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Cell therapy product development leader withdemonstrated success in leading multifunctional departments and spearheading matrixedproject teams across the entire product lifecycle from early-stage clinicaldevelopment and into registration-enabling filings. Currently accountable for all aspects ofAllogeneic Cell Therapy Technical Development & Operations, including establishingmultigenerational strategy, technical team leadership & engineered T cell productdevelopment, mentorship & employee engagement, executive communication, and earlyCMC-enabling strategy.Assume good intent. Always say "please" and "thank you". Show up and do epic s***.
Tune Therapeutics
View- Website:
- tunetx.com
- Employees:
- 80
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Vice President, Portfolio Strategy And OperationsTune TherapeuticsKirkland, Wa, Us
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Tune TherapeuticsKirkland, Wa, Us
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Sr. DirectorTune Therapeutics Jan 2022 - PresentDurham, North Carolina, Us
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Director, Allogeneic Cell Therapy Platform LeaderBristol Myers Squibb Jan 2020 - Jan 2021Lawrence Township, Nj, UsFounder and platform architect for Allogeneic Cell Therapy Technical Development group; accountable for technology design, project strategy, and experimental execution of Allo platform products, while serving as the business partner for research, clinical, portfolio strategy and commercial teams. Director-level leader for engineering integration teams, and matrix leaders across multidisciplinary cell therapy CMC functions (analytical development, quality, regulatory, operations, MSAT, etc.) for early assets. Responsible for overall technical and strategic success of the platform, from technology identification/funneling to regulatory filings in order to address unmet medical needs. -
Associate Director, Allogeneic Cell Thearapy Cmc Product StrategyCelgene Aug 2019 - Jan 2021Summit, New Jersey, UsFounder & product development strategy leader for novel Allogeneic Platform Team. Leveraged portfolio learnings across autologous CAR-T products to derive a production-scale platform for gene-edited T cell therapies - from concept, to technology identification, and end-to-end proof of concept in an accelerated manner. Accessed available resources and adapted a startup mentality to secure budget, apply a rapid-iteration innovation loop, and build a new team of engineers and Ph.D. level scientists. Delivered project collateral (white papers, invention disclosures, technology intelligence reports) that resulted in accelerated sponsorship and enhanced prioritization in the midst of corporate merger dynamics. -
Associate Director, Analytical Development - Immunoassays LeaderJuno Therapeutics, Inc. Apr 2018 - Aug 2019Seattle, Wa, UsDirector-level leader of 18 staff across flow cytometry and cell-based assay analytical development teams, consisting of team leaders, Ph.D. Scientists, and project leaders across 6 clinical stage CAR-T products. Successfully delivered functional deliverables across method development, qualification, transfer, and assay lifecycle strategy for internal and external customers. Authored content for BLA and ex-US regulatory filings for Breyanzi, and CMC Analytical Strategy leader for clinical stage orva-cel program. Also served as facilitator for top-end Technical Development governance team, while actively coaching project teams and bridging communication between programs, corporate governance and senior leaders. -
Sr. Scientist, T Cell Product CharacterizationJuno Therapeutics, Inc. Apr 2016 - Apr 2018Seattle, Wa, UsCo-founded T cell Product Characterization department, and served as Breyanzi analytical product characterization leader. Responsible for MoA, justification of CQAs (critical quality attributes), CMC correlative analysis, and extended characterization strategy & testing logistics. Chaired the CMC correlative analysis team and served as division representative for Neurotoxicity Working Group.
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Scientist, Analytical Development & Head Of Assay SupportJuno Therapeutics, Inc. Mar 2015 - Apr 2016Seattle, Wa, UsFounded the Assay Support Group, an operations-focused organization responsible for executing analytics for IND-enabling process development. Built new lab, established KPIs, and developed data reporting infrastructure to execute work in support of clinical stage development. Proactively led matrixed assay teams across Analytical Development and Quality Control to optimize assays and increase performance while reducing data turnaround time, with oversight across multiple assays platforms and technologies (ligand-binding assays, flow cytometry, cell based and potency assays, etc.)
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Flow Cytometry Scientist, Process And Analytical DevelopmentJuno Therapeutics, Inc. Apr 2014 - Mar 2015Seattle, Wa, Us
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Senior Scientist & Flow Cytometry Core Lab SupervisorSnbl Usa Oct 2012 - Apr 2014Kagoshima, Kagoshima, Jp- Architect of GLP-compliant flow cytometry core lab services. Designed SOPs and established best practices to efficiently develop and validate functional and phenotyping assays for regulated pre-clinical studies.- Responsible for all aspects of immunotoxicology evaluation, including study design, data analysis/reporting, benchwork, consultation with Sponsors and Study Directors, and mentorship of analytical scientists and technicians. Tasked with long-term strategic planning and operations of immunology services.- Developed cell-based assays to mechanistically interrogate off-target effects, including drug-induced thrombocytopenia. Led multi-departmental effort to correlate developmental, phenotypic and functional endpoints of primary hemostasis for multiple programs.- Extensive experience in multiparameter flow cytometry profiling of all leukocyte populations, with an emphasis on T, B and myeloid cell activation. Adept at interrogating complex and rare populations in NHPs, including CD34+ stem cells and myeloid progenitors in active bone marrow.- Scientific consultant for diverse therapeutic programs with a specific emphasis on regulatory strategy and study design for immunology-related disease models and test articles.- Manager and scientific lead for analytical scientists, technicians and administrative coordinators. Responsible for establishing scientific rationale, planning logistics, scheduling and directing project teams to create assays that comply with FDA/EMA Bioanalytical guidances and FDA/ICH Immunotoxicology guidances.- Author of immunotoxicology articles and posters. Company-selected speaker for a major industry conference.- Awarded SNBL USA 2013 Employee of the Year. -
Post Doctoral FellowBenaroya Research Institute Jun 2012 - Oct 2012Seattle, Wa, Us -
Doctoral FellowUniversity Of Washington Sep 2005 - Jun 2012Seattle, Wa, Us -
Research ScientistUniversity Of Washington 2004 - 2005Seattle, Wa, Us
Nathan Yee Skills
Nathan Yee Education Details
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University Of Washington - School Of MedicineImmunology -
University Of WashingtonMicrobiology
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University Of WashingtonBiochemistry
Frequently Asked Questions about Nathan Yee
What company does Nathan Yee work for?
Nathan Yee works for Tune Therapeutics
What is Nathan Yee's role at the current company?
Nathan Yee's current role is Vice President, Portfolio Strategy and Operations.
What is Nathan Yee's email address?
Nathan Yee's email address is na****@****ics.com
What is Nathan Yee's direct phone number?
Nathan Yee's direct phone number is +120658*****
What schools did Nathan Yee attend?
Nathan Yee attended University Of Washington - School Of Medicine, University Of Washington, University Of Washington.
What skills is Nathan Yee known for?
Nathan Yee has skills like Flow Cytometry, Immunology, Car T Cells, Cancer Immunotherapy, Cell Biology, Qpcr, Pharmaceutical Process Development, Animal Models, Assay Development, Analytical Methods Development, Cell, Immunoassays.
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