Vincent Lemaire

Vincent Lemaire Email and Phone Number

Driven by impact and innovation | Systems modeling | AI | Currently working on immunotherapy combinations at Genentech @ Genentech
Vincent Lemaire's Location
South San Francisco, California, United States, United States
Vincent Lemaire's Contact Details

Vincent Lemaire personal email

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About Vincent Lemaire

I have a PhD in Physics with a solid background in dynamical systems theory and biomathematics. My mathematical strengths are differential equations (ODE, DDE, and PDE) and optimization problems. I specialize in mathematical modeling of biological regulatory systems and disease dynamics with a particular interest in tracking down therapeutic strategies (e.g. osteoporosis, diabetes). I have +8 years of experience in mathematical modeling and simulation in the pharmaceutical industry. I am currently working at Pfizer in the San Francisco Bay area. My role is to use mathematical modeling and understanding of biology to aid in generation and optimization of antibody-based therapeutics in various disease areas. The scope of the work goes from early identification of appropriate biological targets to prediction of clinical outcomes. Before that, at Labopharm, I was responsible of a small team made up of interns and collaborators from other departments. The problems we had been working on include mechanistic PK/PD modeling with the objective of improving both the formulation of the drug products and the clinical development strategy. During my postdoctoral experience, I assembled and led a multidisciplinary team of international researchers to work on the activation of human gene transcription. Together, we proposed new experimental avenues based on mathematical analysis of physical models of transcription. My goal is to continue unraveling biological regulatory processes within an integrated multidisciplinary team. I am particularly interested in how biological dysfunctions may be reversed using insights from mathematical modeling and experiments.Specialties: Mathematical modeling and simulation of biological regulatory processes.Dynamical systems. Scientific computing.Domains of application: physiology, cell biology, biochemistry, signalling networks, therapeutic strategies, pharmacokinetics, pharmacodynamics, target discovery, drug effect mechanisms, drug release, drug delivery.

Vincent Lemaire's Current Company Details
Genentech

Genentech

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Driven by impact and innovation | Systems modeling | AI | Currently working on immunotherapy combinations at Genentech
Vincent Lemaire Work Experience Details
  • Genentech
    Distinguished Scientist, Clinical Pharmacology, Systems Modeling Lead
    Genentech Oct 2022 - Present
    South San Francisco, California, Us
  • Genentech
    Senior Principal Scientist, Clinical Pharmacology, Systems Modeling Lead
    Genentech May 2021 - Sep 2022
    South San Francisco, California, Us
  • Genentech
    Principal Scientist, Clinical Pharmacology, Systems Modeling Lead
    Genentech Jul 2020 - Apr 2021
    South San Francisco, California, Us
  • Genentech
    Senior Scientist, Clinical Pharmacology, Systems Modeling Lead
    Genentech Feb 2016 - Jun 2020
    South San Francisco, California, Us
    The role is to use quantitative methods to help in the early clinical development of therapeutics, mostly in immuno-oncology, but not only. This inlcudes checkpoint inhibitors antibodies and T-cell-engaging bispecific antibodies, used as single agents or in combination. The methodology relies on quantitative systems pharmacology (QSP), mechanisms-based modeling, disease and pathway modeling, PKPD modeling, or any other approach that will help answer our questions of interest with speed and reliability. The focus is on questions regarding human dose selection, biomaker identification, and categories of patients, but also spans from pre-clinical research to late stage clinical development. The role is also to identify therapeutic indications and modalities for which the use of systems modeling would have the most impact in the advancement of the pipeline.
  • Pfizer
    Principal Scientist - Mathematical Modeler
    Pfizer Aug 2011 - Jan 2016
    New York, New York, Us
    As part of the Applied Quantitative Genotherapeutics group, my role is to use mathematical modeling and understanding of biology to aid in the development and optimization of antibody-based therapeutics (including mAb, ADC and T cell engaging bispecific) in various disease areas, mainly oncology and immuno-oncology. The scope of the work goes from early identification of appropriate biological targets to prediction of clinical outcomes.
  • Labopharm Inc.
    Research Scientist
    Labopharm Inc. Aug 2006 - Jul 2011
    Biopharmaceutical modeling and simulation.Optimization of drug disposition of controlled-release forms.Pharmacokinetic modeling.Biopharmaceutical Assessment and Feasibility.
  • Institut Des Hautes Études Scientifiques (Ihes)
    Visiting Fellow
    Institut Des Hautes Études Scientifiques (Ihes) Jan 2006 - Feb 2006
    Developped models of transcription activation in eukaryotes
  • Mcgill University
    Postdoctoral Researcher
    Mcgill University Jan 2004 - Dec 2005
    Montreal, Qc, Ca
    Mathematical modeling of the activation of gene transcriptionin human, and of the dynamics of chromatin structure. Assembled and led an international multidisciplinary team on the project.
  • Université De Montréal
    Phd Student
    Université De Montréal 1998 - 2003
    Montréal, Qc, Ca
    Biophysics, biomathematics, computational biology. Applications in molecular and cellular biology, and physiology.
  • Smithkline Beecham
    Modeling Scientist (Coop Position)
    Smithkline Beecham Jan 2000 - Dec 2000
    Brentford, Middlesex, Gb
    Developed and analyzed mathematical models of osteoporosis. Model-induced therapeutic strategies.

Vincent Lemaire Skills

Computational Biology Mathematical Modeling Pharmacokinetics Biochemistry Pharmaceutical Industry Data Analysis Statistics Scientific Computing Matlab Drug Delivery Simulations Drug Discovery Bioinformatics Clinical Trials Biological Systems Drug Development Differential Equations Dynamical Systems Pharmacodynamics Systems Biology Modeling Of Biological Systems Biomathematics Mathematica Stochastic Methods Biopharmaceuticals Optimization Formulation Mechanistic Pk/pd Modeling Global Optimization Problems Data Integration Statistical Analysis Stability Analysis Bifurcation Analysis Stochastic Simulations Image Processing And Analysis Perl Python

Vincent Lemaire Education Details

  • Mcgill University
    Mcgill University
    Physics
  • Université De Montréal
    Université De Montréal
    Physics
  • Université Côte D'Azur
    Université Côte D'Azur
    Turbulence Et Systèmes Dynamiques

Frequently Asked Questions about Vincent Lemaire

What company does Vincent Lemaire work for?

Vincent Lemaire works for Genentech

What is Vincent Lemaire's role at the current company?

Vincent Lemaire's current role is Driven by impact and innovation | Systems modeling | AI | Currently working on immunotherapy combinations at Genentech.

What is Vincent Lemaire's email address?

Vincent Lemaire's email address is vi****@****ail.com

What is Vincent Lemaire's direct phone number?

Vincent Lemaire's direct phone number is +121257*****

What schools did Vincent Lemaire attend?

Vincent Lemaire attended Mcgill University, Université De Montréal, Université Côte D'azur.

What skills is Vincent Lemaire known for?

Vincent Lemaire has skills like Computational Biology, Mathematical Modeling, Pharmacokinetics, Biochemistry, Pharmaceutical Industry, Data Analysis, Statistics, Scientific Computing, Matlab, Drug Delivery, Simulations, Drug Discovery.

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