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Monique Howard is listed as PRINCIPAL CONSULTANT AND FOUNDER at Northwest Biosensor Consulting, LLC, based in Seattle, Washington, United States. AeroLeads shows a work email signal at msn.com and a matched LinkedIn profile for Monique Howard.
Monique Howard previously worked as Scientist at Amgen and Senior Associate Scientist at Amgen. Monique Howard holds Bs, Biology from Gonzaga University.
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I am a highly motivated and experienced analytical/ biophysical scientist and have worked in the Seattle area in both academic institutions and biotechnology companies. I have primarily worked in the biotech industry where I have accumulated a broad knowledge base in drug discovery and drug development. I started my biotech career at what was then a small startup company, ICOS, and for the past 8 years I have worked at one of the largest biotech companies, Amgen. Out of these experiences, I have gained a unique perspective of the drug discovery and development process for both large-molecule biologics and small-molecule therapeutics. Success for me has come by being flexible, nimble to learning new technology. I enjoy the process of understanding and improving technology, but better yet, I enjoy applying technology in a meaningful way to a scientific question that ultimately produces insightful and impactful results. I am well organized and detailed oriented, but I do not lose sight of the overall goals. I also understand that for results to be impactful they need to be understood, so I take great care in communicating my results in well written technical reports as well as clearly delivered meeting and seminar presentations.Being a part of the biotech industry in Seattle has been very rewarding for me. I have had the good fortune of collaborating with many innovative scientists while contributing, in a meaningful way, to the development of a variety of novel therapeutics that have or will better the lives of patients.Participating Author on 11 publications and Author of 3 PatentsBiophysics, Biomolecular Interactions, Drug Metabolism, Drug Discovery, Drug Development, Bioengineering, Pharmaceutics, Biotechnology, Protein Chemistry, Assay Development,Biochemistry, Cell Culture, Monoclonal Antibodies, HPLC, Mass Spectrometry, Molecular Biology,Bioanalysis, High Throughput Screening, Pharmacokinetics
Listed skills include Writing, Primates, Consulting, Clinical Trials, and 285 others.
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Consulting service for biomolecular interaction studies using biosensor technology for the academic and biotechnology industry including assay development, study design, data analysis, and regulatory reporting.
Thousand Oaks, Ca, Us
Supported the pipeline by determining the kinetic and equilibrium binding properties of protein/protein interactions using Surface Plasmon Resonance (Biacore / ProteOn) and KinExA technology, simultaneously carrying out studies over a diverse set of projects from Biosimilars and late stage clinical molecules to early discovery molecules. Results were communicated through detailed reports and cross-site presentations.Developed biosimilar comparability studies to assess target binding kinetics for several biosimilar projects which included assay development, implementation and regulatory report writing and documentation all performed in the spirit of GLP. Developed a best practices approach for the analysis and reporting of high affinity interaction for the regulatory environment including a cross platform SPR evaluation.Developed high content, high throughput SPR screens for large panels of engineered antibodies to assess target binding and antibody attributes such as modifications for improved PK and manufacturability.Supported the next generation protein platforms with innovative binding studies which included antibody drug conjugates (ADC), bispecific Abs, pH responsive Abs and bispecific T cell engager (BiTE®) antibodies.Designed experiments to understand the mechanism of action for a class of pH responsive antibodies designed to modulate the PK/PD response.Supported Amgen intellectual property with biomolecular interaction studies and co-authored patent describing the screening and selection of a class of pH responsive antibodies.Supported technology development by designing and implementing studies to evaluate the use and limitations of a variety of binding technology platforms. Served in a leadership role as the Biologics department representative for a cross functional project team coordinating cloning, expression, purification, and analytics of recombinant proteins across multiple Amgen sites.
