Meng (Mona) Jiao Email & Phone Number

Waltham, Massachusetts, United States

Raleigh-Durham, North Carolina Area

• Translational research on target discovery and development
• Identified a target through genome-wide CRISPR screening to potentiate immune checkpoint blockade (ICB) therapy; Unraveled the intrinsic and acquired mechanisms of mutation-mediated lung tumor resistance to ICB.
• Tested compound combinations and developed a targeted therapy to enhance glioma sensitivity to radiotherapy; Revealed unique tumor signaling and immune responses to drug treatments by next-generation sequencing and.
• Drove in-depth computational analysis of clinical data from various cohorts. Identified a target and a subsequent pro-inflammatory pathway that boosts anti-tumor immunity (iScience 2024)--Collaboration and project.
• Fostered cross-functional collaborations with core facility staff, data scientists, and clinicians to provide translational insights into patient stratification and drive the development of targeted and combination.
• Collaborated with the legal team on patent filing and the legal contract office to access clinical data.

Greater New York City Area

• Led mechanistic studies to identify signaling pathways crucial for cancer invasion.
• Established cell reprogramming with genetic modification, mechanical stress, and drug treatments.
• Built a 3D culture model to study mesenchymal-to-amoeboid transition (MAT) for cancer metastasis and traced cell transition via live-cell imaging and fluorescent microscopy.
• Conducted cell/non-cell-based assays to determine protein-protein interactions, protein binding sites, and binding affinity.
• Adopted CRISPR/Cas9 when just developed to generate knockout cells for functional analysis.

New York City Metropolitan Area

- Mentored three graduate/undergraduate students with experimental design, data analysis, and troubleshooting for cell cycle and cell migration studies. - Developed cell-based assays and determined the roles of target protein in cell plasticity and breast cancer metastasis.

Greater New York City Area

-Taught over 200 pre-med students and guided practical lab activities in Introductory Biology I lab (BISC 1413) and Introductory Biology II lab (BISC 1414).

Greater New York City Area

- Designed and generated plasmids encoding target genes and studied the impact of juvenile hormone (JH) signaling in drosophila metamorphosis. - Predicted and identified regulatory elements (RE) upstream of target genes with computational protein alignments toolkit and determined conserved RE sites that maintain normal metamorphosis.

Beijing City, China

- Identified the critical sites of target protein for dimerization in leukocyte recruitment and activation. - Determined the metabolic responses of engineered leukocytes by HPLC-MS.

Beijing City, China

- Contributed to large-scale antibody production and characterization. - Performed serum preparation, and antigenicity tests using immunoassays (i.e. serum bactericidal assays, ELISA).

Doctor Of Philosophy (Ph.D.), Cell/Cellular And Molecular Biology; Cancer Biology

Bachelor’S Degree, Biotechnology