Mark Lalli Email & Phone Number

Cambridge, Massachusetts, US

Cambridge, MA, US

• Analyzed cell agriculture manufacturing processes.

• Led a team of scientists to streamline manufacture of core programs including scale up of adherent cells into a bioreactor platform.
• Developed protocols for cGMP manufacture of cellular drug substance and drug product.
• Supported regulatory filings and amendments for UK, EU, Brazil, and USA.
• Led optimization work for cryopreservation of drug substance and drug product.
• Served as person-in-plant and tech transfer lead for SIG-001, -002, -005, and -007.
• Created xeno-free media adapted banks of drug substance precursor cell lines.

North Chicago, Illinois, US

• Developed control strategies and processing methods for continuous antibody-drug conjugate (ADC) manufacture.
• Optimized countercurrent tangential flow diafiltration for ADC formulation.

Burlington, MA, US

• Invented a novel, centrifugal downstream processing device for cell therapy manufacturing.
• Developed an operable cell retention filter compatible with immunotherapeutic cells.
• Modeled downstream processing steps to predict performance based on FDA and industry guidelines for final product fill/finish.
• Led technology scouting efforts to support collaborations and provided guidance to the venture capital arm of Merck, KGaA, Darmstadt, Germany.
• Reduced overall process of expanding therapeutic cells within bioreactors by an entire step by investigating parameters previously unexplored in the field.
• Scripted and automated image analyzer for the detection of defects in downstream filters.

• Developed an algorithm to calculate blood hemoglobin levels in a patient based on in vivo spectroscopic data acquired non-invasively.
• Prototyped novel medical device.
• Designed clinical experimental protocol from a statistical basis.

Boston, MA, US

Designed a novel electrotactic device, taking the project from concept to validation, which has led to filing for a patent.Reduced processing time of cell tracking by 80% by creating label-free image analysis algorithms to automate the tracking of clustered epithelial cells.Developed numerous image processing algorithms used by the entire Cell Engineering.

Boston, MA, US

Ran labs, held office hours, graded, and helped write exams for BIOE 2366: Bioengineering Instrumentation, Measurement and Imaging.

Boston, MA, US

Held office hours including recitations, taught during occasional lecture hours, graded, and helped write exams for CHME 3312: Transport Processes 2 and Separations.

Lowell, MA, US

Researched electrical properties conducting polymers, namely polyaniline. Investigated the hydrophobic and hydrophilic surface properties of polymers textured at the nanoscale.Developed biological and chemical sensors with conducting polymers and electronic materials such as carbon nanotubes.

Doctor Of Philosophy (Ph.D.), Chemical Engineering

Bse, Chemical Engineering, Nanomaterials Engineering