Michael Killoran Email & Phone Number

Madison, Wisconsin Area

Protein Engineering • Directed Evolution of Enzymes and Macromolecules • Automation for High-throughput Screening • Machine Learning • Bioinformatics • Data Science

Madison, Wi

Bioinformatic algorithms for rapid assay design • Isothermal assay development for nucleic acid and protein-based diagnostics • Microfluidic device design and engineering • Point-of-care medical device commercialization.

Drug discovery lead in high-throughput assay design and implementation • Protein expression and solubility optimization for manufacturing • Isothermal nucleic acid and enzyme-driven assay development.

Technical lead in engineering and characterization of proteins from numerous families • Engineered recombinant proteins for increased thermostability and performance using data mining algorithms and directed evolution screening • Oversaw manufacturing-scale production and validation testing of enzymes for clinical diagnostic assays • Programmed bioinformatic algorithms for DNA/RNA sequence recognition and performance prediction in molecular assays. • Experience with Polymerases, Reverse Transcriptases, Nucleases, Proteases, Restriction Enzymes, Lysins, Fabs, and Monoclonal Antibodies.

Adaptation of small molecule labeling technologies for cross-platform protein labeling and detection • Large-scale genetic screening methods for identifying site-specific protein interactions in microbial cells. • Experience with chemical modification enzymes, reporter-fusions, and structure-specific binding proteins.

Determined the high-resolution x-ray crystal structures of several DNA metabolism proteins • Used biophysical, chemical proteomic, and biochemical methods to dissect the molecular functions of multiple DNA repair enzymes • Successfully led a cross-functional team effort to elucidate a key mechanism of bacterial pathogenesis. • Experience with Helicases, DNA-binding proteins, Proteases, and Recombinases.

Developed new molecular diagnostic markers to map genetic changes among plant species distributed globally by ocean currents.

Ph.D., Biomolecular Chemistry

Activities and Societies: Co-chair of the Student-Faculty Liaison Committee for the Department of Biomolecular Chemistry

Specialized Certificate, Clinical Trials Administration

B.S., Magna Cum Laude, Biology

Activities and Societies: 2001 Big South Conference Scholar-Athlete of the Year, Team Captain - Men's Cross Country and Track and Field.