In the most recent position, I have been establishing and optimizing high-level mesoporous silica nanoparticles (LP-MSNs) for improved cancer immunotherapy. I examine in vitro and in vivo safety of neoantigen-conjugated LP-MSNs and their specific immune-stimulation.List of My Key Contributions: ★ Synthesized and optimization of MSNs and conjugation of neo-antigens to LP-MSNs. ★ Designed novel high-capacity nanomaterials for immunotherapy of cancer.

In my previous role as graduate research assistant, I developed nanoparticle-based therapeutic and imaging modalities for pancreatic cancer and breast cancer. I established novel targeted stimuli-responsive nanoparticles for co-delivery of Gemcitabine and cisplatin, MSN-based platform for delivery of tumor stroma-modifying agents, having an amazing therapeutic performance in pancreatic cancer mouse models. I designed and made sub-20 nm MSNs as a potential multi-functional nanoprobe for early diagnosis of PDAC and other cancersSome of My Key Contributions: ✪ Designed and investigated nanoparticle-based sequential therapy in multi-targeting of cancer cells and cancer stem-cells for improved triple negative breast cancer therapy.✪ Structured and enhanced dual-targeted MSNs for transport across BBB using 3D microfluidics BBB model. ✪ Executed in vitro and in vivo targeting and therapeutic efficacy analysis in panel of cancer cells, syngeneic, and transgenic mouse models. ✪ Improved high-capacity and pore-size tunable MSNs for multi-functions delivery of drugs, peptides, and nucleic acid agents.

Graduate Teaching Assistant, NANO 8060-Nanomedicine Designed and delivered lectures for the graduate-level course, Cancer hallmarks, Tumor microenvironment, immuno-oncology, and cancer immunotherapy, nanomedicine applications in cancer diagnosis and therapy.

In this role as a research assistant, I have characterized the physiochemical properties of chemical-mechanical planarization (CMP)-based nanoparticles and extensively studied their interaction with lung cells.Some of My Key Contributions are: ◆ Categorized nanoparticles used in CMP process and examined cellular interaction, uptake, and cytotoxicity. ◆ In vivo study of cardiac repolarization as a tool for the non-invasive assessment of cardiovascular system exposure to carbon nanotubes and ceria nanoparticles