Nathan Bandow Email & Phone Number

San Francisco, CA, US

Leverkusen, North Rhine-Westphalia, DE

South San Francisco, California, US

• Developed closed manufacturing scale Allogeneic CAR-T cell therapy process using automated cellprocessing equipment, working with vendors to evaluate new and existing technologies (Sefia, Sepax,LOVO, Ekko, Prodigy.
• Oversaw process team production of CAR-T cells using transduction (LVV) and transfection(electroporation: MaxCyte, BTX, Nucleofector) to generate allogeneic CAR-T cells in bioreactor tomaximize therapeutic yield.
• Identified Drug Product manufacturing materials & staffing inefficiencies, enabling an 80%reduction in production run costs.
• Spearheaded a new testing platform for manufacturing, utilizing emerging technologies toreduce development run costs by 98% per run.
• Tech-Transferred development processes to CMO & internal manufacturing sites with batch recordgeneration/review, leading to the manufacture & clinical availability of treatments.
• Worked with Quality Assurance and External Manufacturing-SC to address/resolve deviations, nonconformance issues and raw material supply during clinical manufacturing processes.

Paris, France, FR

• Led a new platform development project, increasing monoclonal antibody production by 250%& process robustness by 300%.
• Developed strategy for $1.5M+ CAPEX purchase through vendor prototyping collaboration,reducing FTE & materials costs while increasing development throughput capabilities by 400%.
• Created proof of concept process to link manufacturing unit operations resulting in thetransition from two manufacturing steps into a single step.
• Scale up and scale down of perfusion based mammalian cell culture (CHO) for monoclonal antibody production from shake flasks to various scales of bioreactors including the use of single use (SUB) ambr® and WAVE.
• Monitoring of metabolites and growth conditions (ViCell, Cedex Bio HT, RAPIDlab, osmometer, etc)

Ames, Iowa, US

• Investigated a new treatment for Wilson’s Disease through translational medicine collaboration with the Helmholtz Center Munich in Germany
• Created production process that increased output by 200%, meeting drug substance supplygoals for pre-clinical animal studies.
• Solved critical study problem by creating a modified western blot immunoassay to test antibodies purified from rat serum using Protein G (affinity chromatography), due to its better binding of rat IgG than Protein A.
• Preparative large-scale purification of extracellular proteins and secondary metabolites from fermentation broth for further study and use in human and animal medicine.
• Scale up culture growth from agar plates to shake flasks to various sizes of bioreactors using controlled atmospheres.
• Executed critical first stage of project for 4.5-million-dollar grant from Advanced Research Projects Agency-Energy (ARPA-E) funded program focused on conversion of natural gas to natural products for use in biofuels

Ames, Iowa, US

• Mentored 210 students to improve critical reasoning skills, by creating engaging andinformative lesson plans.
• Advocated for young people in underserved urban schools to gain an interest in Science,Technology, Engineering and Mathematics (STEM) fields through regular in class interactionwith science professionals.

Ames, Iowa, US

• Regularly used several forms of spectroscopy (UV-Vis, Fluorescence, circular dichroism CD, atomic absorption AA) to monitor protein stability, structure, binding and aggregation.
• Characterized a modified peptide methanobactin (mb) with one of the highest known binding constants, as high as 4.06 x 10^43 M-1, using isothermal titration calorimetry (ITC) Due to the limitations of the ITC and.

Ames, Iowa, US

Taught BBMB 411 both the Fall '09 and Fall '10. BBMB 411 is a capstone course in biochemical laboratory techniques covering the areas of DNA, lipids, carbohydrates, kinetics, as well as protein purification and expression using various techniques ranging from; RFLP, PCR, RT-PCR, cloning, UV-Vis spectroscopy, to various types of chromatography such as, Gas.

Master Of Business Administration - Mba

Ph.D, Biochemistry

B.S., Biochemistry