Muhammad Myn Uddin, Phd Email & Phone Number

Sunnyvale, Ca, Us

San Jose, California, United States

Key Responsibilities & Contribution: #Lead multiple projects in the cell and gene therapy (CGT) space, driving innovation and development.#Actively work with various teams within R&D and across departments, including market strategy, marketing, operations, quality control (QC), quality assurance (QA), and contract research organizations (CROs), to drive projects from inception to launch.#Play a key role in developing tools and products throughout different phases of product development, including proof of concept (PoC), research, development, and product release.#Engage vigorously with key opinion leaders (KOLs) in the cell therapy field and collaborate with academic and industrial labs to foster innovation and research.#Actively contribute to the strategic decisions of the company to bring new products to market, aligning research goals with business objectives.#Contributed to the development of a new transduction tool based on microfluidics technology, enhancing transduction efficiency and precision.#Developed an in-house natural killer (NK) cell culture and transduction system, optimizing protocols for enhanced therapeutic applications.#Established Oxford Nanopore sequencing for the analysis of AAV viral genomes, facilitating improved understanding of viral characteristics.

Calgary, Canada Area

Major Research Contributions:#Led multiple projects testing novel biologics (peptide-MHC conjugates to nanoparticles) in preclinical settings (both in vitro and in vivo), including pharmacokinetics and pharmacodynamics for autoimmune diseases.#Investigated and identified key molecules involved in TR-1 cell formation using multi-omic approaches, including: Analysis of WT/cKO mice, sc/bulk RNA sequencing, CyTOF & other advanced molecular biology techniques.#Routinely Injected pMHC-NPs into various mouse backgrounds (NOD, B6, BALBc, SPF & GF) using different administration routes (IP, IV, IM) and analyzed mice for PK/PD.#Developed assays to monitor biologic payloads with fluorescence in different organs (blood, liver, spleen, lung, lymph nodes, bone marrow) at various time points (GF conjugate to protein analyzed by FACS) for PK. #Established in various in vitro functional assays (killing assay, cytokine assay, ALT, immune response assay, etc)#Established asthma models in mice and protocols to isolate bronchoalveolar lavage (BAL); conducted live mouse lung functional tests using FlexiVent from SCIREQ.#Established various autoimmune disease models, including colitis, experimental autoimmune encephalomyelitis (EAE), and liver autoimmune diseases (AIH, PBC).#Designed and produced stable CHO-cell lines to produce secretory proteins (peptide-MHC).#Produced proteins on a large scale using fed-batch production and purified them (TFF and FPLC) for conjugation to nanoparticles.#Actively collaborated with the chemistry team for PEG-mediated conjugation of proteins with nanoparticles.#Supervised undergraduate and PhD students and technicians, fostering their development and research skills.# Supported to write manuscript and research grant application.#Managed projects in a highly collaborative environment, partnering with academic and industry collaborators to translate research findings into clinical applications.

Japan

Major Research Contributions: #Led multiple projects to screen anti-inflammatory compounds targeting inflammasome pathways in macrophages using both in vitro and in vivo models.# Actively collaborated with pharmaceutical companies to screen their compound libraries to inhibit inflammation #Developed in vitro assays to test the efficacy of selected compounds #Developed in vivo mouse models for inflammatory diseases (lung, liver, and peritonitis) and tested the efficacy of selected compounds.#Tested pharmacokinetics (PK) and pharmacodynamics (PD) of selected compounds in mouse models.#Supervised undergraduate summer and master’s students.#Received a competitive JSPS research grant as a co-investigator for 2.5 million yen.#Presented research at local and international conferences.

Chittagong, Bangladesh

Major Responsibilities: #Designed and instructed undergraduate and graduate courses in Immunology and Advanced Immunology.#Conducted research on compounds targeting multidrug-resistant pathogens across various diseases.#Supervised research projects for graduate and undergraduate students.#Menotred students pursuing higher studies abroad including the USA.

Tokushima, Tokushima, Japan

Major Research Contributions:#Led multiple projects to investigate the molecular mechanisms of CD8+ T cell development.# Designed and cloned lentiviral and retroviral vectors to express over 10 different proteins in vitro.#Established various assays, including reporter assays, ChIP assays, and functional assays for immune cells.#Generated knockout mice using CRISPR/Cas9 technology within six months.#Supervised the research work of six undergraduate and graduate students.# Wrote manuscripts and provided support for grant writing initiatives.#Developed protocols for multicolor flow cytometry, confocal microscopy analysis of tissues, Western blotting, qPCR, and tissue sectioning.

Chattogram, Bangladesh

Key Responsibilities:#Ongoing Quality Assurance:Conducted routine quality checks of both finished products and raw materials, ensuring that they adhered to established specifications and industry standards.Participated in ongoing training focused on GLP, GMP, and regulatory protocols to remain up-to-date with current industry standards and improve testing methodologies.#Microorganism Identification:Performed detailed API testing for the identification of pathogenic microorganisms and maintained meticulous records to support regulatory documentation and product safety assurance.#Regulatory Compliance:Applied knowledge of FDA, TGA, WHO, and other relevant regulatory frameworks to ensure that all manufacturing processes met international compliance standards.Contributed to regulatory documentation and audit preparations, ensuring the company’s adherence to global quality control requirements.

Dhaka, Bangladesh

Key Responsibilities:#Microbial Quality Control:Performed sterility testing and endotoxin testing for small molecules and infusion drugs to ensure the absence of microbial contamination.Conducted bioburden testing to measure microbial content prior to sterilization and maintained environmental monitoring programs (air, water, surfaces) to ensure compliance with regulatory standards.#In-Process Control:Monitored and verified critical parameters like temperature, pressure, and pH during drug manufacturing to ensure consistency and quality.Performed real-time sampling and testing on in-process materials, ensuring they met required specifications.Maintained accurate documentation for GMP compliance and regulatory audits.#Regulatory Compliance:Applied FDA, TGA, WHO, and GLP regulatory guidelines in quality control processes, ensuring all products and processes met international standards.

Doctor Of Philosophy - Phd, Immunology

Master Of Science - Ms, Microbiology, 3.94 Out Of 4.00 (First Class First)

Bachelor Of Science - Bs, Microbiology, 3.77 Out Of 4.00 (First Class Third)