Innovating molecular diagnostics and therapeutics targeting disease affecting women's health!Engaged in endometriosis research since 2000, focusing on the roles of macrophage stimulating and transforming growth factors in the pathology of endometriosis, and more recently on gap junctions, which was the basis for developing a novel diagnostic assay of endometriosis using single-cell analyses.

Women's health including Cancer Research on endometrial cancer, cervical cancer, and breast cancer; and inflammatory gynecologic disease: endometriosis pathophysiology and diagnostics (patent pending)Obesity pathways and microenvironmental influence in epigenetic reprogramming of endometrial cells to promote oncogenesisSingle-cell characterization: single-cell genomics and mass cytometry (CyTOF)Intersection between cell signaling, cell-cell communication, and epigeneticsOrganized and co-chaired sessions in Multiscale Cancer Systems Biology Symposium in collaboration with Houston Methodist Research InstituteWrote and published article on single cell characterization in Onclive:http://www.onclive.com/publications/obtn/2015/july-2015/the-era-of-interrogating-single-cells-in-cancer-biopsy-is-now/1Examples of recent peer-review publications: Cell Reports 2020Cancers 2020Cancer Research (2016, 2017, 2018, 2019, 2020)Oncogene (2015)Clinical Epigenetics (2015)Cancer Cell (2013)Clinical Cancer Research (2013)For complete list of publications follow link: http://www.ncbi.nlm.nih.gov/pubmed/?term=kirma+n

BASiC specializes in single-cell isolation and characterization, which include the C1 single-cell processing, Biomark microfluidic PCR, scRNA-seq. scATAC-seq, Helios CyTOF, and atomic force microscopy. BASiC also provides core services for biomolecular studies including multiplex assays and pyrosequencing for SNP and DNA methylation analyses. Bioinformatics analysis is available for these platforms. Projects supported by BASiC include basic science, and translational research. Accomplishments:• Integrated innovative single-cell technologies with platforms of a previous facility (Core for Advanced Translational Technologies) to form the Bioanalytics and Single-Cell (BASiC) Core• Introduced and optimized single-cell RNA-seq and expression analysis, using the C1 pipelines.• Oversaw the acquisition and installation of the Helios CyTOF platform to provide single-cell proteomics services; established antibody panels to streamline CyTOF services to users• Developed new standard operating procedures to fit BASiC Core single-cell mission• Integrated iLab online portal services for BASiC Core platform management, service requests, interphase with users and billing • Oversaw the operations of the BASiC Core and managed personnel• Managed BASiC Core finances; planned and implemented core budget• Reported BASiC Core activities, progress, and budget to University Core Research Facilities Committee and Office of Vice President of Research• Consulted with BASiC Core users to help them in project design and implementation• Presented seminars, organized workshops, and developed advertising material to enhance awareness of BASiC Core• Authored an article on the BASiC Core and the advent of single-cell technology in OncLive, an online journal for oncologists• Developed and issued ‘Request for Applications’ to fund single-cell based research pilot projects

The UT Health San Antonio Center for the NCI-funded U54 Cancer Systems Biology Program (CSBP) is a multi-site research endeavor to enhance our understanding of epigenomic and chromatin interactions in cancer drug resistance. Cancer systems biology focuses on using systems biology approaches, including computational and mathematical modeling, to study cancer as a complex biological system at multiple scalesThe goals of the UT Health San Antonio CSB Outreach Program are:-Develop a new generation of scientists who appreciate and perform cancer systems biology research-Enhance scientific interactions and collaborations through annual Symposia and communication with other CSB Centers and institutions involved in cancer research and systems biology.-Provide an online presence to share databases, computational tools, and information on cancer systems biology

Cancer Research, gynecologic cancers; Benign gynecologic disorders, endometriosis. Cell signaling; inflammation; hormonal regulation, metastasis, molecular and cell biology. Nutrition aspects of breast cancer, including phytoestrogens and environmenal factors. Publications list is available at pubmed.org. (key word search: Kirma N.)Recently:Initiated and published research project on local invasion and lymph node involvement of oral cancer, a major public health issue in South Texas. Research focused on molecular and epigenetic aspects of oral cancer in an effort to develop novel prognostic markers and personalized therapeutic strategies.Supervised project on endometrial cancer recurrence and metastasis. Discovered new pathways relevant to endometrial cancer progression involving epigenetic modification and epithelial-mesechymal transition mechanisms.Experience in grant and scientific manuscript writing. Great writing and oral communication skills.Involved in mentoring and supervising postdoctoral fellows, OB/GYN residents and medical students in scientific research. Taught classes in biochemsitry, hormonal carcinogenesis, uterine cancer and gynecologic cancer epigenetics.Conducted research on the benefits of T'ai Chi Ch'uan in the elderly as part of community service learning project involving master of public health students.

This is a collaborative effort to bring an eclectic range of martial arts, fitness and wellness activities under one roof in San Antonio, Texas - including T’ai Chi Ch’uan (Taijiquan), Shaolin Kung Fu, Capoeira (an Afro-Brazilian martial arts), Chi Kung (qigong), meditation, yoga, therapeutic massage, and more. We believe improving health involves a complementary mix of physical, mental and wellness activities. In addition to introducing different martial arts, self-defense, and wellness activities to San Antonio, we also hope to provide a space to enhance intercultural understanding through learning about the these arts, their countries of origin, culture and language (for example, Mandarin classes coming soon). We hope to bring these activities through ongoing classes and workshops to the San Antonio and neighboring communities! Stay tuned as we add and update our classes and announcements for workshops!www.martialartswellnessgroup.com

Bringing the benefits of Tai Chi Chuan to San Antonio! We offer high quality T'ai Chi Ch'uan and Chi Kung instruction for health, internal balance and self defense. Over 15 years teaching experience and 19 years of practice.As the mentor on a mini-grant from the Center of Medical Humanities and Ethics, University of Texas Health Science Center (UTHSCSA), I and MPH students under my supervision performed research on the benefits of T'ai Chi Ch'uan on mobility. This research received an outstanding research project award at the Annual Community Service Learning Conference, UTHSCSA (2010).In addition to ongoing classes, I have provided instruction and demonstrations at:Women Heart Support Group, Methodist Stone Oaks Hospital (San Antonio, TX)SaludAmerica Summit (Prevent Obesity among Latino Children, San Antonio, TX)World Tai Chi Day (San Antonio, TX)San Antonio libraries and high schoolsYMCAUniversity of Texas Health Science Center @ San AntonioPrivate organizations and businessesAtlanta botanical gardensSuper Show (Atlanta, GA)

Biomedical research on estrogen and cell signaling pathways in breast and cervical cancers.