Thousand Oaks, Ca, Us
Developed and implemented definitive small-molecule plasma protein binding and blood partitioning studies for investigational new drug (IND) applications. Authored the related agency reports and documentation to support Amgen small-molecule filings. Performed CYP450 induction assays using cryopreserved hepatocytes monitoring protein levels by enzyme activity with isoform specific probe substrates and LC/MS detection and monitoring mRNA levels using RT PCR.Developed liquid chromatography mass spectrometry (LC/MS) detection methods to measure discovery small-molecules in complex biological matrixes and performed pharmacokinetic modeling using WinNoNlin.Supported small-molecule bioanalytical formulation studies in a GLP setting using Watson laboratory information management systems (LIMS).
Us
Managed small-molecule CYP450 inhibition studies in support of lead optimization of new chemical entities (NCE) for drug discovery and small-molecule development candidates. Supervised two direct reports supporting CYP450 assays. Responsible for hiring, training, skills development and compensation linked performance appraisals.Analyzed structure activity relationships of small-molecules with respect to CYP450 inhibition for drug discovery projects. Participated in the selection of small-molecule drug candidates providing risk management assessments for integrated ADME team, lead biologists, chemists and upper management. Initiated and managed outsourcing contracts for CYP450 inhibitions assays for lead development candidates and provided comprehensive reports for licensing and partnering of in-house projects for business development.Designed and implemented an investigational toxicology study to determine CYP450 inhibition profiles for a small-molecule development compound using multiple API lots.
Us
Designed and implemented the isolation and characterization of product-related substances for a Phase III clinical biologic in support of a potential BLA filing. Worked as part of a team of two scientist and two research associates with joint supervision of one research associate.Optimized analytical reversed-phase HPLC method used as a release assay for Phase III biologic.Developed a thin layer chromatography assay to separate lipids from Phase II clinical trial patient samples. Performed lipoprotein-binding assays for comparability studies of Phase III biologic to support a change in manufacturing and formulation of product.Discovery biologist/ biochemist– Research Oncology DepartmentDeveloped and implemented a high throughput small-molecule screen for a cell cycle dependent kinase leading to the discovery of the lead chemical series. Developed an automated IC50 assay to test inhibitor potency. Screened for kinase selectivity using a panel of in-house developed assays.Developed chemo- and radio-sensitization assays using a variety of chemotherapeutic agents and cancer cell lines monitoring cell growth by tritiated thymidine incorporation. Monitored for cell cycle arrest within cultured cells using propidium iodine staining and FACS analysis.
Us
Discovery yeast and molecular biologistInvestigated A-kinase Anchoring Proteins (AKAP) and their association with modifying enzymes responsible for the potentiation of cAMP dependant pathways. Discovered the interaction between AKAP79 and protein phosphatase 2B and the regulatory subunit RI of protein kinase A using the yeast two hybrid system leading to the issuing of two patents.
Us
Molecular biologist Successfully developed cDNA libraries for the purpose of cloning human phosphodiesterase genes. Developed a variety of molecular assays including RNase protection assays and Northern blots to determine the tissue localization of phosphodiesterase isoforms. Constructed a variety of plasmid constructs for the expression of PDE isoforms in E. coli.
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Monique Howard works for Northwest Biosensor Consulting, LLC.
Monique Howard is listed as PRINCIPAL CONSULTANT AND FOUNDER at Northwest Biosensor Consulting, LLC.
AeroLeads has found 1 work email signal at @msn.com for Monique Howard at Northwest Biosensor Consulting, LLC.
Monique Howard is based in Seattle, Washington, United States while working with Northwest Biosensor Consulting, LLC.
Monique Howard has worked for Northwest Biosensor Consulting, Llc, Amgen, and Icos.
You can use AeroLeads to view verified contact signals for Monique Howard at Northwest Biosensor Consulting, LLC, including work email, phone, and LinkedIn data when available.
Monique Howard holds Bs, Biology from Gonzaga University.
Monique Howard is listed with skills including Writing, Primates, Consulting, Clinical Trials, Screening, Chemical, Tlc, and Limitations.
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