Venkata Sasidhar Manda Email & Phone Number

Hyderabad, In

Hyderabad, Telangana, India

Hyderabad, Telangana, India

As the Founder of a pioneering startup, I lead the development of cutting-edge exosomal diagnostics tailored for the early detection and management of neurodegenerative diseases. Our proprietary platform leverages advanced exosome profiling to identify biomarkers from blood and saliva, enabling non-invasive diagnostics for Alzheimer's, Parkinson's, and other neurodegenerative conditions.We are also advancing the productization of lab-developed tests into microfluidic assays, enhancing accessibility and scalability. Additionally, we are at the forefront of creating digital twins for neurodegenerative diseases, providing a revolutionary tool for personalized diagnostics and treatment pathways.I oversee all aspects of the business, from research and development to clinical validation and regulatory submissions, while working closely with hospitals, academic institutions, and pharmaceutical companies. Our mission is to transform neurodiagnostics through accessible, precise solutions, shaping the future of personalized medicine.

Hyderabad Area, India

Development of CNS diagnostics and therapeutics using exosome profiling and ocular biomarkers. Portfolio includes Alzheimer disease, Multiple Sclerosis, Stroke and Parkinsons.

Hyderabad

Established exosomal platform (EP), and spearheading the development of associated technologies including, biomarkers, drug delivery technology, and therapeutics.Establish clinical biomarker development programs, validation, ensuring alignment with project development plan.Responsible for implementation of interdisciplinary aspects of precision medicine, including biomarkers, correlative science, and personalized medicine.Manages to interface with clinics and genetic service providers for identification and execution of correlative science studies.Develops standard processes for patient selection, stratification, pharmacodynamics and correlative studies for trials by working with internal and external, stakeholders. Partners with the Clinical leadership to identify and validate external companies for, companion diagnostic development and personalized medicine companies.Collection and maintenance of bio-bank samples for assay discovery and validation across multiple disease areas as a part of the CDx development strategy.Evaluate external clinical centers, implement, foster communication, and collaboration with clinical and academic communities to support clinical strategies.

Hyderabad

Evaluate external clinical centers, implement, foster communication, and collaboration with the clinical and academic communities.

Los Angeles, Usa.

• Discovered roles of new inflammatory genes (IL13RA2, CD40Ligand, and TLR7) and their associated mechanisms in Multiple Sclerosis (MS) and lupus. • Successfully handled and coauthored four translational biology projects involving estradiol and Glucocorticoids in EAE.• Developed expertise in animal model of Multiple sclerosis, Lupus and Autism for conducting translational research

Hyderabad Area, India

Technical due diligence studies for method development of diagnostic kits

Hyderabad Area, India

• Liaise with project stakeholders on an ongoing basis to ensure timely and cost effective delivery on in QC projects • Conducted technology transfer in areas of Quality control and Quality assurance of rhGMCSF.• Compilation of regulatory dossiers for market authorization of biosimilars with the Department of Biotechnology and Environmental clearance with Department of Environment, India.

Hyderabad Area, India

• In process testing of Snake venom antiserum• R&D work involved establishment of pilot scale fermentation parameters for extraction of Hyaluronic acid from Streptococcus zooepidemicus

Master thesis - Signal Transduction pathways

Phd, Pharmaceutical Biotechnology

M.Sc; Distinction, Biotechnology

B.Sc; Distinction, Biochemistry

Icse