Mukesh Kumar, Ms (Pharm), Ph.D. Email & Phone Number

Cambridge, England, United Kingdom

Hong Kong Sar

Research area: Development of a novel class of anti-allergic drugs for chronic skin inflammatory conditions• Leading translation projects, developing MRGPRX2 antagonists as novel drugs for treating chronic skin inflammatory conditions such as atopic dermatitis, chronic urticaria and rosacea. • Developed mice model of atopic dermatitis, chronic urticaria and rosacea• Developing in vitro co-culture disease model using mast cells, keratinocytes and macrophages• Chronic spontaneous… Show more Research area: Development of a novel class of anti-allergic drugs for chronic skin inflammatory conditions• Leading translation projects, developing MRGPRX2 antagonists as novel drugs for treating chronic skin inflammatory conditions such as atopic dermatitis, chronic urticaria and rosacea. • Developed mice model of atopic dermatitis, chronic urticaria and rosacea• Developing in vitro co-culture disease model using mast cells, keratinocytes and macrophages• Chronic spontaneous urticaria (CSU) patients' blood sample handling, peripheral blood mononuclear cells (PBMCs) isolation and culture • Experienced in PBMCs and basophil isolation and processing for ELISA, cytokine membrane array, western blot, flow cytometry and qPCR analysis • Leading a team of research assistants, PhD students and Undergraduates. Managing the entire project, including planning, coordination, meetings, and milestone achievement Show less

Hong Kong Sar

Research area: Pharmacodynamics study of small molecule antagonists for the treatment of allergies, itch and inflammation• Published research papers and prepared research proposals for internal and external funding• Collaborated with clinician and immunologist to work on chronic urticaria patient's blood samples• Developed mice models of itch • Mentored PhD students, research assistants, summer students and undergraduate students

Hong Kong

•Development of novel small molecule antagonists for MRGPRX2 (GPCR)•Identified and validated a lead molecule for the development of novel MRGPRX2 antagonists•Generated novel small molecule library based on the pharmacophore of lead molecules•Collaborated with the technology transfer office, HKU and submitted one US patent from our innovation•Received funding from HKU research grant committee (>200,000 HKD)

Hong Kong Sar

•Molecular Biology course for B.Sc. students, HKU•Plant & Food Biotechnology course for B.Sc. students, HKU•Received the Certificate of Teaching and Learning in Higher Education from Center for the Enhancement of Teaching and Learning, HKU•Conducted wet laboratory experiments such as gene cloning, transformation, histology, immunohistochemistry, in situ hybridization, triparental mating, DNA isolation, and Agrobacterium-mediated transformation•Prepared lab report guidelines… Show more •Molecular Biology course for B.Sc. students, HKU•Plant & Food Biotechnology course for B.Sc. students, HKU•Received the Certificate of Teaching and Learning in Higher Education from Center for the Enhancement of Teaching and Learning, HKU•Conducted wet laboratory experiments such as gene cloning, transformation, histology, immunohistochemistry, in situ hybridization, triparental mating, DNA isolation, and Agrobacterium-mediated transformation•Prepared lab report guidelines, marking schemes, and manual videos and guided students for experiments, lab report writing, poster preparation, and presentation•Mentored and supervised summer research students and final-year B.Sc. project students Show less

Hong Kong Sar

Graduate House, HKU• Pastoral care team member•Assisted the Master in the House's general administration, maintaining the moral, social, and general well-being of all postgraduate residents•Organised fitness and mental health workshops for more than 180 residents

Varanasi Area, India

•Worked as a research fellow and teaching assistant in the Department of Pharmaceutical Engineering and Technology for an undergraduate Pharmacology course(earlier Department of Pharmaceutics).•Developed animal model of chronic unpredictable stress, myocardial infarction, and type 2 diabetes mellitus•Validated three-lead ECG recording, behavioural and biochemical markers assessment in mice and rats•Worked as a student editor of journal "The Pharmstudent" (EISSN: 2347-6001, ISSN:… Show more •Worked as a research fellow and teaching assistant in the Department of Pharmaceutical Engineering and Technology for an undergraduate Pharmacology course(earlier Department of Pharmaceutics).•Developed animal model of chronic unpredictable stress, myocardial infarction, and type 2 diabetes mellitus•Validated three-lead ECG recording, behavioural and biochemical markers assessment in mice and rats•Worked as a student editor of journal "The Pharmstudent" (EISSN: 2347-6001, ISSN: 0379-556X, an official journal of pharmaceutical society of Department of Pharmaceutics). Show less

Guwahati Area, India

•Accomplished research project on Evaluation of the Effects of Quercetin and Baicalein on Isoproterenol-induced myocardial infarction in Male Wistar Rats.•Published a review article titled Animal Models of Myocardial Infarction: Mainstay In Clinical Translation in the Regulatory Toxicology and Pharmacology (Elsevier).•Some subsequent projects were as follows:a) Cardiovascular Disease Prevalence and Drug Utilization Patterns at A Tertiary Care Hospital in Northeastern India, a… Show more •Accomplished research project on Evaluation of the Effects of Quercetin and Baicalein on Isoproterenol-induced myocardial infarction in Male Wistar Rats.•Published a review article titled Animal Models of Myocardial Infarction: Mainstay In Clinical Translation in the Regulatory Toxicology and Pharmacology (Elsevier).•Some subsequent projects were as follows:a) Cardiovascular Disease Prevalence and Drug Utilization Patterns at A Tertiary Care Hospital in Northeastern India, a 3-month drug utilization study.b) Evaluation of Chemopreventive effect of chrysin, a dietary flavone against benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice.c) Evaluation of nephroprotective potential of Hesperetin against Cisplatin-Induced Nephrotoxicity in Male Wistar Rats d) Evaluate the protective effect of Nordihydroguaiaretic acid (NDGA) on cisplatin-induced genotoxicity and nephrotoxicity by attenuating oxidative stress in Swiss albino mice•Published all the research findings in internationally reputed journals like Inflammation Research, Journal of Biochemical and Molecular Toxicology, Pharmacological Reports, etc,.•Well-trained to conduct experimental design, animal studies, rodent model development, and molecular analysis experiments using Western blot, ELISA and other bioassays for proteins and RNA extraction, RT-PCR for gene expression. Show less

Ranikhet, Almora Uttrakhand

•Completed 500 hrs clinical training from the pharmacy council of India recognized State Govt. Hospital Ranikhet•Learned prescription reading, drug dispensing, stock register maintenance, •Trained in first aid, emergency medication and drug administration via different routes such as intravenous, intramuscular and subcutaneous. •Registered as a Pharmacist in the state pharmacy council of India.

Doctor Of Philosophy - Phd, Novel Antagonist Developmnet For Gpcrs

Activities and Societies: People choice award for 3MT thesis competition, HKU Member of Biological sciences student association (BGSA).

Master Of Science (Ms), Pharmacology And Toxicology, 10 Cgpa

Activities and Societies: 1. During this period I published one review and four research papers in international SCI indexed journals. 2..

(Sbs Pgi Balawala, Dehradun) Bachelor'S Degree (University Gold Medal), Pharmacy, First Class With Honour

Activities and Societies: 1. Secured All India Rank 345 in National Institute of Pharmaceutical Education and Research Joint Entrance Exam.

Diploma, Pharmacy, 82 %

Activities and Societies: 1) Served as a Volunteer and Pharmacist in several Medical camps and Eye surgery camps organized by Yogoda.