, Materials Science And Engineering