 Lead a research team for study the mechanism of anemia and RBC-transfusion associated systemic inflammatory response syndrome (SIRS) in preterm neonates Developed a novel murine model of RBC-transfusion associated gut mucosal injury Establish research collaborations across scientific teams and neonatologists

 Lead the project for identification and comparison of gene(s) regulation and microarray analysis in intestine of inflammatory gut from human and mice model Identified/demonstrated microRNA let-7e-5p is critical regulator for intestinal tight junctions integrity and microtubules assembly, silencing by in-vitro and in-vivo could potential therapeutic in anemic neonates Establish ex vivo intestinal organoid culture system to investigate the effects of anemia on alteration of intestinal barrier function and their cytoskeletal changes

 Successfully developed in vivo TNBS-induced Necrotizing Enterocolitis murine model for investigate the role of macrophage in mechanism(s) of gut mucosal inflammation Screened and evaluated cytokines and growth factors in developing intestine and studied their role(s) in neonatal gut inflammation Identified that smad7 interrupts TGF-β signaling in intestinal macrophages and promotes inflammatory activation of these cells during Necrotizing enterocolitis

 Established that epithelial apoptosis is an early event that precedes villous damage during Extracorporeal Membrane Oxygenation (ECMO) in piglet model Identified the CXCR2-CXCL5 axis involved in the recruitment of macrophage infiltrate in inflamed intestine and successfully blocked the migration of these cells that reduce the injury

 Successfully generated murine antibodies for IL-17a and IL-23 using vector based technology and tested for their potential therapeutic purposes in hepatocellular carcinoma